Functional Dysregulations in CA1 Hippocampal Networks of a 3-Hit Mouse Model of Schizophrenia

For a better translation from treatment designs of schizophrenia to clinical efficiency, there is a crucial need to refine preclinical animal models. In order to consider the multifactorial nature of the disorder, a new mouse model associating three factors (genetic susceptibility—partial deletion of the MAP6 gene, early-life stress—maternal separation, and pharmacological treatment—chronic Δ-9-tetrahydrocannabinol during adolescence) has recently been described. While this model depicts a schizophrenia-like phenotype, the neurobiological correlates remain unknown. Synaptic transmission and functional plasticity of the CA1 hippocampal region of male and female 3-hit mice were therefore investigated using electrophysiological recordings on the hippocampus slice. While basal excitatory transmission remained unaffected, NMDA receptor (NMDAr)-mediated long-term potentiation (LTP) triggered by theta-burst (TBS) but not by high-frequency (HFS) stimulation was impaired in 3-hit mice. Isolated NMDAr activation was not affected or even increased in female 3-hit mice, revealing a sexual dimorphism. Considering that the regulation of LTP is more prone to inhibitory tone if triggered by TBS than by HFS, the weaker potentiation in 3-hit mice suggests a deficiency of intrinsic GABA regulatory mechanisms. Indeed, NMDAr activation was increased by GABA_A receptor blockade in wild-type but not in 3-hit mice. This electrophysiological study highlights dysregulations of functional properties and plasticity in hippocampal networks of 3-hit mice, one of the mechanisms suspected to contribute to the pathophysiology of schizophrenia. It also shows differences between males and females, supporting the sexual dimorphism observed in the disorder. Combined with the previously reported study, the present data reinforce the face validity of the 3-hit model that will help to consider new therapeutic strategies for psychosis.     

Braking wind in Australia: A critical evaluation of the renewable energy target

This paper provides a critical evaluation of Australia’s new Renewable Energy Target (RET) program with respect to its capacity to support wind power development. Four structural flaws associated with the RET which undermine its effectiveness as a catalyst for technological change in the electricity sector are discussed: (i) the inclusion of waste coal mine gas (WCMG) as an eligible fuel source which acts as an indirect coal industry subsidy, (ii) program duration which is too short and ill-structured, (iii) a multiplier that is well-intended to support small-scale renewable technologies but which creates “phantom capacity”, and (iv) the capped target of 45,000 GWh which will stymie long-term wind power market investment. The paper concludes with recommendations which stress the importance of passing effective Carbon Pollution Renewable Scheme (CPRS) legislation to offset the weaknesses associated with the RET. If an effective CPRS cannot be implemented, the paper recommends that amendments be made to the RET to (i) remove WCMG from the list of approved alternative energy sources, and (ii) extend the RET targets to reach 120,000 GWh by 2030.     

Fossils, molecules and embryos: new perspectives on the Cambrian explosion

The Cambrian explosion is named for the geologically sudden appearance of numerous metazoan body plans (many of living phyla) between about 530 and 520 million years ago, only 1.7% of the duration of the fossil record of animals. Earlier indications of metazoans are found in the Neoproterozic; minute trails suggesting bilaterian activity date from about 600 million years ago. Larger and more elaborate fossil burrows appear near 543 million years ago, the beginning of the Cambrian Period. Evidence of metazoan activity in both trace and body fossils then increased during the 13 million years leading to the explosion. All living phyla may have originated by the end of the explosion. Molecular divergences among lineages leading to phyla record speciation events that have been earlier than the origins of the new body plans, which can arise many tens of millions of years after an initial branching. Various attempts to date those branchings by using molecular clocks have disagreed widely. While the timing of the evolution of the developmental systems of living metazoan body plans is still uncertain, the distribution of Hox and other developmental control genes among metazoans indicates that an extensive patterning system was in place prior to the Cambrian. However, it is likely that much genomic repatterning occurred during the Early Cambrian, involving both key control genes and regulators within their downstream cascades, as novel body plans evolved.     

The founding of the Psychological Laboratory, University College London: "Dear Galton…Yours truly, J Sully."

The events leading up to the founding of the Psychological Laboratory at University College London are examined in the light of correspondence from James Sully to Francis Galton. The correspondence reveals the dependence of Sully on Galton for detailed advice at every stage of the process, possible reasons for which are discussed. It also provides sufficient clues to enable identification of a hitherto anonymous donor. Although Galton may have inspired and advised on the initial setting up of the laboratory, his influence on its work did not become apparent until after his death. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comparison of moisture-dependent orthotropic Young’s moduli of Chinese fir wood determined by ultrasonic wave method and static compression or tension tests

Wood with distinctively different properties in the longitudinal, radial and tangential directions exhibits a strong moisture-dependent material characteristic in the elastic range. The purpose of this study was to analyze the orthotropic elastic properties of Chinese fir wood [Cunninghamia lanceolata (Lamb.) Hook] determined at different moisture conditions using an ultrasonic wave propagation method. The results were compared with those obtained by the traditional static compression or tension tests. The results confirm that the stiffness coefficients obtained by the ultrasound without considering the complete stiffness matrix show significantly higher values than the compression or tension Young’s moduli in all the three anatomical directions at each specific MC. The differences between stiffness coefficients and Young’s moduli were significantly reduced by corrections with Poisson ratio. Only in tangential direction, the Young’s moduli with Poisson ratio correction are statistically equivalent to the Young’s moduli obtained by compression and tension.     

Orientated crystallization in drawn thermoplastic polyimide modified by carbon nanofibers

The solid state crystallization in drawn thermoplastic polyimide films is studied as a function of draw ratio (DR) under the effect of vapor grown carbon fiber nanoinclusions. The nucleating effect of the nanoinclusions coupled with the orientation effect of drawing generates a unique orientated layered lamellar structure, characteristic of smectic‐like mesophase. The degree of draw induced orientated crystallization increases with the content of nanoinclusions and with the DR, and is reflected in the mechanical behavior of the film. Generally, the Young's modulus and the yield point of the drawn crystalline films in the drawing direction are significantly higher compared with the noncrystalline counterparts. POLYM. ENG. SCI., 2009. © 2008 Society of Plastics Engineers