一种基于S1-MME信令的CSFB寻呼优化

TD-LTE系统是纯IP网络,话音解决方案有单卡双待和话音回落两种,话音回落方案对终端电池的续航能力有较大提升。本文重点介绍TD-LTE系统话音回落的寻呼优化,针对寻呼过程中影响成功率的末端原因进行逐一分析定位,对失败占比较大的寻呼无响应、TAU、干扰进行了详细的分析并给出优化建议。     

基于推理多线程技术的一种改进模型

为了解决多线程处理器不同线程之间并行性低、相互之间数据依赖性高的问题，在推理多线程技术基础上提出了一种新的多线程技术模型(分级多线程Hierarchical Multithreading HMT).该模型采用两种等级处理元的方法，低等级使用指令级并行和细粒度线程级并行；高等级更多地使用间隔并行机制.通过详细的模拟研究，证明分级多线程技术通过对线程的不同粒度采用并行机制能够切实可行地提高线程之间的并行性.     

基于TAU G2地面导弹作战活动可视化建模

提出了一种基于TAUGENERATION2（简称TAUG2）可视化建模方法。通过分析地面导弹作战活动,利用建模工具TAUG2建立了可视化模型,阐明了其相应意义,最后验证了模型的正确性。     

Investigation of the NREL phase VI experiment with the incompressible CFD solver THETA

DLR's incompressible flow solver THETA is introduced for wind turbine applications on the isolated NREL phase VI Unsteady Aerodynamic Experiment rotor. The optimization of parameter settings for the prediction of attached and separated flows on the rotor is performed, including time step size, spatial discretization scheme, turbulence models and Chimera overset grid technique. Afterwards, a systematic study on the pressure distributions, rotor thrust and rotor torque for experimental series S, I and J is performed. The accuracy of results for wind velocities between 7 and 25 m s[[EQUATION1]], covering attached, partly separated and deep stalled flow conditions, is discussed. While good to excellent agreement between THETA sectional pressure distributions and the experimental reference data is achieved in attached flow and deep stall configurations, more efforts are needed to predict partly separated flow cases with comparable accuracy. A code‐to‐code comparison with DLR's compressible flow solver TAU enabled the quantification of differences in pressure prediction because of the use of incompressible and compressible flow solvers. Copyright © 2017 John Wiley & Sons, Ltd.     

海洋模式FVCOM2.6并行计算性能TAU分析

本文利用并行程序分析软件Tuning and Analysis Utilities(TAU),对基于Message Passing Interface(MPI)的海洋环流模式Finite-Volume Coastal Ocean Model(FVCOM)2.6版本进行并行性能分析。在Linux集群(Intel Xeon CPU E5450,10GInfiniBand)上,使用不同进程数分别对低分辨率(网格节点数为2108和10378)、高分辨率(网格节点数为15347和26033)的深沪湾潮汐算例进行测试。结果表明,模式单进程运行时,平流项子程序所占运行时间比例较大;模式多进程运行时,通过比较不同算例的加速比,发现算例分辨率对模式的并行性能有较大影响。在本次测试硬件条件下,算例存在某一最佳进程数,低分辨率为32,高分辨率为64,最佳进程数随分辨率增高而增高。到达最佳进程数后,随着进程数增加,模式运行时间反而增加。TAU分析表明,主要是由于MPI_Waitany程序时间比例增加以致阻塞时间占模式运算总时间的比例增大,从而为FVCOM并行性能进一步改善提供参考。     

AAV-based gene therapy approaches for genetic forms of tauopathies and related neurogenetic disorders

Tauopathies comprise a spectrum of genetic and sporadic neurodegenerative diseases mainly characterized by the presence of hyperphosphorylated TAU protein aggregations in neurons or glia. Gene therapy, in particular adeno-associated virus (AAV)-based, is an effective medical approach for difficult-to-treat genetic diseases for which there are no convincing traditional therapies, such as tauopathies. Employing AAV-based gene therapy to treat, in particular, genetic tauopathies has many potential therapeutic benefits, but also drawbacks which need to be addressed in order to successfully and efficiently adapt this still unconventional therapy for the various types of tauopathies. In this Viewpoint, we briefly introduce some potentially treatable tauopathies, classify them according to their etiology, and discuss the potential advantages and possible problems of AAV-based gene therapy. Finally, we outline a future vision for the application of this promising therapeutic approach for genetic and sporadic tauopathies.     

Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients.

Eleven patients with bipolar depression were given doses of up to 18 g per day of triacetyluridine (TAU) over 6 weeks to test the effect of uridine on symptoms of depression via Montgomery-Asberg Depression Rating Scale (MADRS; Asberg, Montgomery, Perris, Schalling, & Sedvall, 1978) scores and on cellular bioenergetics using phosphorus magnetic resonance spectroscopic imaging (31P-MRSI). All patients and comparison participants (n = 9) completed baseline 31P-MRSI scans, and 9 patients completed posttherapy scans. The percentage changes for MADRS scores (Week 2, -23.8; Week 3, -34.9; Week 4, -42.5) and the time effects of TAU on MADRS scores (Week 2, z = -2.07, p = .039; Week 3, z = -4.28, p     

Candidate Alzheimer’s Disease Biomarker miR-483-5p Lowers TAU Phosphorylation by Direct ERK1/2 Repression

MicroRNAs have been demonstrated as key regulators of gene expression in the etiology of a range of diseases including Alzheimer’s disease (AD). Recently, we identified miR-483-5p as the most upregulated miRNA amongst a panel of miRNAs in blood plasma specific to prodromal, early-stage Alzheimer’s disease patients. Here, we investigated the functional role of miR-483-5p in AD pathology. Using TargetScan and miRTarBase, we identified the microtubule-associated protein MAPT, often referred to as TAU, and the extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), known to phosphorylate TAU, as predicted direct targets of miR-483-5p. Employing several functional assays, we found that miR-483-5p regulates ERK1 and ERK2 at both mRNA and protein levels, resulting in lower levels of phosphorylated forms of both kinases. Moreover, miR-483-5p-mediated repression of ERK1/2 resulted in reduced phosphorylation of TAU protein at epitopes associated with TAU neurofibrillary pathology in AD. These results indicate that upregulation of miR-483-5p can decrease phosphorylation of TAU via ERK pathway, representing a compensatory neuroprotective mechanism in AD pathology. This miR-483-5p/ERK1/TAU axis thus represents a novel target for intervention in AD.     

Supporting Nested OpenMP Parallelism in the TAU Performance System

Nested OpenMP parallelism allows an application to spawn teams of nested threads. This hierarchical nature of thread creation and usage poses problems for performance measurement tools that must determine thread context to properly maintain per-thread performance data. In this paper we describe the problem and a novel solution for identifying threads uniquely. Our approach has been implemented in the TAU performance system and has been successfully used in profiling and tracing OpenMP applications with nested parallelism. We also describe how extensions to the OpenMP standard can help tool developers uniquely identify threads.     

WRF三维变分同化并行程序性能分析

并行程序性能分析在科学计算程序设计和优化中发挥着重要作用，通过它可以了解并行程序运行效率，分析计算瓶颈，从而改进和优化程序设计，更好地发挥高性能计算机效 能。本文介绍了WRF三维变分同化原理和并行策略，采用性能分析工具TAU对WRF三雏变分同化并行程序运行效率进行了量化分析，确定了程序的计算热点和瓶颈，并提出了相应的优化方案。