不同类型运动地坪的临界跌落高度性能对比研究

设有活动器材的运动场地通常要求依据安全下落高度来设计活动器材的安装高度。临界跌落高度与地面材料的硬度、缓冲度有极大关系。目前,运动地面铺设材料普遍采用运动地坪代替传统水泥地面,运动地坪具有一定的缓冲性,有利于防止跌落造成损伤。运动地坪包含全塑型运动地坪、混合型运动地坪、现浇型运动地坪、预制型运动地坪、人造草运动地坪等。本文通过不同的下落高度试验,以拟合曲线方式得到临界跌落高度,以此对不同类型的运动地坪的临界跌落高度性能进行对比研究。     

Drusenoid Pigment Epithelial Detachment: Genetic and Clinical Characteristics

Few studies report drusenoid pigment epithelial detachment (DPED) in Asians. In this multicenter study, we report the clinical and genetic characteristics of 76 patients with DPED, and, for comparison, 861 patients with exudative age-related macular degeneration (AMD) were included. On the initial presentation, the mean best-corrected visual acuity was 0.087 ± 0.17 (logMAR unit), and mean DPED height and width were 210 ± 132 and 1633 ± 1114 µm, respectively. Fifty-one (67%) patients showed macular neovascularization in the contralateral eye. The risk allele frequency of both ARMS2 A69S and CFH I62V was significantly higher in DPED than in typical AMD and polypoidal choroidal vasculopathy (PCV) (ARMS2 A69S risk allele frequency: DPED 77% vs. typical AMD 66% vs. PCV 57%, CFH I62V risk allele frequency: DPED 87% vs. typical AMD 73% vs. PCV 73%), although the risk allele frequency of both genes was similar between the DPED group and retinal angiomatous proliferation (RAP) group (ARMS2 A69S: p = 0.32, CFH I62V, p = 0.11). The prevalence of reticular pseudodrusen (RPD) was highest in RAP (60%), followed by DPED (22%), typical AMD (20%), and PCV (2%). Although the prevalence of RPD differs between DPED and RAP, these entities share a similar genetic background in terms of ARMS2 and CFH genes.     

CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway

Age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, is a degenerative disease of the macula, where retinal pigment epithelium (RPE) cells are damaged in the early stages of the disease, and chronic inflammatory processes may be involved. Besides aging and lifestyle factors as drivers of AMD, a strong genetic association to AMD is found in genes of the complement system, with a single polymorphism in the complement factor H gene (CFH), accounting for the majority of AMD risk. However, the exact mechanism of CFH dysregulation confers such a great risk for AMD and its role in RPE cell homeostasis is unclear. To explore the role of endogenous CFH locally in RPE cells, we silenced CFH in human hTERT-RPE1 cells. We demonstrate that endogenously expressed CFH in RPE cells modulates inflammatory cytokine production and complement regulation, independent of external complement sources, or stressors. We show that loss of the factor H protein (FH) results in increased levels of inflammatory mediators (e.g., IL-6, IL-8, GM-CSF) and altered levels of complement proteins (e.g., C3, CFB upregulation, and C5 downregulation) that are known to play a role in AMD. Moreover, our results identify the NF-κB pathway as the major pathway involved in regulating these inflammatory and complement factors. Our findings suggest that in RPE cells, FH and the NF-κB pathway work in synergy to maintain inflammatory and complement balance, and in case either one of them is dysregulated, the RPE microenvironment changes towards a proinflammatory AMD-like phenotype.     

基于混沌跳频的电力线交织编码技术

可靠性是制约低压电力线载波通信广泛应用的一个重要因素。作为公用网络,低压配电网通信的安全性也日益受到关注。从提高通信可靠性和安全性出发,论述了正交频分复用（OFDM）技术和混沌跳频（CFH）技术在电力线通信上应用的优缺点,分析了2种技术结合的可行性,提出并设计一种适合高速电力线载波通信的CFH-OFDM系统。该系统将混沌跳频技术引入正交频分复用的编码中,提高了系统抗信道噪声的能力,并改进了通信系统的安全性。仿真实验表明,该方法可以提高系统通信的纠错能力,保证通信的可靠性,并为提高低压电力线载波通信系统的信息安全提供一种值得借鉴的方法。     

基于混沌跳频的电力线交织编码技术

可靠性是制约低压电力线载波通信广泛应用的一个重要因素。作为公用网络，低压配电网通信的安全性也日益受到关注。从提高通信可靠性和安全性出发，论述了正交频分复用（OFDM）技术和混沌跳频（CFH）技术在电力线通信上应用的优缺点，分析了2种技术结合的可行性，提出并设计一种适合高速电力线载波通信的CFH-OFDM系统。该系统将混沌跳频技术引入正交频分复用的编码中，提高了系统抗信道噪声的能力，并改进了通信系统的安全性。仿真实验表明，该方法可以提高系统通信的纠错能力，保证通信的可靠性，并为提高低压电力线载波通信系统的信息安全提供一种值得借鉴的方法。     

河蚬酶解物美拉德反应产物抗氧化活性研究

将河蚬软体经酶解制得的河蚬酶解液(Corbicula fluminea hydrolysates,CFH)用超滤法分离得到分子量10 ku、5 ku～10 ku和5 ku三个组分。三种分子量范围酶解液分别与D-木糖进行美拉德反应制备河蚬酶解物美拉德反应产物(CFH-MRP),测定反应前后河蚬酶解物抗氧化能力,pH值、接枝度和褐变程度变化,并对美拉德产物结构进行初步分析。结果表明,通过美拉德反应能够显著提高河蚬酶解物的抗氧化能力,其中5 ku～10 ku的CFH-MRP具有最高的羟基自由基清除率(增加31%)、超氧离子自由基清除率(增加33%)和总还原能力(增加152%),10 ku的CFH-MRP具有最高的DPPH自由基清除能力(增加106%)。同时,美拉德反应使CFH的pH值降低,酶解液褐变程度增加。傅里叶红外光谱(FT-IR)表明CFH和D-木糖发生共价交联,反应产物氨基含量减少;GC-MS分析结果显示反应生成了酮类、酯类、醇类、烯烃、酚类和杂环类物质,在一定程度上提高了反应产物的抗氧化活性。