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排序方式: 共有705条查询结果,搜索用时 15 毫秒
1.
Alfonso Martín-Bernab Josep Tarrag-Celada Valrie Cunin Sylvie Michelland Roldn Corts Johann Poignant Cyril Boyault Walid Rachidi Sandrine Bourgoin-Voillard Marta Cascante Michel Seve 《International journal of molecular sciences》2021,22(7)
Growing evidence is showing that acetylation plays an essential role in cancer, but studies on the impact of KDAC inhibition (KDACi) on the metabolic profile are still in their infancy. Here, we analyzed, by using an iTRAQ-based quantitative proteomics approach, the changes in the proteome of KRAS-mutated non-small cell lung cancer (NSCLC) A549 cells in response to trichostatin-A (TSA) and nicotinamide (NAM) under normoxia and hypoxia. Part of this response was further validated by molecular and biochemical analyses and correlated with the proliferation rates, apoptotic cell death, and activation of ROS scavenging mechanisms in opposition to the ROS production. Despite the differences among the KDAC inhibitors, up-regulation of glycolysis, TCA cycle, oxidative phosphorylation and fatty acid synthesis emerged as a common metabolic response underlying KDACi. We also observed that some of the KDACi effects at metabolic levels are enhanced under hypoxia. Furthermore, we used a drug repositioning machine learning approach to list candidate metabolic therapeutic agents for KRAS mutated NSCLC. Together, these results allow us to better understand the metabolic regulations underlying KDACi in NSCLC, taking into account the microenvironment of tumors related to hypoxia, and bring new insights for the future rational design of new therapies. 相似文献
2.
Florence Lacoste Patrick Carré Sylvie Dauguet Catarina Petisca Fernando Campos Daniel Ribera 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2020,37(9):1491-1502
ABSTRACT Processing Factors (PFs) reflect the concentration or dilution of pesticide residues resulting from food processing. PFs are key elements to demonstrate the compliance of processed foods with Maximum residue levels (MRLs) as set by Regulation 396/2005. While efforts have been made by the European Food Safety Authority (EFSA) and by national authorities to compile PFs from processing studies, such PFs are not available for all pesticides/processed product combinations. The EU vegetable oil and proteinmeal industry association (FEDIOL) has therefore developed a theoretical approach to approximate MRLs in crude vegetable oils and fats, based on the partition coefficient (log Pow) of the pesticides and on the oil content of the raw materials. To substantiate this approach, a pilot-scale processing study was initiated with rapeseeds spiked with selected pesticides and the experimental PFs for these pesticides determined. The aims of this study were (i) to study the reliability of pilot-scale conditions for PF determination and (ii) to assess the experimental PFs obtained in comparison to the theoretical PFs proposed by FEDIOL. This study demonstrated that production yields obtained for crude oil and meal in this processing study are similar to those in industrial processes even if differences were observed in the individual production steps (mechanical or solvent extraction steps). The experimental PFs obtained confirmed that the chosen fat-soluble pesticides did concentrate in the oil fraction. For metalaxyl-M having a log Pow lower than 3, a partitioning between the oil and the meal was observed, as expected. By comparing the experimental PFs and theoretical PFs, it can be concluded that the FEDIOL approach can be recommended as a suitable tool when PFs derived from specific processing studies are missing. Similar studies on pesticides with wider ranges of log Pow are required in order to complete our conclusions on default PFs for vegetable oils. 相似文献
3.
Neska El Haouij Raja Ghozi Jean‐Michel Poggi Sylvie Sevestre‐Ghalila Mriem Jaïdane 《Quality and Reliability Engineering International》2019,35(5):1502-1513
This paper characterizes stress levels via a self‐similarity analysis of the electrodermal activity (EDA) collected in a real‐world driving context. To characterize the EDA richness over scales, the fractional Brownian motion (FBM) process and its corresponding exponent H, estimated via a wavelet‐based approach, are used. Specifically, an automatic scale range selection is proposed in order to detect the linearity in a log scale diagram. The procedure is applied to the EDA signals, from the open database drivedb, originally captured on the foot and the hand of the drivers during a real‐world driving experiment, designed to evoke different levels of arousal and stress. The estimated Hurst exponent H offers a distinction in stress levels when driving in highway versus city, with a reference to restful state of minimal stress level. Specifically, the estimated H values tend to decrease when the driving environmental complexity increases. In addition, the estimated H values on the foot EDA signals allow a better characterization of the driving task than that of hand EDA. The self‐similarity analysis was applied to various physiological signals in literature but not to the EDA so far, a signal which was found to correlate most with human affect. The proposed analysis could be useful in real‐time monitoring of stress levels in urban driving spaces, among other applications. 相似文献
4.
Rositi Hugo Appadoo Owen Kevin Mestre Daniel Valarier Sylvie Ombret Marie-Claire Gadea-Deschamps Émilie Barret-Grimault Christine Lohou Christophe 《Multimedia Tools and Applications》2021,80(2):1945-1967
Multimedia Tools and Applications - Microsoft has recently released a mixed reality headset called HoloLens. This semi-transparent visor headset allows the user who wears it to view the projection... 相似文献
5.
Dr. Sophie Vichier-Guerre Dr. Therese C. Ku Dr. Sylvie Pochet Prof. Katherine L. Seley-Radtke 《Chembiochem : a European journal of chemical biology》2020,21(10):1412-1417
The structurally unique “fleximer” nucleosides were originally designed to investigate how flexibility in a nucleobase could potentially affect receptor–ligand recognition and function. Recently they have been shown to have low-to-sub-micromolar levels of activity against a number of viruses, including coronaviruses, filoviruses, and flaviviruses. However, the synthesis of distal fleximers in particular has thus far been quite tedious and low yielding. As a potential solution to this issue, a series of proximal fleximer bases (flex-bases) has been successfully coupled to both ribose and 2′-deoxyribose sugars by using the N-deoxyribosyltransferase II of Lactobacillus leichmannii (LlNDT) and Escherichia coli purine nucleoside phosphorylase (PNP). To explore the range of this facile approach, transglycosylation experiments on a thieno-expanded tricyclic heterocyclic base, as well as several distal and proximal flex-bases were performed to determine whether the corresponding fleximer nucleosides could be obtained in this fashion, thus potentially significantly shortening the route to these biologically significant compounds. The results of those studies are reported herein. 相似文献
6.
Sandrine Gomes Elodie Petit Lawrence Frezet Jean-Marie Nedelec Ameni Gharzouni Sylvie Rossignol Guillaume Renaudin 《Journal of the American Ceramic Society》2020,103(10):5813-5824
The thermal behavior of a model MK-based K-geopolymer was investigated between room temperature and 1400°C in order to evaluate its potentiality for high-temperature applications. The purpose of our study was to monitor the behavior of a geopolymer during a temperature rise in order to better understand its variations with respect to temperature. The works from the present paper focus only changes in the porous network; it follows a first part devoted to variations in the mineral matrix. The results obtained here show that the geopolymer material preserves its porous integrity up to 800°C, while maintaining the reversibility of water exchanges corresponding to about 25 weight percent. Together with the results of part 1, the findings of this study allow us to affirm that geopolymer materials are only very little affected by temperatures up to 800°C, or even 900°C (keeping its mesoporous amorphous structure). 相似文献
7.
Earth to air heat exchanger (EAHE) is a well‐known technique used to preheat or precool outdoor air before blowing it into a building. However, its geometry is often very simple as it consists in one or multiple straight pipes, while more complex arrangements can be found in heat exchangers design. In this paper, we explore the advantage of designing an EAHE as a network through the Constructal law point of view. A methodology is first proposed to design a single pipe EAHE when the need is defined in terms of cooling power, overall efficiency and enthalpy difference between the inlet air and the ground. Next, the single pipe EAHE is used as a reference for designing a tree‐shaped network under the constraint of identical fluid volume and cooling power. The geometrical features are allowed to change for the different branches of the network. The network coefficient of performance is found to increase significantly with the bifurcation level, illustrating the superior performances of the network. This approach was found to be robust as the improvements were not depending on the cooling demand or the environmental conditions. However, further work is needed to move from this theoretical result to practical considerations. 相似文献
8.
Sulphonated anthraquinones are known to be recalcitrant to biodegradation and are not eliminated by traditional wastewater treatment plants, leading to their accumulation in fresh water. Due to the high cost and limited efficiency of existing physical-chemical treatments, alternative cheaper processes are required to remove these compounds from industrial effluents. Four plant species were tested under hydroponic conditions for their ability to treat model effluents contaminated with mono- and disulphonated anthraquinones. Among them, Rheum rabarbarum (rhubarb) showed the most promising results and was chosen for further investigation. The apparent transpiration stream concentration factor obtained with this plant species reached up to 2.5, indicating a strong phytotreatment potential that should be further explored then exploited. 相似文献
9.
The removal of progesterone by ozone in aqueous solution was studied in this work. The absolute rate constant was evaluated and first by-products were identified. The reaction was studied in the 2.0-8.0 pH range and was found to be a second-order reaction, first-order relative to each compound concentration. The rate constant, determined by kinetic experiments in presence of an OH radical scavenger (tert-butanol), was independent of pH. The value was evaluated to be equal to 480+/-30 M(-1)s(-1) by two kinetic methods. Mass spectrometry analyses were performed to investigate primary degradation products generated by the reaction of ozone with progesterone. Two by-products were evidenced. According to these results, a degradation pathway of progesterone reacting with ozone was proposed. 相似文献
10.
Phase structure and mechanical properties of PP/EPR/CaCO3 nanocomposites: Effect of particle's size and treatment 下载免费PDF全文
Calcium carbonate (CaCO3) reinforced polypropylene/ethylene propylene rubber (PP/EPR) copolymer composites for automotive use were developed by means of extrusion and injection molding process. Three kinds of CaCO3 (stearic acid treated and untreated) nanoparticles and microparticles were used as fillers. The influence of stearic acid, particle size, and filler content on the state distribution and morphology were investigated by SEM and rheological measurements. Two different morphologies were observed: EPR and CaCO3 dispersed in the PP matrix and a core shell structure, depending on the interactions between EPR and CaCO3. Toughening mechanisms and mechanical properties of the different systems were investigated. Significant improvement in tensile modulus is observed in all composites, depending on filler content. Elongation and notched impact strength were drastically decreased, especially for composites with nano CaCO3. Better impact properties were obtained with low content of treated particles, showing the importance of filler treatment. POLYM. ENG. SCI., 55:2859–2868, 2015. © 2015 Society of Plastics Engineers 相似文献