Drivers of non-revenue water: A cross-national analysis

Reducing water losses is seen as key to sustainable water management, but turns out to be challenging. This paper applies a panel data analysis with fixed effects to assess the major drivers of non-revenue water, some of which are under the control of utilities and some of which are not. The analysis finds that the most important drivers are population density per kilometer of network and type of distribution network, which are mostly resulting from urbanization patterns which are factors mostly out of the control of the utility. Yet, low opportunity costs of water losses and high repair costs of water losses have an important adverse effect on water loss reduction. We also found that the country environment in which the utility operates has an important impact on non-revenue water levels.     

Trajectories of knowledge economy in SSA and MENA countries

In the first critical assessment of knowledge economy dynamic paths in Africa and the Middle East, but for a few exceptions, we find overwhelming support for diminishing cross-country disparities in knowledge-based economy dimensions. The paper employs all the four components of the World Bank's Knowledge Economy Index (KEI): economic incentives, innovation, education, and information infrastructure. The main finding suggests that sub-Saharan African (SSA) and the Middle East and North African (MENA) countries with low levels of KE dynamics and catching-up their counterparts of higher KE levels. We provide the speeds of integration and time necessary to achieve full (100%) integration. Policy implications are also discussed.     

磨矿介质对钼精矿碳含量影响研究

分析研究了低铬合金铸球和复相球墨铸球中碳的赋存状态及其对普通钼精矿、57钼精矿和二硫化钼粉碳含量的影响,指出用浮选法生产低碳57钼精矿,一段磨矿介质不宜使用复相球墨铸球.     

单片机网络在智能化小区中的设计和应用

随着控制技术的发展，控制系统越做越复杂，由单片机构建的控制系统已经由一个单片机组成的系统发展到多个单片机组成的多机控制系统和多个单片机组成的网络系统。在工业监控和民用产品中单片机系统使用的越来越多。随着技术的发展和市场竞争的加剧，生产厂家除了考虑到产品的性能也要考虑到产品成本。Microehip公司的PIC16C57是一款性价比较高的单片机。由该单片机建立起来的系统成本大大降低。本文介绍了一种由PIC16C57单片机建立起来的分级总线型网络系统，系统可以用于工业系统监控和民用楼宇监控系统，该网络系统在硬件和软件上都采取了特别的保护措施，系统具有非常好的稳定性和可靠性。     

Consistent boundary conditions for flows within the atmospheric boundary layer

In computational wind engineering the neutrally stable atmospheric boundary layer (ABL) is often simulated using the standard k-ε model. The application of boundary conditions that are inconsistent with the profiles used at the inflow boundary causes streamwise gradients in the solution and prevents the simulation of a horizontally homogeneous boundary layer. In the present work these problems are overcome by applying a simple extension of the shear stress boundary condition at the top of the domain and by using one-dimensional models to generate inflow profiles in equilibrium with the ground boundary condition. This procedure allows the impact of the inconsistent boundary conditions to be quantitatively assessed. It is shown that inconsistent boundary conditions at the top of the domain result in erroneous streamwise gradients throughout the domain. These errors are reduced by enlarging the domain in the vertical direction but are not removed. The errors are also found in simulations with idealised and real topography included in the domain. A brief discussion of the impact of the errors on simulations of wind energy projects is given.     

On the idea of ex ante and ex post normalization of biproportional methods

Biproportional methods project a matrix A to give it the column and row sums of another matrix; the result is R A S, where R and S are diagonal matrices. As R and S are not identified, one must normalize them, even after computing, that is, ex post. This article starts from the idea developed in de Mesnard (2002) – any normalization amounts to put constraints on Lagrange multipliers, even when it is based on an economic reasoning, – to show that it is impossible to analytically derive the normalized solution at optimum. Convergence must be proved when normalization is applied at each step on the path to equilibrium. To summarize, normalization is impossible ex ante, what removes the possibility of having a certain control on it. It is also indicated that negativity is not a problem.Received: October 2002/Accepted: June 2003     

Design and evaluation of mucoadhesive microemulsion for neuroprotective effect of ibuprofen following intranasal route in the MPTP mice model

Background: The present study is to investigate the neuroprotective effect of ibuprofen by intranasal administration of mucoadhesive microemulsion (MMEI) against inflammation-mediated by dopaminergic neurodegeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson’s disease (PD).

Methods: Ibuprofen-loaded polycarbophil-based MMEI was developed by using response surface methodology (RSM). Ibuprofen with dose of 2.86 mg/kg/day was administered intranasally to male C57BL/6 mice for two consecutive weeks which were pre-treated with four intraperitoneal injections of MPTP (20?mg/kg of body weight) at 2?h intervals. Immunohistochemistry was performed.

Results: Optimal MMEI was stable and non-ciliotoxic with 66.29?±?4.15?nm as average globule size and??20.9?±?3.98?mV as zeta potential. PDI value and transmission electron microscopy result showed the narrow globule size distribution of MMEI. The result showed that all three independent variables had a significant effect (p?<?0.05) on the responses. Rota-rod and open-field test findings revealed the significant improvement in motor performance and gross behavioral activity of the mice. The results from in vivo study and immunohistochemistry showed that nasal administration of Ibuprofen significantly reduced the MPTP-mediated dopamine depletion. Furthermore TH neurons count in the substantia nigra and the density of striatal dopaminergic nerve terminals were found to be significant higher for ibuprofen treated groups.

Conclusion: Findings of the investigation revealed that Ibuprofen through developed MMEI was shown to protect neurons against MPTP-induced injury in the Substantia nigra pars compacta (SNpc) and striatum and hence, could be a promising approach for brain targeting of Ibuprofen through intranasal route to treat PD.     

Impact of the solidification path of FeOx–SiO2 slags on the resultant inorganic polymers

Aiming to reduce the carbon dioxide emissions associated with cement production, alternative binders such as inorganic polymers currently receive substantial attention and slags from the non-ferrous metallurgy are promising precursors. However, studies  that correlate their chemistry and crystallinity with the newly formed binder remain limited. In this work, the effect of three different solidification methods on glass formation and reactivity of FeO_x–SiO₂ slags, as well as on the molecular structure of the resultant Fe-rich inorganic polymers, was investigated. The inorganic polymers were synthesized by mixing the slags (approximate molar ratio FeO/SiO₂ = 1.6) with an alkali silicate solution (molar ratios SiO₂/Na₂O = 1.6 and H₂O/Na₂O = 25). Results demonstrated that higher cooling rates promoted higher glass formation and faster reaction kinetics when the slags were activated. ⁵⁷Fe Mössbauer spectroscopy indicated that all the slags consisted predominantly of Fe²⁺ ions with a minor amount of Fe³⁺ ions, regardless of the variability in glass content. The binder phase of all inorganic polymers consisted of iron in both Fe²⁺ and Fe³⁺ states, after 28 days of curing. After pulverizing the inorganic polymer pastes and exposing the powder to air for 28 additional days, the Fe²⁺ state in the binder transformed to Fe³⁺. The compressive strength evolution of the three slags showed that the 2-day strength was higher for the samples with a higher amorphous fraction, while after 28 days, this influence was less pronounced.     

Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells

Betulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. To overcome this inconvenience, a highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-γ-cyclodextrin). The complex was physico-chemically analyzed using differential scanning calorimetry (DSC), X-ray and scanning electron microscopy (SEM) methods and then in vitro tested for its antiproliferative activity by the MTT assay and by cell cycle analysis. Finally, the complex was tested in vivo using an animal model of murine melanoma developed in C57BL/6J mice, where it caused a reduction in tumor volume and weight. The study revealed the beneficial influence of betulinic acid inclusion into the cyclodextrin in terms of antiproliferative activity and in vivo tumor development.