Multiproject lineage management: Bridging project management and design-based innovation strategy

Innovation-based strategies are widely recognized as key drivers to maintain competitive advantage. The design and strategic literature underline the possibility of triggering a multiproduct value-expansion dynamic based on the creation of new concepts dynamically twinned with corporate strategy. However, the multiproject-management literature—portfolio, program, and platform—lags behind and remains focused on ex ante coordination, resource allocation and selectionism. Thus, there are still few indications of the processes that stimulate and orient continuous, profitable multiproject creative expansion. Bridging the multiproject-management literature and design theory, we propose a model of multiproject lineage management (MPLM), which focuses on the key processes that drive exploration efforts and shape innovation trajectory. We conduct a multiple longitudinal case analysis in the automobile sector. Based on this analysis, we expose the principles of MPLM, mapping the roles of corporate, program and project management within a global expansion project. Finally, we highlight our contributions to managerial practices and the related literature.     

CD20在成年人急性B淋巴细胞白血病中的表达及其临床意义

目的 检测CD20在成年人急性B淋巴细胞白血病(B-ALL)的表达,探讨其与临床特点的相关性.方法 回顾性总结分析96例成年B-ALL患者CD20表达情况,结合其临床特性和治疗转归进行分析.结果 96例成年B-ALL患者中,CD20阳性29例(30.20%),CD20阴性67例(69.79%).CD20阳性组与阴性组男女比分别为1.42∶1和1.79∶1(x2=0.27,P＞0.05),中位年龄分别为28岁与23岁,肝脾及淋巴结浸润比例分别为44.83%和41.38%、40.30%和35.82%,髓系抗原表达比例分别为51.72%与56.72%,Ph染色体和bcr-abl融合基因阳性比例分别为24.14%与28.36%,4周内完全缓解率分别为73.08%与68.85%,差异均无统计学意义(P值均＞0.05).在复发率和3年总体生存率上,CD20阳性组分别为54.55%与14.80%,CD20阴性组分别为29.63%与37.30%,两组间差异有统计学意义(x2=0.42,x2=5.31;P值均＜0.05).结论 CD20在成年人B-ALL表达与临床特点无相关性,但对判断患者的预后有一定的指导意义.     

A Bi‐Lineage Conducive Scaffold for Osteochondral Defect Regeneration

Because cartilage and bone tissues have different lineage‐specific biological properties, it is challenging to fabricate a single type of scaffold that can biologically fulfill the requirements for regeneration of these two lineages simultaneously within osteochondral defects. To overcome this challenge, a lithium‐containing mesoporous bioglass (Li‐MBG) scaffold is developed. The efficacy and mechanism of Li‐MBG for regeneration of osteochondral defects are systematically investigated. Histological and micro‐CT results show that Li‐MBG scaffolds significantly enhance the regeneration of subchondral bone and hyaline cartilage‐like tissues as compared to pure MBG scaffolds, upon implantation in rabbit osteochondral defects for 8 and 16 weeks. Further investigation demonstrates that the released Li+ ions from the Li‐MBG scaffolds may play a key role in stimulating the regeneration of osteochondral defects. The corresponding mechanistic pathways involve Li+ ions enhancing the proliferation and osteogenic differentiation of bone mesenchymal stem cells (BMSCs) through activation of the Wnt signalling pathway, as well as Li+ ions protecting chondrocytes and cartilage tissues from the inflammatory osteoarthritis (OA) environment through activation of autophagy. These findings suggest that the incorporation of Li+ ions into bioactive MBG scaffolds is a viable strategy for fabricating bi‐lineage conducive scaffolds that enhance regeneration of osteochondral defects.     

从数字设计到数字管控:第四代城市设计范型的威海探索

当今中国城镇化中后期呈现出品质化的需求,加上原有的快速度和大尺度特征,普遍面临着城市形态的科学布局和精细管控的新课题,尤其在数字化时代,需要从新的视角探索“数字化分析—数字化设计—数字化管理”的整体解决方案。以成海为研究样本,针对城市的现状特征和发展目标,通过数字化城市设计范型的理论与方法研究,探索城市三维空间形态科学布局和有效管控之道,为营造精致城市提供途径。借助于人机互动的数字化技术,从环境生态、空间形态、人群动态、功能业态等方面充分挖掘城市内在规律,更加精确理性地把握城市特色,营造精细雅致的宜居城市。在深入研究城市设计管控要素的基础上,挖掘数字化技术在规划管理工作中的潜在优势,建构城市设计数字化管控平台,以提升管理实施的效率与质量。依托数字化平台,集成智能管控规则,实现多尺度、多类型城市设计管控要素的集成化、智能化、实时化,为城市设计的管理实施提供有效途径。     

Traceable P2P record exchange: a database-oriented approach

In recent years, peer-to-peer (P2P) technologies are used for flexible and scalable information exchange in the Internet, but there exist problems to be solved for reliable information exchange. It is important to trace how data circulates between peers and how data modifications are performed during the circulation before reaching the destination for enhancing the reliability of exchanged information. However, such lineage tracing is not easy in current P2P networks, since data replications and modifications are performed independently by autonomous peers—this creates a lack of reliability among the records exchanged. In this paper, we propose a framework for traceable record exchange in a P2P network. By managing historical information in distributed peers, we make the modification and exchange histories of records traceable. One of the features of our work is that the database technologies are utilized for realizing the framework. Histories are maintained in a relational database in each peer, and tracing queries are written in the datalog query language and executed in a P2P network by cooperating peers. This paper describes the concept of the framework and overviews the approach to query processing.     

数据起源技术发展研究综述*

在总结国内外相关文献基础上,系统介绍了数据起源的概念、内容及其主要应用,介绍了数据起源的基础研究和开放环境下两个典型的形式化模型,然后介绍了其在数据库和工作流及其他领域的应用,对现有成熟的起源管理系统进行了分析和比较,最后展望了数据起源技术的发展方向。     

黄伯思世系考辨

为深入研究《东观余论》,根据众多文献考辨出宋人黄伯思与李纲为中表襟姻;娶张氏,生男二人黄诏和黄讠乃,生女一人;其父为黄应求,祖父为黄履,曾祖为黄汝济,并世居邵武;黄伯思是黄膺的十二世孙,是黄峭山的旁系九世孙。