Endoglin Targeting: Lessons Learned and Questions That Remain

Approximately 30 years ago, endoglin was identified as a transforming growth factor (TGF)-β coreceptor with a crucial role in developmental biology and tumor angiogenesis. Its selectively high expression on tumor vessels and its correlation with poor survival in cancer patients led to the exploration of endoglin as a therapeutic target for cancer. The endoglin neutralizing antibody TRC105 (Carotuximab^®, Tracon Pharmaceuticals (San Diego, CA, USA) was subsequently tested in a wide variety of preclinical cancer models before being tested in phase I-III clinical studies in cancer patients as both a monotherapy and in combination with other chemotherapeutic and anti-angiogenic therapies. The combined data of these studies have revealed new insights into the role of endoglin in angiogenesis and its expression and functional role on other cells in the tumor microenvironment. In this review, we will summarize the preclinical work, clinical trials and biomarker studies of TRC105 and explore what these studies have enabled us to learn and what questions remain unanswered.     

Real-time 3D thermal modeling of a magnetically levitated planar actuator

A transient thermal model used to monitor the temperature distribution in real-time in a long-stroke moving-magnet planar actuator is presented. The temperature distribution in the stator coils of the planar actuator depends on the trajectory of the levitated magnet plate as the set of active coils changes with the position of the translator. Using the presented real-time model, the transient thermal behavior can be investigated. Using this thermal model, the commutation algorithm of the planar actuator is adjusted to actively limit the temperature of the coils, and better spread the temperature over the stator coils.     

The deformation of the moving magnet plate of a commutated magnetically levitated planar actuator

This paper presents a method to calculate the deformation of the magnet plate of a commutated magnetically levitated planar actuator using a linked electromagnetic–mechanical model. The force and torque distribution on the moving magnet array is obtained from an electromagnetic model based on the surface charge method and the Lorentz force and torque integral. The mechanical model is a state-space model derived from FEM. This mechanical model uses the force and torque distribution to determine the deformation of the magnet plate during movement due to the commutated coil set.     

Electrical and photoluminescence properties of evaporated CuIn1−xGaxTe2 thin films

Polycrystalline thin films of CuIn_1−xGa_xTe₂ have been deposited by flash evaporation on Corning glass 7059 substrates at T_s=200°C. Hall and resistivity measurements have been carried out down to 77 K. These films are p-type and the variation of the resistivity may be linked to defects, disorder of the material or grain boundaries. The PL spectra of these films after annealing in argon atmosphere at T_a=450°C have showed a broad band emission between 0.98 and 1.12 eV in which the main peak appears at 1.05 eV (at 4.2 K).     

Treating phobic children: Effects of EMDR versus exposure.

This study examined the efficacy of eye movement desensitization and reprocessing (EMDR) and exposure in the treatment of a specific phobia. Twenty-six spider phobic children were treated during 2 treatment phases. During the first phase, which lasted 2.5 hr, children were randomly assigned to either (a) an EMDR group (n?=?9), (b) an exposure in vivo group (n?=?9), or (c) a computerized exposure (control) group (n?=?8). During the 2nd phase, all groups received a 1.5-hr session of exposure in vivo. Therapy outcome measures (i.e., self-reported fear and behavioral avoidance) were obtained before treatment, after Treatment Phase 1, and after Treatment Phase 2. Results showed that the 2.5-hr exposure in vivo session produced significant improvement on all outcome measures. In contrast, EMDR yielded a significant improvement on only self-reported spider fear. Computerized exposure produced nonsignificant improvement. Furthermore, no evidence was found to suggest that EMDR potentiates the efficacy of a subsequent exposure in vivo treatment. Exposure in vivo remains the treatment of choice for childhood spider phobia. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

New energy retrofit concept: ‘renovation trains’ for mass housing

A large operation is required to make Europe's existing housing stock more energy efficient, in terms of both demand reduction as well as the installation of local renewable energy technologies. The combination of overall (national) energy targets and the European Union's Energy Performance of Buildings Directive (EPBD) targets suggests the scale of this task involves the retrofitting of millions of houses. An example of a large-scale, rapid process is presented where a series of houses have been retrofitted using a standardized process. A pilot project exploring this strategy has been completed in Kerkrade, the Netherlands. Several innovations were introduced, tested and refined for the renovation of 150 houses: a serial retrofit process, a renovation time of ten days per house with the houses inhabited during the process, and responsibility for energy performance assigned to the construction team. The construction process is a ‘renovation train’ moving from one house to the next. The experiences are now being used and developed for a follow-up project: a new concept can be used to scale up the process from 100 to 10 000 renovations a year.     

One laminated bamboo-frame house per hectare per year

This paper presents an outline of a quantitative analysis that demonstrates the global potential of bamboo as a “modern” construction material. The underlying goal is to contribute to a real shift in resource management by focussing on renewable resources in general and on the high brow, modern use of bamboo as an alternative for construction products such as concrete, brick and (hard)wood in particular. The analysis illustrates how laminated bamboo-frame building could be a direct alternative for wood-frame building, bamboo having a great advantage in yearly yield per forest area compared to wood. Current and potential bamboo resources in Colombia are posed against required material volumes for constructing a model house, resulting in a practical and realistic view on bamboo’s global potential on lowering the environmental impact of the built environment.     

Dimensional and componential structure of a hierarchical organization of pain-related anxiety constructs.

Research has identified several anxiety and fear constructs that contribute directly or indirectly to the chronic course of pain. One way to gain insight into the frequently observed interrelations between these constructs may be by conceptualizing them within a hierarchical structure. In this structure, general and specific constructs are proposed at different levels of a hierarchical tree. The present study sought to find evidence for this idea by exploring the dimensional and componential structure of a hierarchical representation of pain-related anxiety constructs. Small cards describing the individual items of 9 pain-related anxiety measures were presented to undergraduate students (N = 294), who were asked to sort them into piles of what they perceived as items of similar meaning. Cluster analysis (additive tree analyses) revealed cluster groups that could be interpreted along the lines of the proposed hierarchical structure. Multidimensional scaling analysis showed that the similarity data are characterized by a dimension that runs from general affective to pain-specific concerns. This study thus offers empirical support for the postulation of a general and specific hierarchical ordering of these constructs. Furthermore, its results endorse the independent use of various pain-related anxiety measures in research and practice aiming to assess negative emotional constructs that contribute to pain. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Mobile satellite reception with a virtual satellite dish based on a reconfigurable multi-processor architecture

Traditionally, mechanically steered dishes or analog phased array beamforming systems have been used for radio frequency receivers, where strong directivity and high performance were much more important than low-cost requirements. Real-time controlled digital phased array beamforming could not be realized due to the high computational requirements and the implementation costs. Today, digital hardware has become powerful enough to perform the massive number of operations required for real-time digital beamforming. With the continuously decreasing price per transistor, high performance signal processing has become available by using multi-processor architectures. More and more applications are using beamforming to improve the spatial utilization of communication channels, resulting in many dedicated digital architectures for specific applications. By using a reconfigurable architecture, a single hardware platform can be used for different applications with different processing needs.In this article, we show how a reconfigurable multi-processor system-on-chip based architecture can be used for phased array processing, including an advanced tracking mechanism to continuously receive signals with a mobile satellite receiver. An adaptive beamformer for DVB-S satellite reception is presented that uses an Extended Constant Modulus Algorithm to track satellites. The receiver consists of 8 antennas and is mapped on three reconfigurable Montium TP processors. With a scenario based on a phased array antenna mounted on the roof of a car, we show that the adaptive steering algorithm is robust in dynamic scenarios and correctly demodulates the received signal.