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| Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by ^12C^6＋ ions | |
| 引用本文： | LIU Yang ZHANG Hong ZHANG Luwei. Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by ^12C^6＋ ions[J]. 核技术(英文版), 2008, 19(1): 17-21. DOI: 10.1016/S1001-8042(08)60016-0 |
| 作者姓名： | LIU Yang ZHANG Hong ZHANG Luwei |
| 作者单位： | [1]Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China [2]Gansu Agricultural University, Lanzhou 730070, China |
| 基金项目： | Supported by grants from the National Natural Science Foundation of China （10675151）, the Key Scientific Technology Research Projects of Gansu Province （2GS052-A43-008-02, 2GS063-A43-012, O702NKDA045）, the Scientific Technology Research Project of Lanzhou-Chinese Academy of Sciences （07-2-07） and the Program of Western Light （O760160XB0）Acknowledgements We express our thanks to the accelerator crew at the HIRFL, National Laboratory of Heavy Ion Accelerator in Lanzhou. |
| 摘 要： | The aim of this work is to identify if there is sex specificity on ^12C^6＋ ion-induced oxidative damage in mouse lung at different time points. Kun-Ming mice were divided into two groups, each composed of six males and six females： control group and irradiation group with a single acute dose of 4 Gy. Animals were sacrificed at 2, 4 and 12 h respectively, there lungs were removed immediately, and the oxidative stress-related biomarkers were measured by Diagnostic Reagent Kits. The results showed that the relative activities of superoxide dismutase （4 h）, catalase （2 h） and Se-dependent glutathione peroxidase （12 h） have significant changes （P〈0.05） between male groups and female groups, suggesting that the lungs of male mice are more sensitive to counteracting the oxidative challenge. Moreover, higher levels of malondiadehyde and lower contents of glutathione were also found in males, indicating that oxidative stress induced by ^12C^6＋ ion is pronounced in the lungs of males. We thought that these sex-responded differences may be attributed to the influence of sex hormones. |
| 关 键 词： | 性别特性 电离辐射 小鼠 动物实验 生物体 |
| 收稿时间： | 2007-10-16 |
Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by C ions |
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| Yang LIU, Hong ZHANG,Luwei ZHANG. Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by C ions[J]. , 2008, 19(1): 17-21. DOI: 10.1016/S1001-8042(08)60016-0 | |
| Authors: | Yang LIU Hong ZHANG Luwei ZHANG |
| Affiliation: | aDepartment of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;bGansu Agricultural University, Lanzhou 730070, China |
| Abstract: | The aim of this work is to identify if there is sex specificity on 12C6+ ion-induced oxidative damage in mouse lung at different time points. Kun-Ming mice were divided into two groups, each composed of six males and six females: control group and irradiation group with a single acute dose of 4 Gy. Animals were sacrificed at 2, 4 and 12 h respectively, there lungs were removed immediately, and the oxidative stress-related biomarkers were measured by Diagnostic Reagent Kits. The results showed that the relative activities of superoxide dismutase (4 h), catalase (2 h) and Se-dependent glutathione peroxidase (12 h) have significant changes (P<0.05) between male groups and female groups, suggesting that the lungs of male mice are more sensitive to counteracting the oxidative challenge. Moreover, higher levels of malondiadehyde and lower contents of glutathione were also found in males, indicating that oxidative stress induced by 12C6+ ion is pronounced in the lungs of males. We thought that these sex-responded differences may be attributed to the influence of sex hormones. |
| Keywords: | Sex specificity Oxidative stress 12C6 ion Mouse lung |
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