Testosterone Reduces Knee Passive Range of Motion and Expression of Relaxin Receptor Isoforms via 5α-Dihydrotestosterone and Androgen Receptor Binding

Ovarian steroids such as estrogen and progesterone have been reported to influence knee laxity. The effect of testosterone, however, remains unknown. This study investigated the effect of testosterone on the knee range of motion (ROM) and the molecular mechanisms that might involve changes in the expression of relaxin receptor isoforms, Rxfp1 and Rxfp2 in the patella tendon and lateral collateral ligament of the female rat knee. Ovariectomized adult female Wistar rats received three days treatment with peanut oil (control), testosterone (125 and 250 μg/kg) and testosterone (125 and 250 μg/kg) plus flutamide, an androgen receptor blocker or finasteride, a 5α-reductase inhibitor. Duplicate groups received similar treatment however in the presence of relaxin (25 ng/kg). A day after the last drug injection, knee passive ROM was measured by using a digital miniature goniometer. Both tendon and ligament were harvested and then analysed for protein and mRNA expression for Rxfp1 and Rxfp2 respectively. Knee passive ROM, Rxfp1 and Rxfp2 expression were significantly reduced following treatment with testosterone. Flutamide or finasteride administration antagonized the testosterone effect. Concomitant administration of testosterone and relaxin did not result in a significant change in knee ROM as compared to testosterone only treatment; however this was significantly increased following flutamide or finasteride addition. Testosterone effect on knee passive ROM is likely mediated via dihydro-testosterone (DHT), and involves downregulation of Rxfp1 and Rxfp2 expression, which may provide the mechanism underlying testosterone-induced decrease in female knee laxity.     

基于CFD/CSD耦合的超声速舵面动载荷计算

该文分析了超声速气动控制舵面在瞬态气动载荷作用下的位移及应力的时域变化.采用基于Volterra级数的气动弹性系统降阶模型快速获得了舵面的颤振边界.通过CFD/CSD耦合计算,确定了舵面在颤振速度下的瞬态气动载荷,并利用参数空间下的有限元四结点方法将每一时刻的气动载荷插值并施加到结构结点上,进行了瞬态响应分析,得到了舵...     

抗辐照SOI256kB只读存储器的ESD设计

ESD设计技术已成为业界提升SOI电路可靠性的一个瓶颈技术。文章介绍了一款具有抗辐照能力、基于SOI／CMOS工艺技术研制的容量为256kB只读存储器电路的ESD设计方案。结合电路特点详细分析了其ESD设计的难点,阐述了从工艺、器件和电路三个方面如何密切配合,进行SOI电路ESD设计的分析思路和解决方法。电路基于0．8...     

基于RS-232的FLASH在线编程研究

以TMS320F2812为基础,详细分析了该芯片上电后系统的引导过程,针对此类以MCU／DSP为核心的嵌入式产品升级、维护时FLASH编程不便的问题,依据其内部固化的BootROM以及FLASHAPI的原理,介绍了一种基于RS-232的FLASH编程方法。这种方法较传统FLASH编程,具有编程方便、快捷、成本低等优点,并在实验中验证了结果,此方法可行。     

Small Area ROM Design for Embedded Applications

The compact full custom layout design of a 16 kbit mask-programmable complementary metal oxide semiconductor (CMOS) read only memory (ROM) with low power dissipation is introduced. By optimizing storage cell size and peripheral circuit structure, the ROM     

无双线性对的无证书安全签密方案

已有的无双线性对的无证书签密方案,大都存在着机密性漏洞和签名选择性伪造问题。针对此问题,基于有限乘法交换群上的离散对数难题,提出一种无双线性对的无证书签密方案,并进行了安全分析和证明。指出采用随机预言模型的证明方法可能忽略不解决DL难题时对签密方案的攻击,不能证明破解签密方案的难度与解决DL难题相等价。通过对参数的数学分析,证明了破解本签密方案的必要条件是解决DL难题,不存在不解决DL难题攻击本签密方案的多项式时间算法。与已知所有方案相比,所提方案安全性更高。     

基于DMI校验的PCI ROM保护算法

PCI ROM广泛存在于显卡、网卡、RAID卡、硬盘保护卡等PCI设备中。通过对PCI、SMBIOS、DMI规范和相关算法的研究,介绍了DMI的功用,探讨了DMI在BIOS中的位置及通过SMBIOS访问DMI的方式,说明了POST代码处理ROM的流程。针对PCI ROM保护的问题,提出了一种通过校验DMI来决定是否执行PCI ROM的方法。     

一种匿名认证密钥协商协议*

大多数的认证密钥协商协议没有考虑用户的匿名性,在分析已有MAKAP协议的基础上,提出了一种具有用户匿名性的认证密钥协商协议AKAPA,为用户提供隐私保护。在随机预言机模型下证明其安全性,并就增强的安全属性进行了分析,表明AKAPA具有完美前向安全性,能够抗未知共享密钥攻击和完善拒绝服务攻击等。性能分析表明效率优于已有协议,具有较高的实用性。     

一种高速直接数字频率合成器及其FPGA实现

介绍了一种用于QAM调制和解调的直接数字频率合成器,该电路同时输出10位正弦和余弦两种波形,系统时钟频率为50MHz,信号的谐波小于－72dB。输出信号的范围为DC到25MHz,信号频率步长为0．0116Hz,相应的转换速度为20ns,建立时间延迟为4个时种。直接数字合成器（DDFS）采用一种有效查找表的方式生成正弦函数,为了降低ROM的大小,采用了1／8正弦波形函数压缩算法。直接数字频率合成器的数字部分由Xilinx FPGA实现,最后通过数模转换器输出。