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Presence of Potential G-Quadruplex RNA-Forming Motifs at the 5′-UTR of PP2Acα mRNA Repress Translation |
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| Authors: | Sushree Prangya P Pany Mahak Sapra Jitendar Sharma Dr V Dhamodharan Prof Swati Patankar Dr P I Pradeepkumar |
| Affiliation: | 1. Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, 400076 India;2. Centre for Research in Nanotechnology and Science, Indian Institute of Technology Bombay, Mumbai, 400076 India;3. Department of Bioscience and Bioengineering, Indian Institute of Technology Bombay, Mumbai, 400076 India |
| Abstract: | RNA G-quadruplex (G4)-forming motifs present at the 5′-UTR of the protein phosphatase (PP2Ac) gene are the regulatory targets of the fragile X mental retardation protein (FMRP), which is weakly expressed in Fragile X patients. Herein, we report that the existence of such G4-forming sequence represses the translation of the PP2Acα gene. This study opens therapeutic avenues to design small molecule ligands that mimic the function of the FMRP. |
| Keywords: | FMRP G-quadruplexes PP2Ac-alpha RNA translation |