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Janis Fricke Dr. Alexander Sherwood Dr. Robert Kargbo Dr. Andrew Orry Felix Blei Dr. Andreas Naschberger Dr. Bernhard Rupp Prof. Dr. Dirk Hoffmeister 《Chembiochem : a European journal of chemical biology》2019,20(22):2824-2829
Psilocybin and its direct precursor baeocystin are indole alkaloids of psychotropic Psilocybe mushrooms. The pharmaceutical interest in psilocybin as a treatment option against depression and anxiety is currently being investigated in advanced clinical trials. Here, we report a biocatalytic route to synthesize 6-methylated psilocybin and baeocystin from 4-hydroxy-6-methyl-l -tryptophan, which was decarboxylated and phosphorylated by the Psilocybe cubensis biosynthesis enzymes PsiD and PsiK. N-Methylation was catalyzed by PsiM. We further present an in silico structural model of PsiM that revealed a well-conserved SAM-binding core along with peripheral nonconserved elements that likely govern substrate preferences. 相似文献
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