| Synthesis of highly concentrated,carrier free ^188Re—mercaptoacetyltriglycine |
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| 引用本文： | ZHANGXiu－Li WANGYong－Xian 等. Synthesis of highly concentrated,carrier free ^188Re—mercaptoacetyltriglycine[J]. 核技术(英文版), 2002, 13(4): 237-243 |
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| 作者姓名： | ZHANGXiu－Li WANGYong－Xian 等 |
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| 作者单位： | ShanghaiInstituteofNuclearResearch,theChineseAcademyofSciences,Shanghai201800 |
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| 基金项目： | Supported partially by Key Project of Knowledge Innvation Program of the Chinese Academy of Sciences (KJCX1-sw-08) |
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| 摘 要： | Chelation of ^188Re to compounds such as MAG3 will further reduce the radiation dose to the patient in case of balloon rupture through the rapid excretion from the body.In order to prepae highly concentrated,carrier free ^188Re-MAG3,Sbenzoyl mercaptoacetyltriglycine(S-Bz-MAG3) was synthesized.labeled with carrier free ^188Re.the overall yield of S-Bz-MAG3 is higher than those published in the literature,Dependence of the labeling yield of ^188Re-MAG3 upon concentrations of reducing agent,pH,reaction time,etc.was examined and optimum conditions were confirmed.The concentration procedure was succeeded with Sep-Pak C18 cartridge to obtain highly concentrated ^188Re-MAG3.In the case of optimun conditions.the labeling yield of 188Re-MAG3 was more than 98%.Radiochemical purity of ^188ReMAG3 was more than 92% after 24 hour storage at room temperature.
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| 关 键 词： | 放射同位素 ^188Re 放射免疫疗法 |
Synthesis of highly concentrated, carrier free 188Re-mercaptoacetyltriglycine |
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| ZHANG Xiu-Li,WANG Yong-xian,LI Jun-Ling,ZHANG Chun-fu,WANG Li-Hua,YIN Duan Zhi. Synthesis of highly concentrated, carrier free 188Re-mercaptoacetyltriglycine[J]. , 2002, 13(4): 237-243 |
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| Authors: | ZHANG Xiu-Li WANG Yong-xian LI Jun-Ling ZHANG Chun-fu WANG Li-Hua YIN Duan Zhi |
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| Abstract: | Chelation of 188Re to compounds such as MAG3 will further reduce the radiation dose to the patient in case of balloon rupture through the rapid excretion from the body. In order to prepare highly concentrated, carrier free 188Re-MAG3, S-benzoyl mercaptoacetyltriglycine (S-Bz-MAG3) was synthesized, labeled with carrier free 188Re. The overall yield of S-Bz-MAG3 is higher than those published in the literature. Dependence of the labeling yield of 188Re-MAG3 upon concentrations of reducing agent, pH, reaction time, etc. was examined and optimum conditions were confirmed. The concentration procedure was succeeded with Sep-Pak C18 cartridge to obtain highly concentrated 188Re-MAG3. In the case of optimun conditions, the labeling yield of 188Re-MAG3 was more than 98%. Radiochemical purity of 188Re-MAG3 was more than 92% after 24 hour storage at room temperature. |
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| Keywords: | 188Re-MAG3 Synthesis Labeling Carrier free RIT |
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