Optimized angle scanning method for array sample detection in surface plasmon resonance biosensor

An optimized angle scanning method is presented for array sample detection in a surface plasmon resonance biosensor. It provides a way to find the optimal rotation axis in the prism to resolve the drifting problem of the light incidence point on samples in the plane prism-coupling mode. The detection of array samples can be achieved by the translation of the prism along a particular direction. The validity of this method is theoretically analyzed and demonstrated by experiments.