一种新型地雷战斗部的数值模拟研究

针对地雷的毁伤目标和特性,提出一种新颖的多棱柱状药型罩结构,其可看作由八个楔形罩对称排列相邻连接而成。应用非线性有限元软件完成了爆炸载荷下多棱柱状药型罩形成射流过程的数值模拟,结果表明新型药型罩结构能够实现预期设想,形成一股汇聚射流。研究结果为地雷战斗部研究提供了一种新的选择。     

Inhibitory Monoclonal Antibodies and Their Recombinant Derivatives Targeting Surface-Exposed Carbonic Anhydrase XII on Cancer Cells

Monoclonal and recombinant antibodies are widely used for the diagnostics and therapy of cancer. They are generated to interact with cell surface proteins which are usually involved in the development and progression of cancer. Carbonic anhydrase XII (CA XII) contributes to the survival of tumors under hypoxic conditions thus is considered a candidate target for antibody-based therapy. In this study, we have generated a novel collection of monoclonal antibodies (MAbs) against the recombinant extracellular domain of CA XII produced in HEK-293 cells. Eighteen out of 24 MAbs were reactive with cellular CA XII on the surface of live kidney and lung cancer cells as determined by flow cytometry. One MAb 14D6 also inhibited the enzymatic activity of recombinant CA XII as measured by the stopped-flow assay. MAb 14D6 showed the migrastatic effect on human lung carcinoma A549 and renal carcinoma A498 cell lines in a ‘wound healing’ assay. It did not reduce the growth of multicellular lung and renal cancer spheroids but reduced the cell viability by the ATP Bioluminescence assay. Epitope mapping revealed the surface-exposed amino acid sequence (35-FGPDGENS-42) close to the catalytic center of CA XII recognized by the MAb 14D6. The variable regions of the heavy and light chains of MAb 14D6 were sequenced and their complementarity-determining regions were defined. The obtained variable sequences were used to generate recombinant antibodies in two formats: single-chain fragment variable (scFv) expressed in E. coli and scFv fused to human IgG1 Fc fragment (scFv-Fc) expressed in Chinese Hamster Ovary (CHO) cells. Both recombinant antibodies maintained the same specificity for CA XII as the parental MAb 14D6. The novel antibodies may represent promising tools for CA XII-related cancer research and immunotherapy.     

地地战术导弹集束战斗部抛撒均匀性判定方法

简述了地地战术导弹集束战斗部抛撒均匀性判定问题 .对一种类型的集束战斗部的抛撒均匀性判定方法进行了分析 .结合实际工作运用 ,提出了注意事项 ,为其他类似的集束战斗部抛撒均匀性判定提供一种借鉴     

定向探测引信技术分析

从提高引信与战斗部配合效率出发 ,根据定向战斗部的战术技术性能 ,介绍了一种能够识别弹体周围 4个方向目标的定向探测引信 .分析了定向探测器的工作原理和目标方位识别的关键技术 ,并对探测天线的设计做了详细的分析和计算 .     

钨合金圆筒爆破试验破片分布的统计分析

采用圆筒爆破试验方法研究了易碎型钨合金的破片分布特征,并与93W合金的结果进行了对比.对破片的数量和质量分布特征进行了统计分析,发现易碎型钨合金的破片率明显高于93W合金,而且破片的均匀性也明显好于93W合金,但易碎钨合金的破片回收率低于93W合金,而且受装药量的影响较大.     

Estimating and eliminating redundant data transfers over the web: a fragment based approach

Redundant data transfers over the Web, can be mainly attributed to the repeated transfers of unchanged data. Web caches and Web proxies are some of the solutions that have been proposed, to deal with the issue of redundant data transfers. In this paper we focus on the efficient estimation and reduction of redundant data transfers over the Web. We first prove that a vast amount of redundant data is transferred in Web pages that are considered to carry fresh data. We show this by following an approach based on Web page fragmentation and manipulation. Web pages are broken down to fragments, based on specific criteria. We then deal with these fragments as independent constructors of the Web page and study their change patterns independently and in the context of the whole Web page. After the fragmentation process, we propose solutions for dealing with redundant data transfers. This paper has been based on our previous work on ‘Web Components’ but also on related work by other researchers. It utilises a proxy based, client/server architecture, and imposes changes to the algorithms executed on the Proxy server and on clients. We show that our proposed solution can considerably reduce the amount of redundant data transferred on the Web. Copyright © 2004 John Wiley & Sons, Ltd.     

一种简便的评定引战配合效率方法

在导弹近炸引信起爆延时具有随机性基础上，本文建立了一种用延时及其数学特征表示的评定引战配合效率的简便方法，并对有关应用问题进行了讨论。     

碎丝埋弧焊在大型立式储罐中的应用

大型储罐底板焊接及变形控制是保证储罐整体施工质量的关键环节,采用碎丝填充的焊接方法可以防止变形,同时可以有效地避免应力集中,提高施工质量。文章介绍了碎丝埋弧焊的原理、工艺参数和焊接方法。实践证明,填充碎丝不仅是一种减小底板焊接变形的手段,同时可以充分利用焊接热能,节约焊接时间和焊剂用量,经济效益好,是一种值得推广的技术。     

空爆毁伤地面机动目标扫描准则研究

文中主要针对多爆炸成型弹丸空爆战斗部,在分析区域识别和占空比识别两种不同扫描准则的基础上,应用蒙特卡洛方法计算了战斗部对目标的毁伤概率.通过仿真计算结果对比分析,获得了不同扫描准则对毁伤概率的影响,结果可为多爆炸成型弹丸空爆战斗部设计和选择使用扫描准则提供参考依据.     

破片式战斗部优化设计技术研究

侧重研究了破片式战斗部装药外形的优化设计技术。提出了装药外形与破片飞散特性（如破片飞散角，分布带宽等）之间的数学描述；建立了圆弧和对数螺线装药外形母线与战斗部其他设计参数间的数学模型。在假定约束条件下，优化设计了破片了聚焦式战斗部的结构参数；静爆试验结果表明，破片分布与理论计算吻合较好。