A theoretical and experimental study of phosphate ester inhibitors for AISI 1018 in carbon dioxide-saturated 3.5 wt% NaCl solution

Phosphate ester was investigated as a corrosion inhibitor for AISI 1018 carbon steel in carbon dioxide-saturated chloride solutions at different temperatures and pressures. The corrosion tests were realized by electrochemical techniques, weight loss measurements, bubble tests, and a high-pressure/high-temperature autoclave system. The corrosion tests demonstrated that the investigated molecule is an excellent corrosion inhibitor. The inhibiting effect is even bigger at high pressure and temperature than at atmospheric pressure and room temperature. The thermodynamic parameters were calculated and determined to obey the Langmuir isotherm. Polarization studies revealed that the evaluated inhibitor is a mixed type.     

Securing light clients in blockchain with DLCP

In blockchain, full nodes (FNs) are peers that store and verify entire chains of transactions. In contrast, light clients (LCs) are those with limited resources, and for this reason, they request only block headers from FNs for transaction verification—using protocols like Simple Payment Verification (SPV). In an approach to prevent FN tampering on transaction verification (byzantine fault), LCs request block headers from multiple FNs and compare received responses. One problem with this approach is that an LC must connect to each FN and perform the same cryptographic operations with each one repeatedly, which leads to client‐side complexity and slower response. We propose an alternate approach to tackle this issue, in which LCs can encrypt a request for block headers only once, and send that request to a predetermined set of FNs to access, process, and reply back in a single response. Our approach, called Distributed Lightweight Client Protocol (DLCP), enables LCs to verify with little effort if FNs have agreed on a response. From an experimental evaluation, we observed that DLCP provided lower latency and reduced computing and communication overhead in comparison with the existing conventional approach.     

Corrosion and mechanical properties of plasma electrolytic oxidation‐coated AZ80 magnesium alloy

Plasma electrolytic oxidation (PEO) coatings were produced on AZ80 magnesium alloy in a solution containing silicates and phosphates and working at high current densities with short treatment times. The effect of a sealing treatment in boiling water on corrosion and mechanical properties of the coatings were investigated. Moreover, the corrosion mechanism of the samples with and without the sealing treatment was evaluated. The microstructure of the coatings was characterized with scanning electron microscope observation and X‐ray diffraction analysis. The mechanical properties were evaluated with nanoindentation tests and the corrosion resistance was studied by potentiodynamic polarization, electrochemical impedance spectroscopy, and scanning vibrating electrode technique. The results showed that the sealing did not influence the microstructure and the mechanical properties of the samples and instead produced a remarkable increase in the corrosion resistance. The crevice corrosion, present in the sample without the sealing, was avoided with the treatment in boiling water.     

A platform for P2P agent-based collaborative applications

The operational environment can be a valuable source of information about the behavior of software applications and their usage context. Although a single instance of an application has limited evidence of the range of the possible behaviors and situations that might be experienced in the field, the collective knowledge composed by the evidence gathered by the many instances of a same application running in several diverse user environments (eg, a browser) might be an invaluable source of information. This information can be exploited by applications able to autonomously analyze how they behave in the field and adjust their behavior accordingly. Augmenting applications with the capability to collaborate and directly share information about their behavior is challenging because it requires the definition of a fully decentralized and dependable networked infrastructure whose nodes are the user machines. The nodes of the infrastructure must be collaborative, to share information, and autonomous, to exploit the available information to change their behavior, for instance, to better accommodate the needs of the users to prevent known problems. This paper describes the initial results that we obtained with the design and the development of an infrastructure that can enable the execution of collaborative scenarios in a fully decentralized way. Our idea is to combine the agent-based paradigm, which is well suited to design collaborative and autonomous nodes, and the peer-to-peer paradigm, which is well suited to design distributed and dynamic network infrastructures. To demonstrate our idea, we augmented the popular JADE agent-based platform with a software layer that supports both the creation of a fully decentralized peer-to-peer network of JADE platforms and the execution of services within that network, thus enabling JADE multiagent systems (MASs) to behave as peer-to-peer networks. The resulting platform can be used to study the design of collaborative applications running in the field.     

Consistency,availability, and partition tolerance in blockchain: a survey on the consensus mechanism over peer-to-peer networking

Annals of Telecommunications - Blockchain is a disruptive technology that relies on the distributed nature of the peer-to-peer network while performing an agreement, or consensus, a mechanism to...     

Preface to the Special Issue on “Heterogeneous Photocatalysts: From Fundamentals to Innovative Applications”

Topics in Catalysis -     

Development of low-alcohol isotonic beer by interrupted fermentation

Alcohol-free beer with isotonic properties is getting more popular and its production can be carried out by different production strategies; however, interrupted fermentation is still a challenge. Therefore, the objective of this study was to develop a low-alcohol isotonic beer (<0.5% v/v) by interrupted fermentation. Moreover, the major objective is to compare the developed product to commercial beverages (sports drinks, ‘Pilsen' regular beer, alcohol-free beers and low-alcohol isotonic beer). The beverages were evaluated based on pH, alcohol content (% v/v), total titratable acidity (mEq L⁻¹), osmolality (mOsmol kg⁻¹), bitterness International Bitterness Units, colour European Brewery Convention, total phenolic compounds (mg L⁻¹ gallic acid), reducing and total sugars (%) and Na and K contents (mg L⁻¹). The developed low-alcohol isotonic beer presented characteristics similar to sports drinks, with the advantage of being richer in phenolic compounds and suitable osmolality. Despite salts were added in its formulation, the grades attributed to all beers employed in the sensory evaluation, as well as the purchase intention did not present significant differences.     

Discovery of Affinity-Based Probes for Btk Occupancy Assays

Bruton's tyrosine kinase (Btk) is an attractive target for the treatment of a wide array of B-cell malignancies and autoimmune diseases. Small-molecule covalent irreversible Btk inhibitors targeting Cys481 have been developed for the treatment of such diseases. In clinical trials, probe molecules are required in occupancy studies to measure the level of engagement of the protein by these covalent irreversible inhibitors. The result of this pharmacodynamic (PD) activity provides guidance for appropriate dosage selection to optimize inhibition of the drug target and correlation of target inhibition with disease treatment efficacy. This information is crucial for successful evaluation of drug candidates in clinical trials. Based on the pyridine carboxamide scaffold of a novel solvent-accessible pocket (SAP) series of covalent irreversible Btk inhibitors, we successfully developed a potent and selective affinity-based biotinylated probe 12 (2-[(4-{4-[5-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)pentanoyl]piperazine-1-carbonyl}phenyl)amino]-6-[1-(prop-2-enoyl)piperidin-4-yl]pyridine-3-carboxamide). Compound 12 has been used in Btk occupancy assays for preclinical studies to determine the therapeutic efficacy of Btk inhibition in two mouse lupus models driven by TLR7 activation and type I interferon.     

Has a non‐native cichlid of the genus Amatitlania (Actinopterygii,Cichlidae) adapted to the headwaters in Brazilian semi‐arid?

Several fish species from Central America and other regions have been introduced into Brazil. In this study, we evaluated the bioecological aspects of a non‐native cichlid of the genus Amatitlania (convict cichlid) and its possible establishment in high‐altitude forest enclaves of semi‐arid Northeastern Brazil. Specimens of Amatitlania nigrofasciata (Günther, 1867) were captured in a local stream displaying abiotic conditions like those of its natural range of distribution. The individuals collected were predominantly adult, insectivorous and displayed normal length–weight relationships, although we observed some phenotypical plasticity (variation in body depth, and a morphologically abnormal dorsal fin in three cases). Our results indicate that A. nigrofasciata has successfully colonized an Atlantic forest enclave in the Brazilian semi‐arid region, making it necessary to adopt measures to prevent the species from spreading to other water bodies in the surroundings.