Improved aqueous solubility,bioaccessibility and cellular uptake of quercetin following pH-driven encapsulation in whey protein isolate

The purpose of this study was to increase the water solubility and potential bioavailability of quercetin by encapsulation in whey protein isolate (WPI) based on a green, efficient pH-driven method. According to the results, the water solubility of quercetin increased by 346.9: times after loading into WPI nanoparticles. When the initial quercetin concentration was 0.25 mg mL⁻¹ and WPI was 2% w/v, the encapsulation efficiency reached 94.1%, the Z-average diameter was 36.63 nm, and the zeta potential was −36.4 mV at pH 7.0. The fluorescence spectroscopy assay suggested the molecular complexation of quercetin and WPI at pH 12.0. X-ray diffraction assay indicated the enclosure of amorphous quercetin in WPI. Correspondingly, the bioaccessibility increased from 2.76% to 31.23% and the Caco-2 cell monolayer uptake increased from 0% to 2.12% after nanoencapsulation. This work confirmed that the pH-driven method is an effective approach to prepare WPI–quercetin nanocapsules to improve physical and potentially biological properties of quercetin.     

带键槽梁底筋锚入式预制梁柱连接塑性铰长度研究

针对混凝土构件在反复荷载作用下的受力特点,提出了拉-压综合塑性铰长度概念;通过低周反复荷载试验,研究了带键槽梁底筋锚入式预制梁柱连接的塑性铰特点,并得出了拉-压综合塑性铰长度的试验结果;以Panagiotakos模型为基础,提出了考虑预制形式、混凝土局部横向约束和配筋率影响的修正塑性铰长度模型。结果表明：拉-压综合塑性铰长度可综合反映反复荷载作用下塑性铰的损伤情况;带键槽梁底筋锚入式预制梁柱连接塑性铰形态与现浇对比试件略有差别;修正的塑性铰长度模型可以较好地预测该类梁柱连接拉-压综合塑性铰长度。     

An approach to technical risk assessment

This paper describes a framework for assessment of the risk that a proposed machine or system, such as an aircraft or computer, will not operate to its required performance specifications when it is developed. The method is based upon decomposition of the system under assessment into a hierarchy of functionally or structurally defined assessment areas. Within each area, technical risks, and methods of assessing these risks, are identified. The framework provides a systematic structure for selecting assessment methods and integrating results of the use of selected methods into a coherent overall assessment of the system.     

南京火车站钢屋盖斜拉索张拉的优化和调整

南京火车站主站房预应力钢屋盖采用桅杆斜拉索悬挂钢结构型式。本文通过拉索张拉分析,掌握结构特点和拉索索力相互影响程度,优化张拉方案,简便施工,并根据工程实际需要,调整张拉方案。     

江宁体育场桅杆斜拉索高空施工平台设计与施工

以南京江宁体育场工程为背景,根据屋盖桅杆斜拉索特点及其安装方法进行了施工平台设计方案的选型,综合考虑施工现场状况、机械设备起重能力、受荷特点及施工平台结构的安全性与经济性等因素,对四种方案进行了对比评析,最终确定在桅杆顶近75m高的锚箱处搭设高空斜撑式型钢悬挑施工平台。施工平台主要承受移动集中荷载作用,内力计算采用了影响线分析方法,得出内力包络图用于杆件截面设计,确保了设计的可靠性。实践证明该方案可行。     

不对称混合连接的抗震性能模拟及关键参数研究

不对称混合连接属于后张有阻尼干连接延性节点,采用有限元分析程序DRAIN_2DX研究梁柱节点在低周反复荷载下的抗震性能.有限元分析结果表明:滞回曲线明显呈不对称形状,正向加载时的滞回曲线较为饱满,耗能较好,反向加载时的滞回曲线所包围的面积较小,耗能较差;滞回曲线大体呈反S形,随着位移的增加逐渐向弓形过渡;截面初始预压应...     

High‐temperature low‐cycle fatigue behaviour of a cast Al–12Si–CuNiMg alloy

The low‐cycle fatigue behaviour of a cast Al–12Si–CuNiMg alloy, with a high content of Si, is investigated at 200, 350 and 400 °C. The fatigue test results show that the alloy exhibits symmetrical hysteresis loops, moderate cyclic softening and higher fatigue resistance at higher temperature. The fracture surface analysis reveals that more tear ridges are formed at higher temperature, which strongly affect the fatigue resistance. Furthermore, evaluation of the material fatigue resistance using an energy‐based Halford–Marrow model indicates that the material's ability to absorb and dissipate plastic strain energy is enhanced as temperature increases.     

Fault Detection for Nonlinear Networked Control Systems with Markov Data Transmission Pattern

This paper is concerned with the fault-detection problem of nonlinear multiple channels data transmission networked control systems (NCSs). Two irrelevant Markov chains are introduced to describe the data transmission characterization of nonlinear delayed NCSs with data loss in both from sensors to controller and from controller to actuators, and a nonlinear Markovian jump system model is established. Based on this novel model, employing a mode-dependent fault-detection filter as residual generator, a fault-detection filter design of nonlinear NCSs is formulated as a nonlinear H _∞-filtering problem. Then an appropriate Lyapunov functional is chosen to derive the sufficient condition which satisfies the stochastic stability and prescribes the H _∞ attenuation level simultaneously. Especially, the desired mode-dependent fault-detection filters are constructed in terms of certain linear matrix inequalities (LMIs), and explicit parameters are characterized if these LMIs are feasible. The effectiveness of the proposed method is demonstrated by a simulation example.