| 常见温度敏感型原位凝胶研究及应用进展 |
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| 引用本文： | 赵健铤,刘衡,李贵轲,张成桂,巫秀美,赵昱,高鹏飞.常见温度敏感型原位凝胶研究及应用进展[J].广州化工,2013(24):9-11. |
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| 作者姓名： | 赵健铤 刘衡 李贵轲 张成桂 巫秀美 赵昱 高鹏飞 |
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| 作者单位： | 云南省药用昆虫及蛛形类资源利用开发工程实验室,云南省昆虫生物医药研发重点实验室（大理学院）,云南大理671000 |
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| 基金项目： | 云南省高层次人才培引工程（No.2009C1121）;国家自然科学基金（No.81260676）;云南省教育厅科学研究基金（No.20132154）. |
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| 摘 要： | 温度敏感型原位凝胶是现在国内外研究新型药物传递系统的一个热点，因具有良好的流动性、较长的滞留时间、高效的生物利用度及良好的控制释药性能等优点成为了新型给药系统的主要研究对象。本文以近年来国内外研究温度敏感型原位凝胶的相关文献，对其基质选择、给药途径及质量控制的研究进行综述，从而为温度敏感型原位凝胶的新型药物研发提供一定的借鉴和参考。
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| 关 键 词： | 温度敏感型原位凝胶 基质 给药途径 质量控制 |
Research and Application Progress of Thermo - sensitive Gels |
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| ZHAO Jian-ting,LIU Heng,LI Gui-ke,ZHANG Cheng-gui,WU Xiu-mei,ZHAO Yu,GAO Peng-fei.Research and Application Progress of Thermo - sensitive Gels[J].GuangZhou Chemical Industry and Technology,2013(24):9-11. |
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| Authors: | ZHAO Jian-ting LIU Heng LI Gui-ke ZHANG Cheng-gui WU Xiu-mei ZHAO Yu GAO Peng-fei |
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| Affiliation: | (The Key Laboratory of Medical Insects and Spiders Resources for Development ＆ Utilization, Yunnan Province, Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R ＆ D, Dali University, Yunnan Dali 671000, China) |
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| Abstract: | Thermosensitive gels was a hot spot of which had a good liquidity, longer retention time, high research at home and abroad new drug delivery systems now, bioavailability and good control of drug release performance advantages, so it became a new drug delivery system of the main research object. Based on the research at home and abroad in recent years, its type of matrix selection, routes of administration and quality control of research were summarized, so as to provide certain reference for developing new drugs of thermo -sensitive gels. |
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| Keywords: | thermo - sensitive gels matrix routes of administration quality control |
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