From Stem Cells to Bone-Forming Cells

Bone formation starts near the end of the embryonic stage of development and continues throughout life during bone modeling and growth, remodeling, and when needed, regeneration. Bone-forming cells, traditionally termed osteoblasts, produce, assemble, and control the mineralization of the type I collagen-enriched bone matrix while participating in the regulation of other cell processes, such as osteoclastogenesis, and metabolic activities, such as phosphate homeostasis. Osteoblasts are generated by different cohorts of skeletal stem cells that arise from different embryonic specifications, which operate in the pre-natal and/or adult skeleton under the control of multiple regulators. In this review, we briefly define the cellular identity and function of osteoblasts and discuss the main populations of osteoprogenitor cells identified to date. We also provide examples of long-known and recently recognized regulatory pathways and mechanisms involved in the specification of the osteogenic lineage, as assessed by studies on mice models and human genetic skeletal diseases.     

Tape casting of polysiloxane-derived ceramic with controlled porosity and surface properties

Tape casting has been applied to produce porous hybrid and SiOC ceramic tapes using ceramic precursors and commercially available polysiloxanes as polymeric binders. SiC particles of two different mean sizes (4.5 or 6.5?μm) were used as inert fillers to prevent shrinkage and increase mechanical stability. Macroporosity was adjusted by varying the azodicarbonamide (ADA) content from 0 to 30?wt.%. Decomposition of the polysiloxanes at 600?°C resulted in the generation of micropores with high specific surface area (187–267 m²?g^?1) and a predominant hydrophobic behavior. At 1000?°C mainly meso/macroporosity were observed (SSA: 32–162 m²?g^?1) accompanied by increased hydrophilicity. The influence of ADA content, SiC size, and pyrolysis temperature on open porosity (2.5–37%), average pore size (<0.01–1.76?μm), surface characteristics, and flexural strength (10.5–121?MPa) were investigated. The porous tapes with different surface characteristics and controlled structure are highly promising for applications involving membrane processes, particularly microfiltration systems (0.1–10?μm).     

Facile preparation of glycine-based mesoporous graphitic carbons with embedded cobalt nanoparticles

Journal of Materials Science - A simple route has been developed for the preparation of mesoporous graphitic carbons with embedded cobalt nanoparticles just using glycine as a nitrogen source,...     

材料的重要性

《材料的重要性》是《景观设计理论》的一段节选。《景观设计理论》旨在不使用专业术语或其他领域假说的前提下,结合景观设计过程向学生介绍内在理论思想。《材料的重要性》是本书的五章之一。每一章针对特定理论,解释了其基础和来源,探讨了它对设计的重要性,列举了20—21世纪与其相关的设计案例,整理了该理论的辩论(尤其是有关现代和后现代思想),最后还有相关阅读材料清单和需要学生们思考的问题。本文分为如下3个部分：第一部分,物质性,介绍“辩证唯物主义”“媒介即信息”“物质实践”和“编码”等理论及其在设计中的运用;第二部分,通过“建构表达”“地貌代理人策略”“石材的面层”“材料的暗示”“人造,但不是伪造”等理论,介绍材料的真实性及其在设计中的运用;第三部分,复写理论及应用,包括“剩余物”“复写的展示性”“未来的复写”和“虚构的复写”等内容。     

风景园林与绿色基础设施在城市流域水资源规划中的重要作用

通过绿色基础设施途径,处理美国波士顿北部的马萨诸塞州城市流域的水资源规划问题。从多个尺度为风景园林师提供水资源规划的经验与启发,探究公众对新型绿色基础设施解决方案的态度与偏好,以及公众偏好对于整体规划设计的重要作用。     

A qualitative exploration of arts-based neighbourhood revitalization: The case of ‘The Space at 2106 Main’ in West Tampa,Florida

As cities are compelled to compete for new sources of investment and revenue, arts-based economic development strategies have become the norm. The purpose of this paper is to revisit and reevaluate some of the conventional claims about the arts as an important economic development strategy by exploring a case study called “The Space at 2106 Main” in a rapidly gentrifying neighbourhood called West Tampa. The results of this study suggest that the arts are indeed assuming a greater role in economic policy under the auspices of West Tampa community redevelopment areas (CRA) and the direct actions of various arts related entrepreneurs. The results however, point to a mixed picture that raises difficult questions about the medium to long-term effects of this urban redevelopment strategy, especially on the poor and mostly minority residents of West Tampa.     

An approach to technical risk assessment

This paper describes a framework for assessment of the risk that a proposed machine or system, such as an aircraft or computer, will not operate to its required performance specifications when it is developed. The method is based upon decomposition of the system under assessment into a hierarchy of functionally or structurally defined assessment areas. Within each area, technical risks, and methods of assessing these risks, are identified. The framework provides a systematic structure for selecting assessment methods and integrating results of the use of selected methods into a coherent overall assessment of the system.     

Performance of the Burwarton Estate Waste Stabilization Ponds

The Burwarton Estate waste stabilization ponds, near Bridgnorth, Shropshire, serve a population of 150. There are three ponds in series: a facultative pond, and two equal maturation ponds, followed by two parallel and alternately used constructed wetland ditches. This paper describes the design of the ponds and reports upon their performance during the first two years of operation.     

Achievable working range for solid all-desiccant air-conditioning systems under specific space comfort requirements

Solid desiccant air-conditioning systems present a promising solution, in terms of performance level and environmental protection, pointing out their potential to be coupled with thermal solar or waste heat energy source. Nevertheless, these systems are characterized by constraints to the load they can satisfy, through the trade-off between the dehumidification cooling capacity and the latent load of the conditioned space. On that level, one has to note that, for steady environmental conditions, the conditioned space does not present unique value of load, but range of load, corresponding to an array of acceptable temperature and (usually relative) humidity values. In this work a methodology is proposed for the definition of the system's achievable working range under specific set of space (comfort) requirements. Through this approach, the systems present greater potential for covering the space requirements, thus presenting more possibilities on a design basis, and more flexible control strategies, as well. The proposed methodology is presented and discussed through the case study of a solar desiccant air-conditioning system coupled to a typical residential building.