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Eco-Sustainable Silk Fibroin/Pomegranate Peel Extract Film as an Innovative Green Material for Skin Repair
Authors:Marianna Barbalinardo  Marta Giannelli  Ludovica Forcini  Barbara Luppi  Anna Donnadio  Maria Luisa Navacchia  Giampiero Ruani  Giovanna Sotgiu  Annalisa Aluigi  Roberto Zamboni  Tamara Posati
Abstract:Skin disorders are widespread around the world, affecting people of all ages, and oxidative stress represents one of the main causes of alteration in the normal physiological parameters of skin cells. In this work, we combined a natural protein, fibroin, with antioxidant compounds extracted in water from pomegranate waste. We demonstrate the effective and facile fabrication of bioactive and eco-sustainable films of potential interest for skin repair. The blended films are visually transparent (around 90%); flexible; stable in physiological conditions and in the presence of trypsin for 12 days; able to release the bioactive compounds in a controlled manner; based on Fickian diffusion; and biocompatible towards the main skin cells, keratinocytes and fibroblasts. Furthermore, reactive oxygen species (ROS) production tests demonstrated the high capacity of our films to reduce the oxidative stress induced in cells, which is responsible for various skin diseases.
Keywords:silk fibroin   pomegranate waste   bioactive films   skin repair   circular economy
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