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排序方式: 共有351条查询结果,搜索用时 31 毫秒
1.
Veronika Stahl Yuan Shi Werner Kraft Tim Lanz Peter Vetter Raouf Jemmali Fiona Kessel Dietmar Koch 《International Journal of Applied Ceramic Technology》2020,17(5):2040-2050
Thanks to their high energy density and thermal conductivity, metallic Phase Change Materials (mPCM) have shown great potential to improve the performance of thermal energy storage systems. However, the commercial application of mPCM is still limited due to their corrosion behavior with conventional container materials. This work first addresses on a fundamental level, whether carbon-based composite-ceramics are suitable for corrosion critical components in a thermal storage system. The compatibility between the mPCM AlSi12 and the Liquid Silicon Infiltration (LSI)-based carbon fiber reinforced silicon carbide (C/C-SiC) composite is then investigated via contact angle measurements, microstructure analysis, and mechanical testing after exposure. The results reveal that the C/C-SiC composite maintains its mechanical properties and microstructure after exposure in the strongly corrosive mPCM. Based on these results, efforts were made to design and manufacture a container out of C/C-SiC for the housing of mPCM in vehicle application. The stability of the component filled with mPCM was proven nondestructively via computer tomography (CT). Successful thermal input- and output as well as thermal storage ability were demonstrated using a system calorimeter under conditions similar to the application. The investigated C/C-SiC composite has significant application potential as a structural material for thermal energy storage systems with mPCM. 相似文献
2.
Veronika Borutinskait? Rūta Navakauskien? 《International journal of molecular sciences》2015,16(8):18252-18269
Today, cancer is understood as an epigenetic as well as genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. Proteins such as histone deacetylases (HDACs) that cause modifications of histones and other proteins can be targets for novel anticancer agents. Recently, interest in compounds that can inhibit HDACs increased, and now there are many HDACs inhibitors (HDACIs) available with different chemical structures, biological and biochemical properties; hopefully some of them will succeed, probably in combination with other agents, in cancer therapies. In our study we focused on the novel HDACI–BML-210. We found that BML-210 (N-phenyl-Nʹ-(2-Aminophenyl)hexamethylenediamide) inhibits the growth of NB4 cells in dose- and time-dependent manner. In this study we also examined how expression and activity of HDACs are affected after leukemia cell treatment with BML-210. Using a mass spectrometry method we identified proteins that changed expression after treatment with BML-210. We prepared RT-PCR analysis of these genes and the results correlated with proteomic data. Based on these and other findings from our group, we suggest that HDACIs, like BML-210, can be promising anticancer agents in promyelocytic leukemia treatment. 相似文献
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4.
Bilge N. Altay Veronika Husovska Alexandra Pekarovicova Paul D. Fleming 《Color research and application》2019,44(6):910-916
Unused base inks that are not going to be used for printing production are considered to be hazardous materials. Their disposal is expensive, and strict environmental regulations should be followed for their disposal. As an alternative, this article describes how spectral data of unused base inks can be gathered and mixed to generate new colors to incorporate them back to print production for small‐volume jobs. In this study, 30 different Pantone colors were selected as target colors. The CIE L*a*b* spectral data of Pantone colors and unused base inks were gathered via a spectrophotometer. A commercial formulation software, based on multiflux theory and CIE L*a*b* color space, was used to formulate ink recipes that contained the base inks. To quantify the performance of ink recipes, they were mixed and printed using an offset printability tester. The CIELAB ΔE*ab metric, developed by CIE, was used to detect the visual differences between the target Pantone Color and printed colors. 相似文献
5.
Pavel Diko Renáta Pagáčová Katarína Zmorayová Veronika Kuchárová Liudmila Vojtková Vitaliy Antal Viktor Kavečanský 《Journal of the American Ceramic Society》2021,104(2):740-752
Barium cerate (BaCeO3) is one of the possible additions to bulk YBa2Cu3O7 single-grain superconductors to suppress the growth of Y2BaCuO5 (Y211) particles. This paper investigates the synthesis of barium cerate powder and its use in YBa2Cu3O7 bulk superconductors. Crystalline barium cerate was synthesized by solid-state reaction, by co-precipitation of oxalates and by sol-gel method. Final calcination was held in air or in vacuum. It is shown that the most efficient in refining Y211 is nanocrystalline barium cerate prepared by sol-gel method calcined in vacuum. The effective refinement of Y211 particles occurred over the entire interval of nanocrystalline BaCeO3 addition from 0.38 to 1.90 wt%. The optimal concentration of nanosize barium cerate was determined, microstructure and superconducting properties were characterized. The effect of Y211 content on trapped field in YBCO bulks with addition of nanocrystalline barium cerate is shown. 相似文献
6.
Gtz Hüsken Stephan Pirskawetz Dietmar Meinel Veronika Babski Hans‐Carsten Kühne 《Bautechnik》2016,93(10):711-716
Methods for analyzing the fracture behavior of high‐strength steel fiber‐reinforced concretes High‐strength and ultra‐high strength fiber‐reinforced concretes are most suitable for applications with extreme mechanical loads. These extreme conditions require a ductile behavior under tensile loading, which is obtained solely by the addition of steel fibers and their working mechanism. Profound know ledge on the working mechanism of the steel fibers is necessary for optimizing this material. Usually, this knowledge is obtained by means of classical measuring techniques of destructive tests. Adopting measuring techniques from non‐destructive material testing helps to analyze and to identify the different stages of the fracture mechanism of high‐strength and ultra‐high strength fiber‐reinforced concretes in detail. The application of different non‐destructive measuring techniques is shown exemplary on tensile tests conducted on an ultra‐high strength fiber‐reinforced concrete and its applicability for analyzing the fracture behavior is discussed. The main focus is on the characterization of the relevant failure modes under tensile loading by the different measuring techniques and the comparison with classical measuring techniques (e. g. extensometer). The tensile tests have been analyzed by optical deformation measurements using digital image correlation (DIC), acoustic emission analysis (AE), and 3D computed tomography (CT). 相似文献
7.
Dr. Kornelia Hardes Dr. Gero L. Becker Dr. Yinghui Lu Dr. Sven O. Dahms Susanne Köhler Dr. Wolfgang Beyer Prof. Kirsten Sandvig Dr. Hiroyuki Yamamoto Prof. Iris Lindberg Lisa Walz Dr. Veronika von Messling Dr. Manuel E. Than Prof. Wolfgang Garten Prof. Torsten Steinmetzer 《ChemMedChem》2015,10(7):1218-1231
New peptidomimetic furin inhibitors with unnatural amino acid residues in the P3 position were synthesized. The most potent compound 4‐guanidinomethyl‐phenylacteyl‐Arg‐Tle‐Arg‐4‐amidinobenzylamide (MI‐1148) inhibits furin with a Ki value of 5.5 pM . The derivatives also strongly inhibit PC1/3, whereas PC2 is less affected. Selected inhibitors were tested in cell culture for antibacterial and antiviral activity against infectious agents known to be dependent on furin activity. A significant protective effect against anthrax and diphtheria toxin was observed in the presence of the furin inhibitors. Furthermore, the spread of the highly pathogenic H5N1 and H7N1 avian influenza viruses and propagation of canine distemper virus was strongly inhibited. Inhibitor MI‐1148 was crystallized in complex with human furin. Its N‐terminal guanidinomethyl group in the para position of the P5 phenyl ring occupies the same position as that found previously for a structurally related inhibitor containing this substitution in the meta position, thereby maintaining all of the important P5 interactions. Our results confirm that the inhibition of furin is a promising strategy for a short‐term treatment of acute infectious diseases. 相似文献
8.
9.
Xiao‐Hua Qin Krystyna Labuda Jie Chen Veronika Hruschka Anna Khadem Robert Liska Heinz Redl Paul Slezak 《Advanced functional materials》2015,25(42):6606-6617
Several hemostatic strategies rely on the use of blood components such as fibrinogen and thrombin, which suffer from high cost and short shelf‐life. Here, a cost‐effective synthetic biomaterial is developed for rapid local hemostasis. Instead of using thrombin, thrombin‐receptor‐agonist‐peptide‐6 (TRAP6) is covalently engineered in polyvinyl alcohol (PVA) hydrogels. Soluble PVA‐TRAP6 is first prepared by covalent attachment of cysteine‐containing TRAP6 onto the backbone of PVA‐norbornenes (PVA‐NB) through photoconjugation. Cytotoxicity studies using C2C12 myoblasts indicate that PVA‐NB and PVA‐TRAP6 are nontoxic. Thromboelastography reveals that hemostatic activity of TRAP6 is retained in conjugated form, which is comparable to free TRAP6 solutions with equal concentrations. A 0.1% PVA‐TRAP6 solution can shorten the clotting time (CT) to ca. 45% of the physiological CT. High platelet‐activating efficiency is further confirmed by platelet aggregation assay and flow cytometry (FACS). For potential clinical applications, TRAP6‐presenting hydrogel particulates (PVA‐TRAP6‐P) are developed for local platelet activation and hemostasis. PVA‐TRAP6‐P is prepared by biofunctionalization of photopolymerized PVA‐NB hydrogel particulates (PVA‐NB‐P) with TRAP6. It is demonstrated that PVA‐TRAP6‐P can effectively shorten the CT to ca. 50%. FACS shows that PVA‐TRAP6‐P can activate platelets to a comparable extent as soluble TRAP6 control. Altogether, PVA‐TRAP6‐P represents a promising class of biomaterials for safe hemostasis and wound healing. 相似文献
10.
Paola Songia Mattia Chiesa Valentina Alfieri Ilaria Massaiu Donato Moschetta Veronika Myasoedova Vincenza Valerio Laura Fusini Paola Gripari Marco Zanobini Paolo Poggio 《International journal of molecular sciences》2021,22(4)
Mitral valve prolapse (MVP) associated with severe mitral regurgitation is a debilitating disease with no pharmacological therapies available. MicroRNAs (miRNA) represent an emerging class of circulating biomarkers that have never been evaluated in MVP human plasma. Our aim was to identify a possible miRNA signature that is able to discriminate MVP patients from healthy subjects (CTRL) and to shed light on the putative altered molecular pathways in MVP. We evaluated a plasma miRNA profile using Human MicroRNA Card A followed by real-time PCR validations. In addition, to assess the discriminative power of selected miRNAs, we implemented a machine learning analysis. MiRNA profiling and validations revealed that miR-140-3p, 150-5p, 210-3p, 451a, and 487a-3p were significantly upregulated in MVP, while miR-223-3p, 323a-3p, 340-5p, and 361-5p were significantly downregulated in MVP compared to CTRL (p ≤ 0.01). Functional analysis identified several biological processes possible linked to MVP. In addition, machine learning analysis correctly classified MVP patients from CTRL with high accuracy (0.93) and an area under the receiving operator characteristic curve (AUC) of 0.97. To the best of our knowledge, this is the first study performed on human plasma, showing a strong association between miRNAs and MVP. Thus, a circulating molecular signature could be used as a first-line, fast, and cheap screening tool for MVP identification. 相似文献