| 接枝聚阳离子磁性微球的合成及抗菌活性 |
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| 引用本文： | 王静云,李瑞法,包永明.接枝聚阳离子磁性微球的合成及抗菌活性[J].功能材料,2011(S5). |
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| 作者姓名： | 王静云 李瑞法 包永明 |
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| 作者单位： | 大连理工大学生命科学与技术学院; |
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| 摘 要： | 共沉淀法合成Fe3O4纳米颗粒,经硅烷偶联剂3-(异丁烯酰氧)丙基三甲氧基硅烷(MPS)表面双键功能化,与季铵盐化(苄基溴化或溴己烷化)甲基丙烯酸二甲基氨基乙酯(DMAEMA)单体自由基共聚,获得可循环利用的聚阳离子接枝的磁性抗菌微球(pQAC-Fe3O4)。颗粒形貌及表面性质通过X射线衍射(XRD)、红外(FT-IR)、动态光散射粒径分析(DLS)、透射电镜(TEM)、热重分析(TGA)等表征。测试pQAC-Fe3O4微球对革兰氏阳性、革兰氏阴性菌及真菌的抗菌活性,结果表明两种具有外磁场响应性的pQAC-Fe3O4颗粒均具有高效广谱杀菌性,且经磁分离回收循环利用10次后对大肠杆菌的杀菌率仍可达95%以上。颗粒杀菌效果不仅与接枝季铵盐基团的多少有关还与季铵盐取代基团有关。
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| 关 键 词： | 抗菌材料 磁性纳米颗粒 表面修饰 接枝聚合 聚季铵盐 |
Preparation and antibacterial character of polymeric quaternary ammonium salts grafted Fe_3O_4 nanoparticles |
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| WANG Jing-yun,LI Rui-fa,BAO Yong-ming.Preparation and antibacterial character of polymeric quaternary ammonium salts grafted Fe_3O_4 nanoparticles[J].Journal of Functional Materials,2011(S5). |
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| Authors: | WANG Jing-yun LI Rui-fa BAO Yong-ming |
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| Affiliation: | WANG Jing-yun,LI Rui-fa,BAO Yong-ming (School of Life Science & Biotechnology,Dalian University of Technology,Dalian 116024,China) |
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| Abstract: | Fe3O4 nanoparticles prepared by coprecipitation method were surface functionalized with the silane coupling agent of 3-methacryloylpropyl trimethoxysilane(MPS),then the MPS on the surface of Fe3O4 nanoparticles was copolymerized with the quaternary ammonium salt monomers(quaternization of dimethylaminoethyl methacrylate with benzyl bromide or bromohexane) by free radical polymerization,and the recyclable antibacterial polycation grafted Fe3O4 magnetic nanoparticles(pQAC-Fe3O4) were obtained.The morphology a... |
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| Keywords: | antibacterial material magnetic nanoparticles surface modification grafting polymerization polymeric quaternary ammonium salts |
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