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| 医药中间体5-氨基-2,4,6-三碘异酞酸的合成研究 | |
| 引用本文： | 黄伯芬,王樱,程斌.医药中间体5-氨基-2,4,6-三碘异酞酸的合成研究[J].化工新型材料,2006,34(9):43-45. |
| 作者姓名： | 黄伯芬 王樱 程斌 |
| 作者单位： | 1. 南昌大学材料科学与工程学院,南昌,330047 2. 南昌工程学院,南昌,330029 3. 江西省科学院应用化学研究所,南昌,330029 |
| 摘 要： | 以5-硝基-异酞酸为原料,通过还原、碘取代反应,生成5-氨基-2,4,6-三碘异酞酸.重点对碘取代反应中反应介质、碘化剂的选取及碘化剂用量、反应温度、反应时间等参数及精制方法对反应得率影响进行了讨论,确定了最佳配方和工艺条件. |
| 关 键 词： | 医药中间体 5-氨基-2 4 6-三碘异酞酸 合成 |
| 修稿时间： | 2006年7月4日 |
Study on synthesis of 5-amino-2,4,6-triiodo-isophthalic acid as medicine intermediate |
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| Huang Bofen,Wang Ying,Cheng Bin.Study on synthesis of 5-amino-2,4,6-triiodo-isophthalic acid as medicine intermediate[J].New Chemical Materials,2006,34(9):43-45. | |
| Authors: | Huang Bofen Wang Ying Cheng Bin |
| Abstract: | 5-amino-2,4,6-triiodo-isophthalic acid was synthesized from 5-nitro-isophthalic acid by reduction and iodinate substitution reactions.The factors affecting the iodinate substitution reaction yield,such as reaction medium,choice of iodinate agent,chlorinated iodine dose,reaction temperature,reaction time and refining method of 5-amino-2,4,6-triiodo-isophthalic acid and etc.,were studied.The optimum reactant compostion and reaction conditions were obtained. |
| Keywords: | medicine intermediate 5-amino-2 4 6-triiodo-isophthalic acid synthesis |
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