| 6,7-二(2-甲氧基乙氧基)喹唑啉-4-酮的合成 |
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| 引用本文： | 陈海群,胡健华.6,7-二(2-甲氧基乙氧基)喹唑啉-4-酮的合成[J].化学世界,2010,51(4). |
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| 作者姓名： | 陈海群 胡健华 |
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| 作者单位： | 江苏工业学院江苏省精细化工重点实验室,江苏常州,213164 |
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| 摘 要： | 以3,4-二羟基苯甲酸乙酯为原料,通过醚化、硝化、还原、成环四步反应合成新型抗癌药物中间体6,7-二(2-甲氧基乙氧基)喹唑啉-4-酮,改进了工艺,考察了各类工艺条件对目标产物收率的影响,得到最适宜反应条件,在优化条件下,总收率为83.7%。
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| 关 键 词： | 6 7-二(2-甲氧基乙氧基)喹唑啉-4-酮 3 4-二羟基苯甲酸乙酯 抗癌药物 |
Synthesis of 6,7-Bis(2-methoxyethoxy)quinazolin-4(3 H)-one |
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| CHEN Hai-qun,HU Jian-hua.Synthesis of 6,7-Bis(2-methoxyethoxy)quinazolin-4(3 H)-one[J].Chemical World,2010,51(4). |
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| Authors: | CHEN Hai-qun HU Jian-hua |
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| Abstract: | 6,7-Bis(2-methoxyethoxy)quinazolin-4(3H)one was prepared through etherification nitration,reduction and cyclization from the starting material ethyl 3,4-dihydroxybenzoate.The synthetic process was improved,and the optimum conditions for the reaction were determined with an overall yield of 83.7%. |
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| Keywords: | 6 7-bis(2-methoxyethoxy)quinazolin-4(3H)-one ethyl 3 4-dihydroxybenzoate anticancer drug |
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