全文获取类型
收费全文 | 148879篇 |
免费 | 13641篇 |
国内免费 | 7297篇 |
专业分类
电工技术 | 9832篇 |
技术理论 | 16篇 |
综合类 | 12212篇 |
化学工业 | 23320篇 |
金属工艺 | 8526篇 |
机械仪表 | 9471篇 |
建筑科学 | 11262篇 |
矿业工程 | 4240篇 |
能源动力 | 4311篇 |
轻工业 | 12934篇 |
水利工程 | 2838篇 |
石油天然气 | 7873篇 |
武器工业 | 1473篇 |
无线电 | 16473篇 |
一般工业技术 | 16664篇 |
冶金工业 | 6080篇 |
原子能技术 | 1775篇 |
自动化技术 | 20517篇 |
出版年
2024年 | 275篇 |
2023年 | 2473篇 |
2022年 | 4239篇 |
2021年 | 6272篇 |
2020年 | 4890篇 |
2019年 | 3670篇 |
2018年 | 4057篇 |
2017年 | 4762篇 |
2016年 | 3901篇 |
2015年 | 5964篇 |
2014年 | 7880篇 |
2013年 | 9334篇 |
2012年 | 10794篇 |
2011年 | 11752篇 |
2010年 | 10368篇 |
2009年 | 9803篇 |
2008年 | 9766篇 |
2007年 | 9206篇 |
2006年 | 8797篇 |
2005年 | 7146篇 |
2004年 | 5071篇 |
2003年 | 4316篇 |
2002年 | 4328篇 |
2001年 | 3671篇 |
2000年 | 3227篇 |
1999年 | 2933篇 |
1998年 | 2234篇 |
1997年 | 1799篇 |
1996年 | 1625篇 |
1995年 | 1250篇 |
1994年 | 1031篇 |
1993年 | 692篇 |
1992年 | 571篇 |
1991年 | 422篇 |
1990年 | 324篇 |
1989年 | 262篇 |
1988年 | 192篇 |
1987年 | 122篇 |
1986年 | 101篇 |
1985年 | 52篇 |
1984年 | 42篇 |
1983年 | 37篇 |
1982年 | 43篇 |
1981年 | 32篇 |
1980年 | 38篇 |
1979年 | 14篇 |
1976年 | 8篇 |
1970年 | 3篇 |
1959年 | 10篇 |
1951年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 58 毫秒
1.
Jingwei Shi Xujun Song Benno Traub Michael Luxenhofer Marko Kornmann 《International journal of molecular sciences》2021,22(6)
Interleukin (IL)-4 and IL-13 are known as pleiotropic Th2 cytokines with a wide range of biological properties and functions especially in immune responses. In addition, increasing activities have also been determined in oncogenesis and tumor progression of several malignancies. It is now generally accepted that IL-4 and IL-13 can exert effects on epithelial tumor cells through corresponding receptors. Type II IL-4 receptor (IL-4Rα/IL-13Rα1), predominantly expressed in non-hematopoietic cells, is identified to be the main target for both IL-4 and IL-13 in tumors. Moreover, IL-13 can also signal by binding to the IL-13Rα2 receptor. Structural similarity due to the use of the same receptor complex generated in response to IL-4/IL-13 results in overlapping but also distinct signaling pathways and functions. The aim of this review was to summarize knowledge about IL-4 and IL-13 and their receptors in pancreatic cancer in order understand the implication of IL-4 and IL-13 and their receptors for pancreatic tumorigenesis and progression and for developing possible new diagnostic and therapeutic targets. 相似文献
2.
A new aqueous slurry-based laminated object manufacturing process for porous ceramics is proposed: firstly, an organic mesh sheet is pre-paved as a pore-forming template before slurry layer scraping; secondly, the 2D pattern is built with laser outline cutting of the dried mesh–ceramic composite layer; finally, the pore structure is formed after degreasing and sintering. Alumina parts with porosities of 51.5 %, round hole diameters of 80 ± 5 μm were fabricated using 70 wt. % solid content slurry and 100 mesh nylon net. Using an organic mesh as the framework and template not only reduces the risk of damage of the green body but also ensures the regularity, uniformity and connectivity of the micron scaled pore network. The layer-by-layer drying method avoids the delamination phenomenon and improves the paving density. The new method can realize the flexible design of the pore structure by using various organic mesh templates. 相似文献
3.
我公司1#生产线的窑头使用布袋收尘器,型号:HMMC391-4×4,处理风量:1 350 000 m3/h,过滤风速<0.9 m/min,收尘器风室4 排×4 列。投入使用3个月后停机检查,发现第一排4 个风室的滤袋较多底部被磨穿,主要集中在灰斗四周的前3 环区域,前两排风室其他位置的滤袋也较多出现异常磨损,但后
两排风室的滤袋却完好无损。 相似文献
4.
利用蒸馏分离—气相色谱法技术,建立了同时测定煤焦油中苊、氧芴和芴的分析方法。通过对色谱条件的优化,以甲苯为溶剂,正十二烷为内标物,将煤焦油馏分采用DB-5毛细管柱,对煤焦油中苊、氧芴和芴定量分析。分析结果表明:3种主要成分线性关系良好,相关系数均大于0.9995,加标回收率为95.4%~102.4%,相对标准偏差为2.89%~7.14%。该方法分离效果好,检测结果准确、可靠。 相似文献
5.
6.
Shimei Fu Song Xue Jun Chen Shuai Shang Hui Xiao Yu Zang Xuexi Tang 《International journal of molecular sciences》2021,22(4)
The effects of ultraviolet (UV) radiation, particularly UV-B on algae, have become an important issue as human-caused depletion of the protecting ozone layer has been reported. In this study, the effects of different short-term UV-B radiation on the growth, physiology, and metabolism of Porphyra haitanensis were examined. The growth of P. haitanensis decreased, and the bleaching phenomenon occurred in the thalli. The contents of total amino acids, soluble sugar, total protein, and mycosporine-like amino acids (MAAs) increased under different UV-B radiation intensities. The metabolic profiles of P. haitanensis differed between the control and UV-B radiation-treated groups. Most of the differential metabolites in P. haitanensis were significantly upregulated under UV-B exposure. Short-term enhanced UV-B irradiation significantly affected amino acid metabolism, carbohydrate metabolism, glutathione metabolism, and phenylpropane biosynthesis. The contents of phenylalanine, tyrosine, threonine, and serine were increased, suggesting that amino acid metabolism can promote the synthesis of UV-absorbing substances (such as phenols and MAAs) by providing precursor substances. The contents of sucrose, D-glucose-6-phosphate, and beta-D-fructose-6-phosphate were increased, suggesting that carbohydrate metabolism contributes to maintain energy supply for metabolic activity in response to UV-B exposure. Meanwhile, dehydroascorbic acid (DHA) was also significantly upregulated, denoting effective activation of the antioxidant system. To some extent, these results provide metabolic insights into the adaptive response mechanism of P. haitanensis to short-term enhanced UV-B radiation. 相似文献
7.
8.
Suk-Young Song Soonil Pyo Sungchul Choi Hee Sang Oh Jung Hwa Seo Ji Hea Yu Ahreum Baek Yoon-Kyum Shin Hoo Young Lee Ja Young Choi Sung-Rae Cho 《International journal of molecular sciences》2021,22(7)
Hypoxic–ischemic encephalopathy (HIE) is a devastating neonatal brain condition caused by lack of oxygen and limited blood flow. Environmental enrichment (EE) is a classic paradigm with a complex stimulation of physical, cognitive, and social components. EE can exert neuroplasticity and neuroprotective effects in immature brains. However, the exact mechanism of EE on the chronic condition of HIE remains unclear. HIE was induced by a permanent ligation of the right carotid artery, followed by an 8% O2 hypoxic condition for 1 h. At 6 weeks of age, HIE mice were randomly assigned to either standard cages or EE cages. In the behavioral assessments, EE mice showed significantly improved motor performances in rotarod tests, ladder walking tests, and hanging wire tests, compared with HIE control mice. EE mice also significantly enhanced cognitive performances in Y-maze tests. Particularly, EE mice showed a significant increase in Cav 2.1 (P/Q type) and presynaptic proteins by molecular assessments, and a significant increase of Cav 2.1 in histological assessments of the cerebral cortex and hippocampus. These results indicate that EE can upregulate the expression of the Cav 2.1 channel and presynaptic proteins related to the synaptic vesicle cycle and neurotransmitter release, which may be responsible for motor and cognitive improvements in HIE. 相似文献
9.
Min Ma Wan-Chang Sun Ya-Ru Dong Ya-Gang Zhang Yu-Wan Liu Sha-Sha Tian Yan Xiao 《工业材料与腐蚀》2021,72(5):912-924
Diamond-like carbon (DLC) possesses brilliant and excellent properties, including excellent corrosion resistance as well as outstanding wear resistance. Ni and B co-doped DLC films were deposited on AZ91D magnesium alloy by electrodeposition under mild conditions (300 V and 25°C). Uniform and dense morphology of co-doped DLC films were observed, and Ni and B were uniformly incorporated into the carbon-based films. Among all the electrodeposits, the appearance of D and G peaks near 1330 and 1570 cm−1 revealed that the as-deposited films were typical DLC films. As the addition of Ni was increased to 0.05 g, the highest microindentation hardness, the lowest friction coefficient, and wear loss were achieved to be 164.5 HV, 0.3, and 0.6 × 10−5 kg/m, respectively. The amorphous carbon films fabricated at 0.05 g Ni had the lowest corrosion current density and the most positive corrosion potential, which was mainly due to the small and dense granular structure effectively hindering the penetration of corrosion media. 相似文献
10.
The construction and examination of meso-structural finite element models of a Chemical-Vapor-Infiltrated (CVI) C/SiC composite is carried out based on X-ray microtomography digital images (IB-FEM). The accurate meso-structural features of the C/SiC composites, which are consisted of carbon fiber tows and CVI-SiC matrix, in particular the cavity defects, are reconstructed. With the IB-FEM, the damage evolution and fracture behaviors of the C/SiC composite are investigated. At the same time, an in situ tensile test is applied to the C/SiC composite under a CT real-time quantitative imaging system, aiming to investigate the damage and failure features of the material as well as to verify the IB-FEM. The IB-FEM results indicate that material damage initially occur at the defects, followed by propagating toward the fiber-tow/SiC-matrix interfaces, ultimately, combined into macro-cracks, which is in good agreement with the in situ CT experiment results. 相似文献