同位素稀释—气相色谱—质谱法同时测定婴幼儿配方奶粉中8种己二酸酯塑化剂

建立了一种同位素稀释—气相色谱—质谱法同时测定婴幼儿配方奶粉中8种己二酸酯增塑剂含量的方法。婴幼儿配方奶粉样品以水溶解完全后,选用正己烷作为萃取溶剂,经超声提取后采用GC-MS选择离子模式对8种目标物进行定性、定量分析。方法具有良好线性,相关系数R20.999。检出限为0.08～0.12mg/kg,定量限为0.2～0.4mg/kg,加标回收率为94.8%～103.3%,相对标准偏差(RSD)8.1%。该方法快速、简单、灵敏度高、重复性好,适用于婴幼儿配方奶粉样品中多种己二酸酯含量的测定。

Simultaneous determination of 8 adipate plasticizers in infant formula by isotope dilution-gas chromatography-mass spectrometry

A method was developed for the simultaneous determination of 8 adipate plasticizers in infant formula by isotope dilution-gas chromatography-mass spectrometry (GC-MS). With the infant formula sample completely dissolved in water, n-hexane was used as the extraction solvent. After ultrasonic extraction, qualitative and quantitative analysis were carried out by GC-MS in selected ion monitoring modes. The correlation coefficients (R²) of 8 adipate plasticizers were over 0.999, The limits of detection (LODs) were 0.08~0.12 mg/kg and the limits of quantification(LODs) were 0.2~0.4 mg/kg. The average recoveries of 8 adipate plasticizers in milk powder were ranged from 94.8% to 103.3%. In addition, the relative standard deviations (RSDs) were less than 8.1%. The method has advantage of simplicity, sensitivity and repeatability, which is suitable for testing of adipate plasticizers infant formula.