Xanthohumol for Human Malignancies: Chemistry,Pharmacokinetics and Molecular Targets

Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure–activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers.     

一次性使用医用手套标准解读

一次性医用手套是能够防止人们交叉感染的常用防护用品。随着新冠肺炎疫情在全球范围的迅速蔓延,疫情防控一线以及广大普通民众对一次性医用手套的需求与日俱增,其标准也受到广泛关注。本文对中国国家标准涉及一次性使用医用手套的4项产品标准进行了解读,并分析它们与国外同种产品标准间的对应关系以及重点指标的差异。     

Annual and regional variations of aflatoxin B1 levels seen in grains and feed coming from Croatian dairy farms over a 5-year period

The aim of the study was to investigate annual and regional differences in the level of aflatoxin B₁ (AFB₁) in grains and dairy cattle feed. Maize (n = 972), wheat (n = 201), barley (n = 147), oat (n = 136), grain mixtures (n = 168), and dairy cattle feed (n = 325) were sampled from 2009 to 2013 on different farms and in different farm factories situated in four Croatian regions. The samples were analysed for AFB₁ using the validated ELISA immunoassay. AFB₁ was determined in 16.4% of all investigated samples, among which maize was proven to be the most contaminated, with 21.7% of the samples recovered during 2013 harbouring AFB₁ in concentrations over the permissible ones. Levels higher than permitted were observed in 17.9% and 12.3% of grain mixtures and dairy cattle feed, respectively, whereas concentrations of AFB₁ determined in other crops throughout the investigated period met the stipulated requirements. The results revealed the AFB₁ occurrence to be significantly (p < 0.05) dependent on the cultivation region, with the highest levels generally found in maize harvested in 2013 and consequently in grain mixtures and cattle feed that can most likely be associated with climatic conditions as the most critical factor for mould formation, and thus also AFB₁ production.     

高瓦斯突出矿井底抽巷一巷多用技术研究与实践

胡底煤业为高瓦斯高突出高矿压的三高矿井。对高瓦斯高突出的治理，该矿采用“地面网络预抽、区域模块降量、底抽穿层保掘、高位顺层保采”的四级模式，施工底抽巷，实现“底抽穿层消突、区域模块降量、异巷探测增效、多巷通风治患、循环排矸减压”等“一巷多用”。该4种方法已在1303（上）、1305（上）工作面应用并推广，取得了良好的效果，大大提高了掘进效率且满足抽放、探放水、通风需要；回填矸石初步设计现已经完善，待下一步掘进将实现填矸作用。     

云冈矿采空区自然发火综合治理技术实践

针对云冈矿12#煤层8820、8822采空区出现CO泄漏事件,采用粉煤灰填充,构筑木板墙充填粉煤灰,配以墙体周边注马丽散堵漏;采用灌浆泵进行地面黄土灌浆,实施采空区灭火。通过对采空区自然发火进行综合治理,取得了良好效果,消除了自然发火隐患。     

陈四楼煤矿“123456双重预防体系”的建设与应用

针对煤矿“双重预防体系”如何落地生根问题，结合陈四楼煤矿在风险分级管控和隐患排查治理方面的实用方法和“双重预防体系”的建设经验，深入研究了“双重预防体系”的相关标准、风险隐患事故之间的关系及其各自的产生和发展机理、安全风险的有关辨识评估方法、事故隐患的排查和治理方法，分析了传统安全管理模式与“双重预防体系”的新型安全管理模式的差别，总结出了“123456双重预防体系”这个囊括了事前安全风险辨识、事中隐患排查治理、事后安全现状评估的创新成果，实现了“事前、事中、事后”的全过程控制，对夯实煤矿安全管理根基、促进矿井平稳有序发展发挥着越来越重要的作用，为煤炭行业“双重预防体系”的落地生根提供了借鉴和参考。     

Smart firefighting construction in China: Status,problems, and reflections

“Smart firefighting” construction as a part of the “smart city” has been a concern of the public security and fire agencies at all levels. In this study, the status, problems, and reflections of “smart firefighting” construction in China are discussed. A recent survey indicates that China has launched its smart firefighting construction and initially created a new perspective on its regional smart firefighting work based on three main aspects: intelligent disaster perception by Internet of Things (IoT) construction, intelligent disaster prevention by big data construction, and intelligent disaster disposal by emergency rescue platform construction. However, the current smart firefighting construction in China still has some prominent problems such as the data interconnectivity and normalized management of various platforms, the extensibility of smart firefighting platforms, and the intelligent level of smart firefighting researches, which need to be solved urgently. Therefore, we argue that smart firefighting construction in China should establish data interconnectivity, industrial normalized management, 2D/3D geographic information interaction and extension, high-integration fire protection theory, and many other aspects in the near future and truly realize firefighting visualization and efficient data applications for 4D time space. This study could provide valuable reference for smart firefighting and smart city construction.     

基于SVM的煤与瓦斯突出预测模型及应用

为有效预测矿井内煤与瓦斯突出的危险程度,对其影响因素做了分析与探讨,分别构建了基于粒子群优化算法以及遗传算法支持向量机的煤与瓦斯突出预测模型,并且通过实例对两种模型预测的准确性进行了验证。分别利用单项以及综合指标、BP神经网络以及PSO-SVM模型、GA-SVM模型,对寺河煤矿二号井的突出区域进行预测比较。结果表明,PSO-SVM的预测模型不仅可以在小样本数据中预测出煤与瓦斯突出程度的大小,而且综合预测结果更加精确,其在解决矿井内煤与瓦斯突出的小样本数据中显示出更加强大、通用的性能。     

煤矿冲击矿压预测和防治技术浅析

结合镇城底煤矿22605工作面的地质情况和矿压情况,提出了煤炭生产中冲击矿压的预测和防治措施。通过对22605工作面的地质情况和监测数据分析处理并探究了该工作面矿压显现规律,为其设计了一套适合本工作面的冲击矿压监测和防治体系。防治体系有预防和临时解危双重防治措施,从这两方面考虑可以做到全面防治冲击矿压。该体系可以实现矿井的安全生产,保证工作人员的安全。另通过分析冲击矿压发生的基本原理和监测到的数据,建立煤矿冲击矿压防治体系,能够及时有效地将蕴含在煤体中的冲击矿压释放和消除,达到安全生产的目的。