3D Radiation Therapy Boost Improves the Outcome of Whole Brain Radiation Therapy Treated RPA II Patients with One or Two Brain Metastases

Purpose

to evaluate the role of whole brain radiotherapy (WBRT) and radiation boost (RB) for 208 patients recursive partitioning analysis (RPA) II with 1 or 2 brain metastases (BM) at a single institution.

Methods and Materials

the dose of WBRT was 30 Gy (10 fractions of 3 Gy). One hundred thirty-two patients (63.5%) benefited from RB of 9 Gy in 3 fractions of 3 Gy at the metastatic site. Patients had 1 or 2 BM in 122 (58.7%) and 86 cases (41.3%), respectively.

Results

patients with one or two metastases had similar survival (4.6 and 5.1 months, respectively) (p = 0.4). Median overall survival (OS) for patients treated with WBRT and RB, and with WBRT alone was 5.9 and 3.7 months, respectively (p = 0.03). The 6-, 12- and 24-month OS rates after WBRT and RB were 48.5%, 25% and 10.6%, respectively, while WBRT alone resulted in OS rates of 34%, 22.4% and 3.2%, respectively (p = 0.03). After WBRT and RB, the 6-, 12- and 24-month local control rates were 92%, 82% and 67%, respectively, while they were 81.2%, 75% and 37.5%, respectively, after WBRT alone (p = 0.03). The 6-, 12- and 24-month brain control rates after WBRT and RB were 88.7%, 75.8% and 62%, respectively, and after WBRT alone they were 78.5%, 59% and 37.7%, respectively (p = 0.03).

Conclusion

additional boost delivered with 3D conformal radiotherapy improves local and brain control rates significantly as well as overall survival for RPA II patients with 1 or 2 unresectable BM.     

Study of potential leakage on several stressed fittings for hydrogen pressures up to 700 bar

In order to improve risk analyses and influence the design of the future H₂ systems, an experimental study on “real” leaks qualification and quantification was performed. In H₂ energy applications, fittings appeared as a significant leakage potential and subsequently explosion and flame hazards. Thus, as a part of the “Horizon Hydrogène Energie” French program, four kinds of commercial fittings usually employed on H₂ systems were tested thanks to a new high pressure test bench – designed, setup and operated by INERIS – allowing experiments to be led for H₂ pressures until 700 bar. The fittings underwent defined stresses representative of H₂ systems lifetime and beyond. The associated leaks – when existing – are characterized in terms of flow rate.     

A Dynamic Noise Primitive for Coherent Stylization

We present a new solution for temporal coherence in non‐photorealistic rendering (NPR) of animations. Given the conflicting goals of preserving the 2D aspect of the style and the 3D scene motion, any such solution is a tradeoff. We observe that primitive‐based methods in NPR can be seen as texture‐based methods when using large numbers of primitives, leading to our key insight, namely that this process is similar to sparse convolution noise in procedural texturing. Consequently, we present a new primitive for NPR based on Gabor noise, that preserves the 2D aspect of noise, conveys the 3D motion of the scene, and is temporally continuous. We can thus use standard techniques from procedural texturing to create various styles, which we show for interactive NPR applications. We also present a user study to evaluate this and existing solutions, and to provide more insight in the trade‐off implied by temporal coherence. The results of the study indicate that maintaining coherent motion is important, but also that our new solution provides a good compromise between the 2D aspect of the style and 3D motion.     

Recruitment and training of a sensory expert panel to measure the touch of beverage packages: Issue and methods employed

Although formerly considered an intermediate product, packaging has become a main component of the product and largely contributes to its perceived quality. It is the first contact with consumer. For many years, the food industry has used sensory analysis techniques to improve the gustative and olfactive quality of its products, yet there has been very little application to the packaging. The present article investigates issues involved in the recruitment and training of a sensory tactile expert panel for beverage packaging. The study addresses two important questions: what are the sensory tactile attributes that are usable for packages, and do the hand movements performed by each expert have an impact on the sensory response? The first part presents the research of sensory attributes and the training of two groups on different types of beverage packaging (glass, plastic, aluminum bottles). The performances of both groups have been controlled. In the second part, the impact of hand movements (kind of movement, variation, and strategy of haptic exploration) is demonstrated by a three-step experiment.     

Characterisation of power modules ceramic substrates for reliability aspects

Electronic power devices used for transportation applications (automotive and avionics) experience severe temperature variations which promote their thermal fatigue and failure. For example, for power modules mounted on the engine of an aircraft, temperature variations range from −55 °C (in the worst case of storage before takeoff) to +200 °C (flight). In theses conditions failure (conchoïdal fracture) can occur in DBC substrates. The Weibull approach was used to model the brittle fracture of the ceramic layer from a natural defect. Besides, geometric singularities in the upper ceramic/copper interface are at the origin of cracks, which grow by fatigue and finally bifurcate and break the ceramic layer. With the framework of linear elastic fracture mechanics (LEFM) and using the finite element method, it was possible to analyse how a thermal loading history may modify the risk of failure of the DBC substrate and can increase the fatigue life of a power module. This result shows that the fatigue life and the reliability of power electronic devices could be optimized using a thermo-mechanical approach of the problem and suitable failure criteria.     

Electron-phonon interaction within an unbiased and biased quantumwell

This paper addresses the electron-phonon interaction when a perpendicular electric field is applied across a quantum well (QW). An applied perpendicular electric field redistributes the one-dimensional density of states in position and energy within a QW. The redistribution of the one-dimensional density of states modifies the calculation of the initial and final states in the electron-phonon interaction. The overall result is to increase the scattering rate between the electrons and phonons while adding additional characteristics to the shape of the phonon scattering time     

Determination of the Mg-Rich Phase Boundary of the Binary Mg-Nd Phase Diagram by Means of Atom Probe Tomography

The present paper relates the investigation of the Mg-rich side of the binary Mg-Nd phase diagram by means of Atom Probe Tomography (APT). The solid solubility of Nd in Mg at the temperatures 400, 480, 520 °C has been measured. The results of the current investigation demonstrate that the solid solubility of Nd in Mg is much larger than is usually supposed and presented in more recent Mg-Nd phase diagrams. The data presented in this work can be used for further thermodynamic calculations in order to interpolate the phase boundary between temperature points.     

Effect of the oxygen content in solution on the static and cyclic deformation of titanium foams

It is well known that interstitials affect the mechanical properties of titanium and titanium alloys. Their effects on the fatigue properties of titanium foams have not, however, been documented in the literature. This paper presents the effect of the oxygen content on the static and dynamic compression properties of titanium foams. Increasing the oxygen content from 0.24 to 0.51 wt% O in solution significantly increases the yield strength and reduces the ductility of the foams. However, the fatigue limit is not significantly affected by the oxygen content and falls within the 92 MPa ± 12 MPa range for all specimens investigated in this study. During cyclic loading, deformation is initially coming from cumulative creep followed by the formation of microcracks. The coalescence of these microcracks is responsible for the rupture of the specimens. Fracture surfaces of the specimens having lower oxygen content show a more ductile aspect than the specimens having higher oxygen content.