Alizarin Red S as an electrochemical indicator for saccharide recognition

In addition to the well-established spectroscopic Alizarin Red S (ARS) assay for the determination of binding constants between arylboronic acids and different saccharides, we report the use of ARS as a reporter in an electrochemical set-up. The electrochemical properties of ARS, the binding to phenyl boronic acid (PBA) and the competition with fructose in phosphate buffer at pH 7.4 were investigated by cyclic voltammetry (CV). By choosing a negative scan direction (starting at +0.2 V), a quasi-reversible process was detected at E⁰′ = −0.59V with ΔE_p = 0.1V. An irreversible oxidation peak at +0.42 V could also be detected. These peaks are characterised both as a 2-proton-2-electron transfer and corresponds to the oxidation and reduction of the anthraquinone or the ortho-quinone moiety. After addition of phenylboronic acid a new oxidation peaks occurred at −0.42 V which correlates with the ARS–PBA interaction. The peak current increased with increasing phenylboronic acid concentration according to the release of BA and formation of the ARS–PBA ester. After addition of fructose the peak current decreases again, in proportion to the fructose concentration, enabling the use of ARS as an electrochemical reporter for fructose detection up to 50 mM. Also the interaction with other cis-diol containing compounds such as sorbitol, mannitol, glucose and mannose was investigated and a dependence based on already published binding constants to phenylboronic acid could be shown.     

Photolithographic patterning of organic photodetectors with a non-fluorinated photoresist system

We report on the fabrication of organic photodetectors (OPD) based on isolated islands of P3HT:PCBM. Pattern transfer to the active material was done with photolithography based on non-fluorinated solvents and the excessive organic semiconductor was removed with oxygen plasma reactive ion etching. The photoresist system used was found to be benign to the P3HT:PCBM layer as confirmed by absorption, thickness and roughness measurements. Current–voltage characteristics and external quantum efficiency (EQE) remained unchanged after the patterning process. It was demonstrated that it is possible to photolithographically pattern isolated islands with 200 μm edge length with the same dark current density (<10⁻⁵ A/cm² at −2 V bias voltage) and photocurrent density (>5 × 10⁻³ A/cm² at −2 V). Furthermore, concerning the solar cell performance, the patterned, small-area devices showed power conversion efficiency of 2.1% and fill-factor of 60%. Dark current was observed to depend on the size of the remaining semiconductor island, which was demonstrated on OPDs with diameter of 50 μm. The presented results show the feasibility of fabrication of isolated devices based on organic semiconductors patterned with non-fluorinated photolithography.     

Integration of job shop control systems: A state-of-the-art review

This paper reviews important theoretical and practical developments in job shop control. The distinguishing feature of this paper is the identification and summary of important concepts and procedures useful for incorporation into computerized job shop control systems. The first section briefly examines the job shop control problem, and presents a broad outline of commonly used subproblems and methods. A review of the past work done in the areas of scheduling and sequencing, workload balancing, work flow structure analysis, and job shop capability evaluation is then presented. The final section lists important concepts and procedures for developing computer integrated job shop control systems.     

Vapor Phase Growth of Functional Pentacene Films at Atmospheric Pressure

Compared to traditional vacuum evaporation techniques for small organic molecules, organic vapor phase deposition (OVPD) possesses a extra processing parameter: the pressure of process gas P_ch. Here, the influence of large P_ch variations (from 0.1 mbar to atmospheric pressure) on pentacene thin film growth is explored. OVPD operation at higher P_ch is characterized by lower carrier gas velocities and lower organic diffusivities. These result in an invariance of the material utilization efficiency over the entire pressure span and in an advantageous equilibrium evaporation regime in the source. An increase in P_ch yields rough pentacene layers. Classical nucleation theory is applied to demonstrate how the pressure rise triggers homogeneous nucleation in the gas phase, causing the observed roughening. The use of lower deposition rates, higher dilution flow rates, and higher substrate temperatures result in the suppression of gas phase nucleation and the growth of smooth pentacene films at atmospheric pressure. Using these optimized conditions, state‐of‐the‐art pentacene thin film transistors with saturation mobilities above 0.9 cm²/Vs are reproducibly fabricated. p‐Type circuits are also made and a 19‐stage ring oscillator with a stage delay of 51 μs at a supply voltage of 15 V is demonstrated.     

A silicon test chip for the thermomechanical analysis of MEMS packagings

This paper reports on a method for the investigation of mechanical stress on MEMS sensor and actuator structures due to packaging processes. A silicon test chip is developed and manufactured to validate the simulation results. Finite element analysis (FEA) is used to optimize the geometric parameters and to find a stress sensitive sensor geometry. A diaphragm structure is used as mechanical amplifier for bulk induced stresses during the packaging process. Piezo resistive solid state resistors are doped into the surface of the chip to measure the stress in the diaphragms and at the contact pads being most significant locations for analysis. A high precision ohmmeter was used to measure the resistance prior and past the packaging process. The captured data allows for computation of the resulting stress loads in magnitude. Therefore, a stress evaluation of different packaging technologies is conducted and the impact of the packaging process on reliability can be estimated immediately.     

Central venous oxygen saturation and thoracic admittance during dialysis: new approaches to hemodynamic monitoring

Intradialytic hypotension (IDH) is one of the most important short-term complications to hemodialysis (HD). Inadequate cardiac filling due to a reduction in the central blood volume is believed to be a major etiological factor. The aim of this study was to evaluate whether these pathophysiologic events are reflected in the central venous oxygen saturation (ScO(2)) and thoracic admittance (TA) during dialysis. Twenty ambulatory HD patients, 11 hypotension prone (HP) and 9 hypotension resistant, with central vascular access, were monitored during 3 HD sessions each. ScO(2), TA, finger blood pressure (BP), and relative change in blood volume (DeltaBV) were measured and sampled continuously. The relative TA decrease and DeltaBV were both largest in the HP group (p<0.05 for both), whereas ScO(2) decreased only in HP patients (p<0.001). Baseline TA was lower in the HP group (p<0.01). Changes in ScO(2) and TA correlated much closer than did changes in ScO(2) and DeltaBV (r=0.43 and 0.18, respectively). Our results suggest that an intradialytic decrease in cardiac output, as reflected by a fall in ScO(2), is a common feature to HD patients prone to IDH. In patients using a central vascular access, ScO(2) and TA measurements may be more specific to the pathophysiologic events preceding IDH than DeltaBV-the current standard monitoring method.     

Phase State and Deliquescence Hysteresis of Ammonium-Sulfate-Seeded Secondary Organic Aerosol

The phase state of secondary organic aerosol (SOA) has an impact on its lifetime, composition, and its interaction with water. To better understand the effect of phase state of SOA on climate interactions, we studied the SOA phase state and the effect of its history and report here the phase state and the humidity-induced phase hysteresis of multicomponent-seeded SOA particles produced in a large, continuously stirred tank reactor. We determined the phase state of the particles by their bounced fraction impacting on a smooth substrate in a low-pressure impactor. The particles were composed of ammonium sulfate ([NH₄]₂SO₄) seed and a secondary organic matter (SOM) shell formed from oxidized α-pinene or isoprene. The ammonium sulfate (AS) seed dominated the deliquescence of the α-pinene SOM multicomponent particles, whereas their efflorescence was strongly attenuated by the SOM coating. Particles coated with isoprene SOM showed continuous phase transitions with a lesser effect by the AS seed. The results agree with and independently corroborate contemporary research.

Copyright 2015 American Association for Aerosol Research     

Using elemental ratios to predict the density of organic material composed of carbon, hydrogen, and oxygen

A governing equation was developed to predict the density ρ(org) of organic material composed of carbon, oxygen, and hydrogen using the elemental ratios O:C and H:C as input parameters: ρ(org) = 1000 [(12 + 1(H:C) + 16(O:C)]/[7.0 + 5.0(H:C) + 4.15(O:C)] valid for 750 < ρ(org) < 1900 kg m(-3). Comparison of the actual to predicted ρ(org) values shows that the developed equation has an accuracy of 12% for more than 90% of the 31 atmospherically relevant compounds used in the training set. The equation was further validated for secondary organic material (SOM) produced by isoprene photo-oxidation and by α-pinene ozonolysis. Depending on the conditions of SOM production, ρ(org/SOM) ranged from 1230 to 1460 kg m(-3), O:C ranged from 0.38 to 0.72, and H:C ranged from 1.40 to 1.86. Atmospheric chemistry models that simulate particle production and growth can employ the developed equation to simulate particle physical properties. The equation can also extend atmospheric measurements presented as van Krevelen diagrams to include estimates of the material density of particles and their components. Use of the equation, however, is restricted to particle components having negligible quantities of additional elements, most notably nitrogen.     

大亚湾中微子探测器能量响应非线性的研究

大亚湾反应堆中微子实验利用大型液体闪烁体探测器探测来自反应堆的中微子。液体闪烁体探测器的能量响应非线性研究是准确重建能量的关键。论文详细论述了能量非线性的来源及测量方法,包括在探测器中利用不同能量的γ源进行刻度,利用本底事例进行刻度,以及在实验室开展的针对不同非线性来源的独立测量,最后通过联合拟合的方法给出测量结果并加以讨论。     

N-soliton Solutions to Degenerate Self-induced Transparency

Abstract

For degenerate self-induced transparency with an F = 1 ? F = 0 transition the general N-soliton solution is constructed in terms of determinants. The two-soliton solution is given explicitly, and it is depicted in the limit of non-separating solitons.