Alice,Finnegan&Oliver 还记得没它们之前日子是什么样吗

正加拿大摄影师Holly SissonMonica Sisson这是一个让人"质壁分离"的家庭,两猫一狗,主人都是摄影师,住在加拿大的多伦多市。在她们的照片中,生活平淡可爱又满满当当,我们无法想象,如果这些画面里没有它们,会是什么样子。     

Pro-Resolving Lipid Mediator Resolvin E1 Mitigates the Progress of Diethylnitrosamine-Induced Liver Fibrosis in Sprague-Dawley Rats by Attenuating Fibrogenesis and Restricting Proliferation

Liver fibrosis is a complex process associated to most types of chronic liver disease, which is characterized by a disturbance of hepatic tissue architecture and the excessive accumulation of extracellular matrix. Resolvin E1 (RvE1) is a representative member of the eicosapentaenoic omega-3 lipid derivatives, and is a drug candidate of the growing family of endogenous resolvins. Considering the aforementioned, the main objective of this study was to analyze the hepatoprotective effect of RvE1 in a rat model of liver fibrosis. Male Sprague-Dawley rats received diethylnitrosamine (DEN, 70 mg/mg body weight intraperitoneally (i.p)) as an inductor of liver fibrosis once weekly and RvE1(100 ng/body weight i.p) twice weekly for four weeks. RvE1 suppressed the alterations induced by DEN, normalizing the levels of alanine aminotransferase (ALT), albumin, and lactate dehydrogenase (LDH), and ameliorated DEN injury by decreasing the architecture distortion, inflammatory infiltration, necrotic areas, and microsteatosis. RvE1 also limited DEN-induced proliferation through a decrease in Ki67-positive cells and cyclin D1 protein expression, which is related to an increase of the levels of cleaved caspase-3. Interestingly, we found that RvE1 promotes higher nuclear translocation of nuclear factor κB (NF-κB)p65 than DEN. RvE1 also increased the levels of nuclear the nuclear factor erythroid 2–related factor 2 (Nrf2), but with no antioxidant effect, measured as an increase in glutathione disulfide (GSSG) and a decrease in the ratio of glutathione (GSH)/GSSG. Taken together, these results suggest that RvE1 modulates the fibrogenesis, steatosis, and cell proliferation in a model of DEN induced fibrosis.     

The Role of Cholesterol on Triterpenoid Saponin-Induced Endolysosomal Escape of a Saporin-Based Immunotoxin

Cholesterol seems to play a central role in the augmentation of saporin-based immunotoxin (IT) cytotoxicity by triterpenoid saponins. Endolysosomal escape has been proposed as one mechanism for the saponin-mediated enhancement of targeted toxins. We investigated the effects of lipid depletion followed by repletion on Saponinum album (SA)-induced endolysosomal escape of Alexa Fluor labelled saporin and the saporin-based immunotoxin OKT10-SAP, directed against CD38, in Daudi lymphoma cells. Lipid deprived cells showed reduced SA-induced endolysosomal escape at two concentrations of SA, as determined by a flow cytometric method. The repletion of membrane cholesterol by low density lipoprotein (LDL) restored SA-induced endolysosomal escape at a concentration of 5 µg/mL SA but not at 1 µg/mL SA. When LDL was used to restore the cholesterol levels in lipid deprived cells, the SA augmentation of OKT10-SAP cytotoxicity was partially restored at 1 µg/mL SA and fully restored at 5 µg/mL SA. These results suggest that different mechanisms of action might be involved for the two different concentrations of SA and that endosomal escape may not be the main mechanism for the augmentation of saporin IT cytotoxicity by SA at the sub-lytic concentration of 1 µg/mL SA.     

Nutrient budget for Saguling Reservoir,West Java,Indonesia

A preliminary nutrient budget for Saguling Reservoir is reported as a first attempt to quantify the behaviour of nutrients entering this reservoir. This work is part of a larger Indonesia-Australia collaborative research and training project, involving Padjadjaran University and Monash University, established to study nutrient dynamics in Saguling Reservoir. Saguling Reservoir, the first of a chain of three large reservoirs (Saguling, Cirata and Jatilahur), built on the Citarum River in central Java, was completed in 1985. It has already become highly polluted, particularly with domestic and industrial effluent (organic matter, nutrients, heavy metals) from the urban areas of Bandung (population 2 million). The reservoir experiences major water quality problems, including excessive growths of floating plants, toxic cyanobacterial blooms and regular fish-kills. The work reported in this paper shows that Saguling receives a very large nutrient load from the city of Bandung and because of this, is highly eutrophic. It is unlikely that the water quality of Saguling will improve until a substantial part of Bandung is sewered and adequate discharge controls are placed on the many industries in the region upstream of the reservoir.     

Urbanization Effect on Floristic and Landscape Patterns of Green Spaces

The study explored the effects of intensive urbanization on urban plant diversity and landscape pattern. An inventory of plant species in managed green spaces in the nine urban districts of Guangzhou (south China) with varied development history was conducted. The relationships among species richness, diversity and urban development were analysed by community ecology attributes, cluster analysis, growth-form differentiation and district fidelity indices, and statistical tests. The 1055 vascular species were dominated by a small number of common evergreen species, accompanied by many rare species. By species richness, tree was the dominant growth form, followed by herb and shrub. Species richness and diversity were slightly below urban-fringe secondary forests. Old and young districts offered disparate conditions for species enrichment to establish urban landscape patterns with divergent floristic and growth-form assemblages. Urban species profile and vegetation landscapes were mainly influenced by planning and management of the urban landscape and changing landscape fashion.     

Nature's Neighborhood: Urban Environmental History and Neighborhood Planning

The physical form of an urban settlement is a product of the reciprocal relationship between the humans and the ecological systems in the area which act together to create an urban landscape that changes through time. While many of the interactions between the natural world and the built environment occur at the regional level, the quality of life experienced by residents is in large part a function of environmental conditions in the neighborhood. This article explores the benefits to neighborhood planning from incorporating urban environmental history. It reviews the conceptual territory of urban environmental history and presents a framework for its application to neighborhood planning. An environmental history completed for a neighborhood is highlighted to illustrate the technique.     

Core–periphery dynamics in the Portland, Oregon, region: 1982–2006

The relative strength of positive and negative spillovers of urban development is a long-standing and contested issue in regional and development economics, and the search for spread and backwash effects of development in urban core economies goes back at least 50 years. Using data from IMPLAN and the Bureau of Economic Analysis to develop multiregional input–output models, we developed estimates of core–periphery economic interdependence (sales and purchases of goods and services and commuting of workers between the core and the periphery) of the Portland, Oregon, region for 1982 and 2006. We explored whether the changing flows of sales and purchases, spillovers and commuting between 1982 and 2006 suggested a dominance of spread effects or backwash effects. We found increased commuting between periphery and core, decreased core–periphery transactions, and smaller core-to-periphery spillovers and periphery-to-core spillovers in both goods and services. Our findings do not point to a clear dominance of spread or backwash effects. Results showing smaller core-to-periphery and periphery-to-core multipliers/spillovers suggest that spread effects related to trade in goods and services weakened between 1982 and 2006. Our findings of increased commuting are consistent with enhanced spread effects in labor markets.     

Land Use Planning and Bushfire Risk: CFA Referrals and the February 2009 Victorian Fire Area

The Victoria Planning Provisions (VPPs) include siting and design regulations incorporated into local government planning schemes to mitigate risk in areas prone to bushfires. Introduced in 1997, these provisions were previously called the Wildfire Management Overlay (WMO). Now updated and renamed the Bushfire Management Overlay (BMO), the provision's ongoing development has been informed by fire behaviour and how houses ignite. The aim of the research reported here, conducted following the catastrophic February 2009 Victorian fires, was to review dwelling losses in terms of the WMO's effectiveness. Empirical evidence compares house losses of dwellings referred to the Country Fire Authority (CFA) via the WMO, with overall house losses. The results suggest that proportionately fewer houses referred to the CFA were lost, compared with those not assessed under the WMO. It should be noted that other factors influenced the results, such as the houses assessed under the WMO being generally newer.