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1.
Atherothrombosis exposes vascular components to blood. Currently, new antithrombotic therapies are emerging. Herein we investigated thrombogenesis of human arteries with/without atherosclerosis, and the interaction of coagulation and vascular components, we and explored the anti-thrombogenic efficacy of blockade of the P2X purinoceptor 7 (P2X7). A confocal blood flow videomicroscopy system was performed on cryosections of internal mammary artery (IMA) or carotid plaque (CPL) determining/localizing platelets and fibrin. Blood from healthy donors elicited thrombi over arterial layers. Confocal microscopy associated thrombus with tissue presence of collagen type I, laminin, fibrin(ogen) and tissue factor (TF). The addition of antibodies blocking TF (aTF) or factor XI (aFXI) to blood significantly reduced fibrin deposition, variable platelet aggregation and aTF + aFXI almost abolished thrombus formation, showing synergy between coagulation pathways. A scarce effect of aTF over sub-endothelial regions, more abundant in tissue TF and bundles of laminin and collagen type I than deep intima, may suggest tissue thrombogenicity as molecular structure-related. Consistently with TF-related vascular function and expression of P2X7, the sections from CPL but not IMA tissue cultures pre-treated with the P2X7 antagonist A740003 demonstrated poor thrombogenesis in flow experiments. These data hint to local targeting studies on P2X7 modulation for atherothrombosis prevention/therapy.  相似文献   
2.
An signal noise ratio (SNR) adaptive sorting algorithm using the time-frequency (TF) sparsity of frequency-hopping (FH) signal is proposed in this paper.Firstly,the Gabor transformation is used as TF transformation in the system and a sorting model is established under undetermined condition;then the SNR adaptive pivot threshold setting method is used to find the TF single source.The mixed matrix is estimated according to the TF matrix of single source.Lastly,signal sorting is realized through improved subspace projection combined with relative power deviation of source.Theoretical analysis and simulation results show that this algorithm has good effectiveness and performance.  相似文献   
3.
Nowadays, we can use different websites that help us make decisions about various aspects of our lives. However, privacy protection prevents websites from providing personalised guidelines to users. We propose a novel doctor‐ranking system (DRS) based on multi‐criteria group decision‐making (MCGDM) method to address the problems of privacy protection. The following aspects differentiate our proposed DRS model from previous works: (a) textual information reviews are used to identify user preferences and complementary criteria, (b) criteria weights are determined by term frequency inverse document frequency (TF‐IDF) instead of Delphi method or expert opinion, (c) intuitionistic fuzzy sets (IFSs) are used to replace sentiment analysis to express subjective user criteria, and (d) VIsekriterijumsko KOmpromisno Rangiranjie (VIKOR) method for MCGDM with IFSs is used to solve the doctor‐ranking problem. We apply our proposed model to datasets from Haodf.com to compare the performance of our method with that of sentiment analysis and technique for order performance by similarity to ideal solution (TOPSIS) methods. The experimental results show that our method provides accurate ranking and increases the reliability of DRS.  相似文献   
4.
本文研究了重金属和石油烃复合污染土壤中,腐植酸对草本植物吸收重金属的影响。结果显示:腐植酸大幅度地降低了污染土壤中可溶性和交换态重金属含量,但提高了植物可利用态重金属含量。土壤添加腐植酸后,除Ni外,重金属潜在生物有效性和可淋出性因子大于1,这表明大多数重金属对植物具有潜在的有效性。此外,腐植酸增加了铅(Pb)、铜(Cu)、镉(Cd)和镍(Ni)在供试植物幼苗和根部的积累,最高的是高羊茅幼苗,达264.7%,生物富集系数从0.30提高到1.10。芸苔根中Ni和Pb的生物富集系数也有所提高。这些研究结果表明,石油烃与重金属同时污染的情况下,加入腐植酸可以促进植物吸收重金属,但降低重金属淋失,防止地下污染。  相似文献   
5.
低温贮藏对脆肉鲩鱼肉肌动球蛋白特性的影响   总被引:2,自引:0,他引:2  
以脆肉鲩为对象,研究低温贮藏条件对鱼肉肌动球蛋白性质的影响。结果表明:随着贮藏时间的延长,脆肉鲩肌肉中肌动球蛋白溶出量、Ca2+-ATPase活性、巯基和活性巯基含量下降、表面疏水性上升;贮藏温度对蛋白特性的影响显著,贮藏温度越高,Ca2+-ATPase活性和巯基含量越低,表面疏水性越高。  相似文献   
6.
为研制基于BIM技术的建筑节能设计软件,需要实现从IFC数据到能耗模拟软件所需数据的转换。目前国内外已经有一些相关研究,但其具体转换机制和算法并未公开,也没有实现商业化应用。本研究首先建立了建筑节能设计信息需求模型,然后通过分析IFC标准和主流能耗模拟内核EnergyPlus的IDF格式分别建立起了基于IFC标准和IDF格式的建筑节能设计信息模型,之后在该模型的基础上,通过解决一些关键算法建立并实现了由节能设计IFC数据生成IDF数据的转换机制。实际工程的应用表明所建立的机制能大大提高建模效率。本研究为开发基于BIM技术的我国建筑节能设计软件奠定了基础。  相似文献   
7.
Steady State Superconducting Tokamak-1 (SST-1) at Institute for Plasma Research (IPR), India is now in engineering validation phase. The assembled Toroidal Field (TF) magnet system of SST-1 will be operated at 10 kA of nominal current at helium cooled condition of 4.5 K. A reliable and fail proof quench detection (QD) system is essential for the safety and the investment protection requirements of the magnets. This QD system needs to continuously monitor all the superconducting coils, which include 16 TF magnets, return-loop, bus bars and current leads. In case of any event initiating the normal resistive zone and reaching thermal run-away, the QD system needs to trigger the magnet protection circuits. Precision instrumentation and control system with 204 signal channels had been developed for detection of quench anywhere in the entire TF magnet system. In the present configuration of quench detection scheme, the voltage drop across each double pancake (DP) of each TF coil are compared with its two adjacent DPs for the detection of normal zone and cancelation of inductive couples. Two identical redundant systems with one out of two configurations are successfully commissioned and tested at IPR. This paper describes the design and implementation of the QD system, Installation experience, validation test and initial results from the recent SST-1 magnet system charging.  相似文献   
8.
针对目前用户在使用搜索引擎过程中,检索结果冗余、效率低下等问题,本文在对文献垂直搜索系统中Lucene.Net的索引算法研究基础上,结合用户实际专业检索需求,改变其算法中的激励因子,实验结果证明该方法确能提高搜索结果的相关度.  相似文献   
9.
Thomsen–Friedenreich (TF) antigen is an important tumor‐associated carbohydrate antigen. Its low immunogenicity, however, limits its application in the development of anticancer vaccines. To solve this problem, several N‐acyl‐modified TF derivatives were synthesized and conjugated with carrier protein CRM197 (a mutated diphtheria toxoid cross‐reactive material). The immunological results in BALB/c mice demonstrated that these modified TF antigen conjugates could stimulate the production of higher titers of IgG antibodies that cross‐reacted with native TF antigen. These glycoconjugates showed strong lymphocyte proliferative response, suggesting that they can induce cellular immunity. Furthermore, the elicited antisera reacted strongly with TF‐positive tumor cells (4T1). In particular, the N‐monofluoroacetyl‐modified TF conjugate 4 ‐CRM197 showed the strongest complement‐dependent cytotoxicity effect against 4T1 cells, implying the potential of this glycoconjugate as an anticancer vaccine.  相似文献   
10.
随着汽动引风机在新建1000MW级汽轮发电机组中被逐步应用,相关的辅机故障减负荷(run back,RB)试验受到了越来越多的关注。基于对某台采用汽动引风机的1000MW级汽轮发电机组在调试、RB试验中出现问题的分析和总结,提出了送、引风机控制逻辑的优化策略。通过RB试验的严峻考验,证明了该优化策略的可行性,可为其他采用汽动引风机的机组提供相关借鉴。  相似文献   
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