Human gamma-interferon expression in the mammary gland of transgenic mice |
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| Authors: | VN Dobrovolsky OV Lagutin TV Vinogradova IS Frolova VP Kuznetsov OA Larionov |
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| Affiliation: | Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow. |
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| Abstract: | Transgenic mice carrying a hybrid gene consisting of ovine beta-lactoglobulin gene sequences and human gamma-interferon (hIFN-g) cDNA were produced. hIFN-g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN-g in the milk was estimated as being ca. 1800 IU/ml. The hIFN-g ability to express in the mammary gland was found in the progeny of transgenic founder male. |
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