A novel agglomeration granulating system utilizing a centrifugal-fluidizing drive |
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| Authors: | Yoshiro Funakoshi Masaki Yamamoto Yoshihiko Matsumura Hiromu Komeda |
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| Affiliation: | Central Research Division, Takeda Chemical Industries, Ltd., Pharmaceutical Research Div., 17–85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532 Japan |
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| Abstract: | Necessary conditions were studied for the optimum operation of agglomeration granulation. The mechanisms that would realize these conditions were investigated by several experiments.On the basis of the results obtained, a novel granulating system involving a surface wetness control mechanism has been developed.The present paper describes the mixing and dispersing characteristics of the coating vessel, the detection method for wetness control, the particular spraying units, and the operating conditions thereof, together with the characteristics of this newly developed powder coating granulation system.This system has been shown to provide an easy and reproducible granulating technique even when products below 1 mm in size are required. |
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