Processing and in vitro bioactivity of high-strength 45S5 glass-ceramic scaffolds for bone regeneration |
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| Affiliation: | 1. Department of Physics, Faculty of Science, Universiti Putra Malaysia, UPM Serdang, Selangor 43400, Malaysia;2. Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, UPM Serdang, Selangor 43400, Malaysia;3. Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia;1. Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Fraunhoferstr. 6, 07743 Jena, Germany;2. Department of Fiber Optics, Leibniz Institute of Photonic Technology, Albert-Einstein-Str. 9, 07745 Jena, Germany;1. School of Mechanical and Systems Engineering, Newcastle University, UK;2. School of Mechanical Engineering, University of Leeds, UK;3. Glass Technology Services Ltd, Sheffield, UK;4. Division of Trauma and Orthopaedic Surgery, University of Cambridge, UK;1. Université de Tunis El Manar, Faculty of Science, Chemistry Department, Materials Crystal Chemistry and Applied Thermodynamics Laboratory LR15SE01, Tunisia;2. Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Fraunhoferstr. 6, 07743 Jena, Germany;3. Institute of Biomaterials, Department Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstr. 6, 91058 Erlangen, Germany;1. Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Fraunhoferstr. 6, 07743 Jena, Germany;2. Chemical Physics and Materials Science, Institute of Physics, Augsburg University, Universitätsstr. 1, 86159 Augsburg, Germany;3. Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan |
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| Abstract: | In this paper, the compressive strength and in vitro bioactivity of sintered 45S5 bioactive glass scaffolds produced by powder technology and polymer foaming were investigated. The sintering temperature of scaffolds was 975 °C. The characterization of scaffolds before immersion in SBF was performed by scanning electron microscopy (SEM) and microtomography (μCT). The scaffolds were also tested for compression, and their density and porosity were measured. After immersion, the samples were observed through SEM and analyzed using EDS, X-ray diffraction (XRD), and infrared spectroscopy (FT-IR). Mass variation was also estimated. The glass-ceramic scaffolds showed a 61.44±3.13% interconnected porosity and an average compressive strength of 13.78±2.43 MPa. They also showed the formation of a hydroxyapatite layer after seven days of immersion in SBF, demonstrating that partial crystallization during sintering did not suppress their bioactivity. |
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| Keywords: | A Sintering B Porosity C Strength D Glass ceramics E Biomedical applications |
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