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排序方式: 共有107条查询结果,搜索用时 47 毫秒
1.
Monika Warat Ewelina Szliszka Ilona Korzonek-Szlacheta Wojciech Król Zenon P. Czuba 《International journal of molecular sciences》2014,15(7):11510-11522
Expression level of Tumor Necrosis Factor—related apoptosis—inducing ligand (TRAIL) receptors is one of the most important factors of TRAIL-mediated apoptosis in cancer cells. We here report for the first time data concerning TRAIL-R1 and TRAIL-R2 receptor expression on RAW264.7 macrophages. Three substances belonging to flavones: chrysin, apigenin and acacetin which differ from their substituents at the 4'' position in the phenyl ring were used in assays because of the variety of biological activities (e.g., anticancer activity) of the polyphenol compounds. The expression of TRAIL-R1 and TRAIL-R2 death receptors on non-stimulated and LPS (lipopolysaccharide)-stimulated macrophages was determined using flow cytometry. We demonstrate that RAW264.7 macrophages exhibit TRAIL-R1 surface expression and that the tested compounds: chrysin, apigenin and acacetin can inhibit TRAIL-R1 death receptor expression level on macrophages. 相似文献
2.
Thomas M. Klaptke Tomasz G. Witkowski Zenon Wilk Justyna Hadzik 《Propellants, Explosives, Pyrotechnics》2016,41(1):92-97
A comprehensive investigation to determine the initiation power of detonators containing as a base charge the novel explosives: dihydroxylammonium 5,5′‐bis(tetrazolate‐1N‐oxide) – TKX‐50, dihydroxylammonium 5,5′‐bis(3‐nitro‐1,2,4‐triazolate‐1N‐oxide) – MAD‐X1, pentaerythritol tetranitrocarbamate – PETNC and 3,3′‐diamino‐4,4′‐azoxyfurazan – DAAF in comparison with RDX, HMX and PETN was undertaken. In order to estimate the initiation power of the detonators, the underwater initiating capability test was used. The total energy as a sum of the primary shock wave energy and the bubble gas energy was determined for each of these explosives, by measuring the overpressure of the shock waves generated in water. Moreover, the complete synthesis for novel explosives is presented. The thermal behavior of the explosives was investigated using DSC (differential scanning calorimetry). The gas phase absolute molar enthalpies at 298 K and 105 Pa were calculated theoretically using the modified complete basis set method (CBS‐4M; M referring to the use of minimal population localization) with the Gaussian 09 software. Gas phase standard molar enthalpies of formation (ΔHf°(g)) at 298 K were computed using the atomization energy method. Standard molar enthalpies of formation (▵H(s)°) were calculated using ΔHf°(g) and the standard molar enthalpies of sublimation by applying Trouton’s rule. The Chapman‐Jouguet (CJ) characteristics based on calculated ▵H(s)° values were computed using the EXPLO5 V6.01 thermochemical computer code. For the calculations the theoretical maximum densities and densities obtained during the experiments presented in this work were used. 相似文献
3.
Inclusion of flaxseed in turkey diets decreases the n‐6/n‐3 PUFA ratio and increases the proportion of biologically active EPA and DHA without affecting meat quality 下载免费PDF全文
4.
Zenon Sarbak 《Catalysis Today》2001,65(2-4):293-299
In the search for the active catalysts of hydrodesulfurization reaction, an attempt was made to use zeolites as supports. A series of NaLaX, Mo/NaLaX and NiMo/NaLaX as well as NaLaY, Mo/NaLaY and NiMo/NaLaY catalysts was prepared and their performance in this reaction was studied. It was shown that crystalline structure of the lanthana forms of the above zeolites only little collapsed after ion-exchange and impregnation with active Mo and NiMo components. The NiMo catalysts supported on the zeolites studied were found active in thiophene hydrodesulfurization. The catalysts with lanthana after the first step of ion exchange were the most active. 相似文献
5.
Istvan Páczelt Zenon Mróz 《International journal for numerical methods in engineering》2010,81(6):728-760
A transient wear process on frictional interface of two thermo‐elastic bodies in a relative steady sliding motion induces shape evolution of contact interface and tends to a steady state for which the wear process occurs at fixed contact stress and strain distribution. The temperature field generated by frictional and wear dissipation on the contact surface is assumed to reach a steady state. This state is assumed to correspond to minimum of the wear dissipation power and the temperature field corresponds to maximum of the heat entropy production. The stationarity conditions of the response functionals provide the contact pressure distribution and the corresponding temperature field. The present approach extends the authors previous analyses of optimal or steady‐state contact shapes by accounting for coupled wear and thermal distortion effects. The wear rule is assumed as a non‐linear relation of wear rate to shear stress and relative sliding velocity. The analysis of disk and drum brakes is presented with account for thermal distortion effect. It is shown that the contact shape in a steady thermo‐elastic state essentially differs from that specified for mechanical loading with neglect of thermal effects. The thermal instability regimes are not considered in the paper. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
6.
Zenon Foltynowicz Wojciech Kozak Ryszard Fiedorow 《Packaging Technology and Science》2002,15(2):75-81
Temperature‐programmed reduction (TPR) measurements were performed for iron oxalates, iron(III) hydroxide (both pure and with additives) and iron(II, III) oxide. On the ground of TPR curves, reduction temperatures of the iron‐containing parent substances were chosen followed by oxygen uptake determination. Comparison of oxygen uptakes points to the use of Fe(OH)3 and Fe3O4 as more advantageous than that of iron oxalates. Co‐precipitation from a mixed solution of iron and manganese salts results in a product which is more resistant to particle agglomeration at elevated temperatures than that obtained byprecipitation from solution of iron salt alone. Copyright © 2002 JohnWiley & Sons, Ltd. 相似文献
7.
8.
Blaszczyk-Thurin Magdalena; Murali Ramachandran; Westerink M.A.Julie; Steplewski Zenon; Co Man Sung; Kieber-Emmons Thomas 《Protein engineering, design & selection : PEDS》1996,9(5):447-459
The murine monoclonal antibody BR55-2 is directed against thetumor-associated antigen Lewis Y oligosaccharide. The LewisY core antigen is a difucosylated structure consisting of fourhexose units. Analysis of binding profiles of lactoseries isomericstructures by BR552 suggest that the binding epitopeincludes the OH-4 and OH-3 groups of the ß-D-galactoseunit, the 6-CH3 groups of the two fucose units and the N-acetylgroup of the subterminal ß-D-N-acetylglucosamine (ßDGlcNAc).To elucidate the molecular recognition properties of BR552for the Y antigen, BR552 was cloned, sequenced and itsthree-dimensional structure was examined by molecular modeling.The crystal structure of BR96, another anti-Lewis Y antibody,solved in complex with a nonoate methyl ester Lewis Y tetrasaccharide,and the lectin IV protein in complex with a Lewis b tetrasaccharidecore were used as a guide to probe the molecular basis for BR552antigen recognition and specificity. Our modeling study showsthat BR552 shares similar recognition features for thedifucosylated type 2 lactoseries Lewis Y structure observedin the BR96-sugar complex. We observe that a major source ofspecificity for the Lewis Y structure by anti-Y antibodies emanatesfrom interaction with the ß-D-N-acetylglucosamineresidue and the nature of the structures extended at the reducingsite of the fucosylated lactosoamine. 相似文献
9.
A non-local stress condition for crack initiation and propagation is proposed and applied to several particular cases, such as plate with wedge-shaped notch, elliptical hole and hyperbolic notch. Brittle failure initiation for notched elements under complex loading (Modes I and II) is studied in detail. A value of critical load and crack orientation is predicted from the non-local condition, which is applicable to both regular and singular stress concentrations. 相似文献
10.
Charles Musca Jaroslaw Antoszewski John Dell Lorenzo Faraone Józef Piotrowski Zenon Nowak 《Journal of Electronic Materials》1998,27(6):740-746
This paper describes a new multi-heterojunction n
+pp photovoltaic infrared photodetector. The device has been developed specifically for operation at temperatures of 200–300K
in the long wavelength (8–14 μm) range of the infrared spectrum. The new structure solves the perennial problems of poor quantum
efficiency and low dynamic resistance found in conventional long wavelength infrared photovoltaic detectors when operated
near room temperature. Computer simulations show that devices with properly optimized multiple heterojunctions are capable
of achieving the performance limits imposed by the statistical nature of thermal generation-recombination processes. In order
to demonstrate the technology, multiple heterojunction devices have been fabricated on epilayers grown by isothermal vapor
phase epitaxy of HgCdTe and in situ As p-type doping. The detector structures were formed using a combination of conventional dry etching, angled ion milling,
and angled thermal evaporation for contact metal deposition. These multi-junction n
+pp HgCdTe heterostructure devices exhibit performances which make them useful for many applications. D* of optically immersed
multiple heterostructure photovoltaic detectors exceeding 108cmHz1/2/W were measured at λ=10.6 μm and T=300K. 相似文献