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排序方式: 共有395条查询结果,搜索用时 15 毫秒
1.
Rajesh R. Shrestha Barrie R. Bonsal Ashish Kayastha Yonas B. Dibike Christopher Spence 《Journal of Great Lakes research》2021,47(3):677-689
This study assesses snow response in the Assiniboine-Red River basin, located in the Lake Winnipeg watershed, due to anthropogenic climate change. We use a process-based distributed snow model driven by an ensemble of eight statistically downscaled global climate models (GCMs) to project future changes under policy-relevant global mean temperature (GMT) increases of 1.0 °C to 3.0 °C above the pre-industrial period. Results indicate that basin scale seasonal warmings generally exceed the GMT increases, with greater warming in winter months. The majority of GCMs project wetter winters and springs, and drier summers, while autumn could become either drier or wetter. An analysis of snow water equivalent (SWE) responses under GMT changes reveal higher correlations of snow cover duration (SCD), snowmelt rate, maximum SWE (SWEmax) and timing of SWEmax with winter and spring temperatures compared to precipitation, implying that these variables are predominantly temperature controlled. Consequently, under the GMT increases from 1.0 °C to 3.0 °C, the basin will experience successively shorter SCD, slower snowmelt, smaller monthly SWE and SWEmax, earlier SWEmax, and a transition from snow-dominated to rain-snow hybrid regime. Further, while the winter precipitation increases for some GCMs compensate the temperature-driven changes in SWE, the increases for most GCMs occur as rainfall, thus limiting the positive contribution to snow storage. Overall, this study provides a detailed diagnosis of the snow regime changes under the policy-relevant GMT changes, and a basis for further investigations on water quantity and quality changes. 相似文献
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Dr. Alireza Ghanbarpour Dr. Elizabeth M. Santos Dr. Cody Pinger Dr. Zahra Assar Seyedmehdi Hossaini Nasr Prof. Chrysoula Vasileiou Prof. Dana Spence Babak Borhan Prof. James H. Geiger 《Chembiochem : a European journal of chemical biology》2020,21(22):3192-3196
Domain-swapping is a mechanism for evolving new protein structure from extant scaffolds, and has been an efficient protein-engineering strategy for tailoring functional diversity. However, domain swapping can only be exploited if it can be controlled, especially in cases where various folds can coexist. Herein, we describe the structure of a domain-swapped trimer of the iLBP family member hCRBPII, and suggest a mechanism for domain-swapped trimerization. It is further shown that domain-swapped trimerization can be favored by strategic installation of a disulfide bond, thus demonstrating a strategy for fold control. We further show the domain-swapped trimer to be a useful protein design template by installing a high-affinity metal binding site through the introduction of a single mutation, taking advantage of its threefold symmetry. Together, these studies show how nature can promote oligomerization, stabilize a specific oligomer, and generate new function with minimal changes to the protein sequence. 相似文献
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Shengfu Yang Cheng Feng Daniel Spence Aula M. A. A. Al Hindawi Elspeth Latimer Andrew M. Ellis Chris Binns Davide Peddis Sarnjeet S. Dhesi Liying Zhang Yafei Zhang Kalliopi N. Trohidou Marianna Vasilakaki Nikolaos Ntallis Ian MacLaren Frank M. F. de Groot 《Advanced materials (Deerfield Beach, Fla.)》2017,29(1)
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Raffaele Montella Giulio Giunta Giuliano Laccetti Marco Lapegna Carlo Palmieri Carmine Ferraro Valentina Pelliccia Cheol-Ho Hong Ivor Spence Dimitrios S. Nikolopoulos 《International journal of parallel programming》2017,45(5):1142-1163
The astonishing development of diverse and different hardware platforms is twofold: on one side, the challenge for the exascale performance for big data processing and management; on the other side, the mobile and embedded devices for data collection and human machine interaction. This drove to a highly hierarchical evolution of programming models. GVirtuS is the general virtualization system developed in 2009 and firstly introduced in 2010 enabling a completely transparent layer among GPUs and VMs. This paper shows the latest achievements and developments of GVirtuS, now supporting CUDA 6.5, memory management and scheduling. Thanks to the new and improved remoting capabilities, GVirtus now enables GPU sharing among physical and virtual machines based on x86 and ARM CPUs on local workstations, computing clusters and distributed cloud appliances. 相似文献
7.
Ying K. Leung Robert Spence Mark D. Apperley 《International journal of human-computer interaction》2013,29(1):79-98
Presentation techniques for topological networks can be broadly classified as distortion‐oriented and nondistortion‐oriented. Although there has been a growing interest in applying various distortion‐oriented techniques, the application of an earlier example, the bifocal display, has so far been underexploited. This article describes a number of human‐computer interface techniques potentially relevant to the presentation and navigation of topological networks associated with transport systems, and describes a preliminary experimental study of a number of techniques for presenting the London Underground map as part of a real‐time information system for travelers. 相似文献
8.
Betina Piqueras-Fiszman Zoe LaughlinMark Miodownik Charles Spence 《Food quality and preference》2012,24(1):24-29
This study investigated the effect that the taste of certain metals has on the perception of food. Four spoons plated with different metals (gold, copper, zinc, and stainless steel) were used to taste cream samples having different tastes: sweet, sour, bitter, salty, and plain. The results revealed that the zinc and copper spoons, in addition to transferring a somewhat metallic and bitter taste, enhanced to a greater or lesser extent, each cream’s dominant taste. Contrary to our expectations, the metallic taste of the copper and zinc spoons did not seem to affect the pleasantness of the samples significantly. These findings reveal that the effect that the metals from which cutlery can be made have on food perception differs from that found when the metal salts are added to the composition of the food itself. 相似文献
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We describe a liquid jet injector system developed to deliver fully solvated microscopic target species into a probe beam under either vacuum or ambient conditions. The injector was designed specifically for x-ray scattering studies of biological nanospecies using x-ray free electron lasers and third generation synchrotrons, but is of interest to any application in which microscopic samples must be delivered in a fully solvated state and with microscopic precision. By utilizing a gas dynamic virtual nozzle (GDVN) to generate a sample-containing liquid jet of diameter ranging from 300 nm to 20 μm, the injector avoids the clogging problems associated in this size range with conventional Rayleigh jets. A differential pumping system incorporated into the injector shields the experimental chamber from the gas load of the GDVN, making the injector compatible with high vacuum systems. The injector houses a fiber-optically coupled pump laser to illuminate the jet for pump-probe experiments and a hermetically sealed microscope to observe the liquid jet for diagnostics and alignment during operation. This injector system has now been used during several experimental runs at the Linac Coherent Light Source. Recent refinements in GDVN design are also presented. 相似文献
10.
A sufficiently thin column of liquid was produced to permit penetration with a 200 keV electron beam as evidenced by the observation of diffraction rings due to the intermolecular spacing of the liquid samples. For liquid thickness below 800 nm, the diffraction rings became visible above the inelastic background. Studies were carried out in the environmental chamber of a transmission electron microscope using water and isopropanol. 相似文献