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排序方式: 共有193条查询结果,搜索用时 46 毫秒
1.
Thibault Colombani Loek J. Eggermont Stephen M. Hatfield Zachary J. Rogers Mahboobeh Rezaeeyazdi Adnan Memic Michail V. Sitkovsky Sidi A. Bencherif 《Advanced functional materials》2021,31(37):2102234
Solid tumors are protected from antitumor immune responses due to their hypoxic microenvironments. Weakening hypoxia-driven immunosuppression by hyperoxic breathing of 60% oxygen has shown to be effective in unleashing antitumor immune cells against solid tumors. However, efficacy of systemic oxygenation is limited against solid tumors outside of lungs and has been associated with unwanted side effects. As a result, it is essential to develop targeted oxygenation alternatives to weaken tumor hypoxia as novel approaches to restore immune responses against cancer. Herein, injectable oxygen-generating cryogels (O2-cryogels) to reverse tumor-induced hypoxia are reported. These macroporous biomaterials are designed to locally deliver oxygen, inhibit the expression of hypoxia-inducible genes in hypoxic melanoma cells, and reduce the accumulation of immunosuppressive extracellular adenosine. The data show that O2-cryogels enhance T cell-mediated secretion of cytotoxic proteins, restoring the killing ability of tumor-specific cytotoxic T lymphocytes, both in vitro and in vivo. In summary, O2-cryogels provide a unique and safe platform to supply oxygen as a coadjuvant in hypoxic tumors and have the potential to improve cancer immunotherapies. 相似文献
2.
Dina V. Dudina Igor S. Batraev Vladimir Yu. Ulianitsky Michail A. Korchagin 《Ceramics International》2014
This article is aimed to discuss the chemical aspects of detonation spraying of powder materials. In this method of coating deposition, ceramic, metallic or composite powders are injected into the barrel of a detonation gun filled with an explosive gaseous mixture. When the latter is ignited, the powders are heated and accelerated toward the substrate. Subjected to high temperatures, the powders are prone to chemical reactions, the reaction products possibly becoming the major phase constituents of the coatings. What types of reactions are possible? Can these reactions be carried out in a controlled manner? We answer these questions considering the interactions of the sprayed powders with the gaseous environment of the barrel as well as those between the phases of a composite feedstock powder. In Computer-Controlled Detonation Spraying (CCDS), the explosive charge and stoichiometry of the fuel-oxygen mixtures are precisely measured and can be flexibly changed. Our studies demonstrate that with the introduction of a highly flexible process of CCDS, detonation spraying has entered a new development stage, at which it can be considered as a powerful method of composition and microstructure tailoring of thermally sprayed coatings. During CCDS of TiO2-containing powders, chemical reduction of titanium dioxide can be carried out to different levels to form either oxygen-deficient TiO2−x or Ti3O5 suboxide. CCDS of Ti3Al can produce titanium oxide coatings when oxidation by the detonation products dominates or titanium nitride-titanium aluminide coatings when oxidation is hindered but the interaction of the powders with nitrogen—a carrier gas component—is favored. During detonation spraying of Ti3SiC2–Cu composites, the Ti3SiC2 phase is preserved only in cold conditions; otherwise, Si de-intercalates from the Ti3SiC2 phase and dissolves in Cu resulting in the formation of the TiCx–Cu(Si) composite coatings. 相似文献
3.
In this paper, area-efficient and high-throughput multi-mode architectures for the SHA-1 and SHA-2 hash families are proposed and implemented in several FPGA technologies. Additionally a systematic flow for designing multi-mode architectures (implementing more than one function) of these families is introduced. Compared to the corresponding architectures that are produced by a commercial synthesis tool, the proposed ones are better in terms of both area (at least 40%) and throughput/area (from 32% up to 175%). Finally, the proposed architectures outperform similar existing ones in terms of throughput and throughput/area, from 4.2× up to 279.4× and from 1.2× up to 5.5×, respectively. 相似文献
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6.
Naghmeh Karimi Michail Maniatakos Chandrasekharan Tirumurti Yiorgos Makris 《Journal of Electronic Testing》2013,29(3):351-366
Modern microprocessors incorporate a variety of architectural features, such as branch prediction and speculative execution, which are not critical to the correctness of their operation yet are essential towards improving performance. Accordingly, while faults in the corresponding hardware may not necessarily affect functional correctness, they may, nevertheless, adversely impact performance. In this paper, we investigate quantitatively the performance impact of such faults using a superscalar, dynamically-scheduled, out-of-order, Alpha-like microprocessor, on which we execute SPEC2000 integer benchmarks. We provide extensive fault simulation-based experimental results that elucidate the various aspects of performance faults and we discuss how this information may guide the inclusion of additional hardware for performance loss recovery and yield enhancement. 相似文献
7.
In this work we address the problem of object tracking in a largely unknown dynamic environment under the additional constraint of real-time operation and limited computational power. The main design directives remain that of real time execution and low price, high availability components. It is in a sense an investigation for the minimum required hardware and algorithmic complexity to accomplish the desired tasks. We present a system that is based on simple techniques such as template matching adapted for use in a dynamically changing environment. After development, the system was evaluated as to its suitability in a traffic monitoring application where it demonstrated adequate performance. 相似文献
8.
The GRAINS thermodynamic and kinetic code for modeling condensation and grain growth in the solar nebula is described. The code calculates CWPI-type (Condensation With Partial Isolation) equilibrium partitioning of 33 chemical elements among 242 gaseous and 520 condensed phases, and growth in the nebula of metal and olivine grains by condensation from the nebular gas accompanied by diffusional redistribution of major and trace elements in those grains. Several examples of the GRAINS application to cosmochemical problems are briefly discussed. 相似文献
9.
Mark M. Goldin Mogely Sh. Khubutiya Vladimir A. Kolesnikov Michail M. Abakumov Anatoly K. Evseev Alexander George Volkov 《Journal of Applied Electrochemistry》2009,39(2):185-189
Anodic oxidation of dilute solutions of sodium sulfate was developed to generate oxidants into aqueous solutions with a diaphragm
electrolyzer, which consisted of titanium anodes covered with mixed oxides of iridium, ruthenium and tin, a titanium cathode,
and Teflon cation-exchange membrane. An electronic device was created for continuous self-purification of cathode surface
from hardness salt deposits. The anodic products of electrolysis were molecular oxygen and sodium persulfate. It should be
noted that sodium persulfate was the only active oxidant. The synthesized anolyte was tested for its oxidizing activity towards
certain metabolites and toxicants. Disinfecting properties of anolyte were detected towards gram-positive and gram-negative
bacteria. The comparison of redox potentials of commercial samples of persulfate and the synthesized anolyte showed that the
redox potential value for the anolyte is much higher than for solutions with the same concentration of commercial persulfate. 相似文献
10.
Artem A. Barabanov Nina V. Semikolenova Michail A. Matsko Ljudmila G. Echevskaya Vladimir A. Zakharov 《Polymer》2010,51(15):3354-1654
The effects of polymerization time and temperature on the molecular weight and molecular weight distribution of polyethylene, produced over homogeneous catalyst bis[N-(3-tert-butyl salicylidene)anilinato]zirconium(IV) dichloride tBu-L2ZrCl2/MAO have been studied. The data on the number of active centers (CP) and propagation rate constants (kP) at different polymerization time have been obtained as well. It was found that at a short polymerization time two types of active centers, producing low molecular weight PE (Mw = (4-10) × 103 g mol−1) are formed. The number of these centers was estimated to be 11% of total zirconium complex and their reactivity is very high (the kP value was found to be 54 × 103 L mol−1 s−1 at 35 °C). High initial activity of the catalyst fell with the increase in polymerization time, whereas the polydispersity values of the resulting PE increase due to formation of new centers, producing high molecular weight PE (Mw = (30-1300) × 103 g mol−1). It was found that the decrease in activity is caused by reducing the initial active centers number and lower reactivity of the new-formed centers (kP = 17 × 103 L mol−1 s−1). 相似文献