Active cooling and low carbon comfort

Within the debate about fostering more sustainable built environments one of the key battlegrounds surrounds thermal comfort, and in particular the use of air conditioning. In the search for less energy-intensive alternatives, a renewed interest has emerged around the design vocabulary of ‘passive cooling’. The paper argues that the terminology of passive/active needs inverting for such approaches to gain wider support as a viable alternative to mechanical cooling.

It is argued that non-air-conditioned buildings actively engage with their environments and that the current notion of passive cooling leaves us blind to the ways occupants, buildings and the material culture of interior spaces are all entangled in relations that enable thermal comfort to be actively achieved and maintained. To present this argument for re-categorising low-carbon architecture design as active cooling, the paper draws on the concept of entanglement.     

接地故障中和器全补偿技术及应用

目前世界上普遍应用的配电系统消弧线圈接地方式在一定程度上保证了系统的供电可靠性,但仍然存在接地残流较大和高阻型故障检测难等问题。GFN(接地故障全中和器)具有消除接地电流、准确定位故障点,以及提升供电稳定性和可靠性的作用。介绍了瑞典GFN接地故障全补偿技术的基本原理、功能特点、应用实例和功能扩展等。实用情况表明GFN接地故障全补偿技术可以较为成功地减少特殊瞬时故障。     

Comparison of 10,11‐Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs

Iterative type I polyketide synthases (PKSs) from fungi are multifunctional enzymes that use their active sites repeatedly in a highly ordered sequence to assemble complex natural products. A phytotoxic macrolide with anticancer properties, 10,11‐dehydrocurvularin (DHC), is produced by cooperation of a highly reducing (HR) iterative PKS and a non‐reducing (NR) iterative PKS. We have identified the DHC gene cluster in Alternaria cinerariae, heterologously expressed the active HR PKS (Dhc3) and NR PKS (Dhc5) in yeast, and compared them to corresponding proteins that make DHC in Aspergillus terreus. Phylogenetic analysis and homology modeling of these enzymes identified variable surfaces and conserved motifs that are implicated in product formation.     

Neutrophils Enable Local and Non-Invasive Liposome Delivery to Inflamed Skeletal Muscle and Ischemic Heart

Uncontrolled inflammation is a major pathological factor underlying a range of diseases including autoimmune conditions, cardiovascular disease, and cancer. Improving localized delivery of immunosuppressive drugs to inflamed tissue in a non-invasive manner offers significant promise to reduce severe side effects caused by systemic administration. Here, a neutrophil-mediated delivery system able to transport drug-loaded nanocarriers to inflamed tissue by exploiting the inherent ability of neutrophils to migrate to inflammatory tissue is reported. This hybrid system (neutrophils loaded with liposomes ex vivo) efficiently migrates in vitro following an inflammatory chemokine gradient. Furthermore, the triggered release of loaded liposomes and reuptake by target macrophages is studied. The migratory behavior of liposome-loaded neutrophils is confirmed in vivo by demonstrating the delivery of drug-loaded liposomes to an inflamed skeletal muscle in mice. A single low-dose injection of the hybrid system locally reduces inflammatory cytokine levels. Biodistribution of liposome-loaded neutrophils in a human-disease-relevant myocardial ischemia reperfusion injury mouse model after i.v. injection confirms the ability of injected neutrophils to carry loaded liposomes to inflammation sites. This strategy shows the potential of nanocarrier-loaded neutrophils as a universal platform to deliver anti-inflammatory drugs to promote tissue regeneration in inflammatory diseases.     

Electrodynamics and radiofrequency antenna concepts for human magnetic resonance at 23.5 T (1 GHz) and beyond

Magnetic Resonance Materials in Physics, Biology and Medicine - This work investigates electrodynamic constraints, explores RF antenna concepts and examines the transmission fields (B 1 + ) and RF...     

Psychological constructs in driving automation: a consensus model and critical comment on construct proliferation

As automation in vehicles becomes more prevalent, the call for understanding the behaviour of the driver while driving an automated vehicle becomes more salient. Although a variety of driver behaviour models exist, and various psychological constructs have been said to be influenced by automation, an empirically testable psychological model of automated driving has yet to be developed. Building upon Stanton and Young's model of driving automation, this article presents an updated model of interrelated psychological constructs. The proposed model was created based upon a systematic literature search of driving automation papers and a subsequent quantification of the number of reported links between a selected set of psychological constructs. A secondary aim of this article is to reach consensus in the use of psychological constructs regarding driving automation. Henceforth special attention is paid to resolving the issue of construct proliferation.     

The expansion of Google Scholar versus Web of Science: a longitudinal study

Web of Science (WoS) and Google Scholar (GS) are prominent citation services with distinct indexing mechanisms. Comprehensive knowledge about the growth patterns of these two citation services is lacking. We analyzed the development of citation counts in WoS and GS for two classic articles and 56 articles from diverse research fields, making a distinction between retroactive growth (i.e., the relative difference between citation counts up to mid-2005 measured in mid-2005 and citation counts up to mid-2005 measured in April 2013) and actual growth (i.e., the relative difference between citation counts up to mid-2005 measured in April 2013 and citation counts up to April 2013 measured in April 2013). One of the classic articles was used for a citation-by-citation analysis. Results showed that GS has substantially grown in a retroactive manner (median of 170 % across articles), especially for articles that initially had low citations counts in GS as compared to WoS. Retroactive growth of WoS was small, with a median of 2 % across articles. Actual growth percentages were moderately higher for GS than for WoS (medians of 54 vs. 41 %). The citation-by-citation analysis showed that the percentage of citations being unique in WoS was lower for more recent citations (6.8 % for citations from 1995 and later vs. 41 % for citations from before 1995), whereas the opposite was noted for GS (57 vs. 33 %). It is concluded that, since its inception, GS has shown substantial expansion, and that the majority of recent works indexed in WoS are now also retrievable via GS. A discussion is provided on quantity versus quality of citations, threats for WoS, weaknesses of GS, and implications for literature research and research evaluation.     

Strong converse for the classical capacity of the pure-loss bosonic channel

This paper strengthens the interpretation and understanding of the classical capacity of the pure-loss bosonic channel, first established in [1]. In particular, we first prove that there exists a trade-off between communication rate and error probability if one imposes only a mean photon number constraint on the channel inputs. That is, if we demand that the mean number of photons at the channel input cannot be any larger than some positive number NS, then it is possible to respect this constraint with a code that operates at a rate g(ηNS/(1-p)) where p is the code error probability, η is the channel transmissivity, and g(x) is the entropy of a bosonic thermal state with mean photon number x. Then we prove that a strong converse theorem holds for the classical capacity of this channel (that such a rate-error trade-off cannot occur) if one instead demands for a maximum photon number constraint, in such a way that mostly all of the “shadow” of the average density operator for a given code is required to be on a subspace with photon number no larger than nNS, so that the shadow outside this subspace vanishes as the number n of channel uses becomes large. Finally, we prove that a small modification of the well-known coherent-state coding scheme meets this more demanding constraint.