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Regeneration of Bombyx mori silk by electrospinning. Part 2. Process optimization and empirical modeling using response surface methodology |
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| Authors: | Sachiko Sukigara Jonathan Ayutsede Frank Ko |
| Affiliation: | a Faculty of Education and Human Sciences, Niigata University, 8050 Igarashi 2 no cho, Niigata city, Niigata 950-2181, Japan b School of Biomedical Engineering, Sciences and Health System, Drexel University, Philadelphia, PA 19104, USA c Fibrous Materials Research Laboratory, Department of Materials Science and Engineering, Drexel University, 31st and Market street, Philadelphia, PA 19104, USA |
| Abstract: | The response surface methodology was used to model and optimize the electrospinning parameters for the spinning of regenerated nanoscale silk fibers from domestic silkworm, Bombyx mori. Electric field and silk concentrations were chosen as variables to control fiber diameter at different spinning distances. Fiber diameter was correlated to these variables by using a second order polynomial function. The predicted fiber diameters were in agreement with the experimental results. Response surfaces were constructed to identify the processing window suitable for producing nanoscale fibers. |
| Keywords: | Electrospinning Silk Response surface methodology |
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