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1.
Emma Layton Anna-Marie Fairhurst Sam Griffiths-Jones Richard K. Grencis Ian S. Roberts 《International journal of molecular sciences》2020,21(23)
In eukaryotes, microRNAs (miRNAs) have roles in development, homeostasis, disease and the immune response. Recent work has shown that plant and mammalian miRNAs also mediate cross-kingdom and cross-domain communications. However, these studies remain controversial and are lacking critical mechanistic explanations. Bacteria do not produce miRNAs themselves, and therefore it is unclear how these eukaryotic RNA molecules could function in the bacterial recipient. In this review, we compare and contrast the biogenesis and functions of regulatory RNAs in eukaryotes and bacteria. As a result, we discovered several conserved features and homologous components in these distinct pathways. These findings enabled us to propose novel mechanisms to explain how eukaryotic miRNAs could function in bacteria. Further understanding in this area is necessary to validate the findings of existing studies and could facilitate the use of miRNAs as novel tools for the directed remodelling of the human microbiota. 相似文献
2.
Mohammad Hossein
Abbasi Laura Iapichino Sajad Naderi Lordejani Wil Schilders Nathan van de Wouw 《International journal for numerical methods in engineering》2020,121(23):5178-5199
To circumvent restrictions of conventional drilling methods, such as slow control actions and inability to drill depleted reservoirs, a drilling method called managed pressure drilling (MPD) has been developed. In MPD, single-phase flow processes can be modeled as a feedback interconnection of a high-order linear system and a low-order nonlinear system. These nonlinearities appear locally both inside and at the boundaries of the computational domain. To obtain a fast simulation platform for real-time purposes (eg, online model-based controller implementation), model order reduction is required for MPD. However, the local nonlinearities render applying model order reduction techniques challenging. In this study, a new approach is proposed to deal with such nonlinearities within the reduced basis (RB) context and it is successfully tested on a model for MPD. Contrary to the classical RB technique, the proposed approach not only does not generate nonphysical spikes at the locations of these local nonlinearities but also yields high speedup factors. The obtained reduced-order model can be used for efficient online simulation and controller design for drilling systems with MPD. 相似文献
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4.
Jacobson Nathan S. Kuczmarski Maria A. Kowalski Benjamin A. 《Oxidation of Metals》2020,93(3-4):247-282
Oxidation of Metals - Vaporization often accompanies high-temperature oxidation and corrosion. In this review, vaporization under a vacuum as well as static gas and flowing gas conditions is... 相似文献
5.
2,4-Thiazolidinedione (TZD) is a privileged and highly utilised scaffold for the development of pharmaceutically active compounds. This sulfur-containing heterocycle is a versatile pharmacophore that confers a diverse range of pharmacological activities. TZD has been shown to exhibit biological action towards a vast range of targets interesting to medicinal chemists. In this review, we attempt to provide insight into both the historical conventional and the use of novel methodologies to synthesise the TZD core framework. Further to this, synthetic procedures utilised to substitute the TZD molecule at the activated methylene C5 and N3 position are reviewed. Finally, research into developing clinical agents, which act as modulators of peroxisome proliferator-activated receptors gamma (PPARγ), protein tyrosine phosphatase 1B (PTP1B) and aldose reductase 2 (ALR2), are discussed. These are the three most targeted receptors for the treatment of diabetes mellitus (DM). 相似文献
6.
Electric vehicles (EVs) have a limited driving range compared to conventional vehicles. Accurate estimation of EV's range is therefore a significant need to eliminate “range anxiety” that refers to drivers' fear of running out of energy while driving. However, the range estimators used in the currently available EVs are not sufficiently accurate. To overcome this issue, more accurate range estimation techniques are investigated. Nonetheless, an accurate power‐based EV energy consumption model is crucial to obtain a precise range estimation. This paper describes a study on EV energy consumption modelling. For this purpose, EV modelling is carried out using MATLAB/Simulink software based on a real EV in the market, the BMW i3. The EV model includes vehicle powertrain system and longitudinal vehicle dynamics. The powertrain is modelled using efficiency maps of the electric motor and the power electronics' data available for BMW i3. It also includes a transmission and a battery model (ie, Thevenin equivalent circuit model). A driver model is developed as well to control the vehicle's speed and to represent human driver's behaviour. In addition, a regenerative braking strategy, based on a series brake system, is developed to model the behaviour of a real braking controller. Auxiliary devices are also included in the EV model to improve energy consumption estimation accuracy as they can have a significant impact on that. The vehicle model is validated against published energy consumption values that demonstrates a satisfactory level of accuracy with 2% to 6% error between simulation and experimental results for Environmental Protection Agency and NEDC tests. 相似文献
7.
We discuss the potential benefits, requirements, and implementation challenges of a security-by-design approach in which an integrated development environment plugin assists software developers to write code that complies with secure coding guidelines. We discuss how such a plugin can enable a company's policy-setting security experts and developers to pass their knowledge on to each other more efficiently, and to let developers more effectively put that knowledge into practice. This is achieved by letting the team members develop customized rule sets that formalize coding guidelines and by letting the plugin check the compliance of code being written to those rule sets in real time, similar to an as-you-type spell checker. Upon detected violations, the plugin suggests options to quickly fix them and offers additional information for the developer. We share our experience with proof-of-concept designs and implementations rolled out in multiple companies, and present some future research and development directions. 相似文献
8.
Lee J. Baumgartner Peter Gell Jason D. Thiem Colin Finlayson Nathan Ning 《河流研究与利用》2020,36(4):645-655
Restoration programmes for degraded aquatic ecosystems frequently focus on flow restoration or reinstatement, including recovery targets for volumes of water to be used for environmental benefit. Australia's Murray–Darling Basin is an example of a major system undergoing substantial water reform to balance the needs of competing users, including the environment, within the constraints of an arid climate. This reform revolves around accounting for finite volumes of water that have been shared amongst water users. We argue that while recovering water will provide good outcomes, as a sole intervention, it is not enough to deliver the desired environmental benefits of the reform given the significantly altered state of the catchment. Here, we present 10 measures that could be used to complement planned water recovery actions. These “complementary measures” integrate recovery actions, which when strategically combined with water delivery would significantly enhance water reform efforts to generate environmental outcomes in a highly modified system. 相似文献
9.
10.
Charles W. Bauschlicher Jr. Cameron J. Bodenschatz Dwight L. Myers Nathan S. Jacobson 《Journal of the American Ceramic Society》2020,103(10):5870-5880
Thermodynamic parameters are reported for gaseous hydroxides and oxyhydroxides of Al, Zr, and Y. The structures and vibrational frequencies are calculated using density functional theory with the B3LYP functional. This yields entropies at 298.15 K and heat capacities. The enthalpies are calculated from appropriate reactions and the CCSD(T) (Coupled Cluster, Singles, Doubles, and perturbative Triples) approach. The hydroxide groups are treated as hindered rotors for all species. The results are compared to the limited experimental and theoretical calculations for these species. Finally, the data are put into a database for a free-energy minimizer and the vapor pressures for each species are compared. 相似文献