Evaluation of in vitro stability of large unilamellar liposomes coated with a modified polysaccharide (O-palmitoylpullulan) |
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| Authors: | J N Moreira L M Almeida C F Geraldes M L Costa |
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| Affiliation: | (1) Laboratório de Tecnologia Farmacêutica da Faculdade de Farmácia, Rua do Norte, 3000 Coimbra, Portugal;(2) Laboratório de Bioquímica da Faculdade de Farmácia, Rua da Couraça dos Apóstolos, 3000 Coimbra, Portugal;(3) Departamento de Bioquímica, 3000 Coimbra, Portugal;(4) Centro de Neurociências da Universidade de Coimbra, 3000 Coimbra, Portugal |
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| Abstract: | Aiming at encapsulation of a hydrosoluble drug, large unilamellar liposomes (LUV) of egg phosphatidylcholine (PC) were coated with a natural polysaccharide derivative, O-palmitoylpullulan (OPP), and its in vitro stability evaluated using fluorescent probes. This coating (in OPP/PC weight ratio of 3) improved significantly the in vitro stability of LUV by decreasing both the permeability and fluidity of the liposomal membrane.This paper was accepted for publication after the 1995 Conference of the European Society of Biomaterials, Oporto, Portugal, 10–13 September. |
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