Paramagnetic,NIR‐luminescent Nd3+‐ and Gd3+‐doped fluorapatite as contrast agent for multimodal biomedical imaging |
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| Authors: | Annemarie Tesch Robert Röder Maximilian Zapf Carsten Ronning Paul Warncke Dagmar Fischer Karl‐Heinz Herrmann Jürgen R. Reichenbach Frank A. Müller |
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| Affiliation: | 1. Otto Schott Institute of Materials Research (OSIM), Friedrich Schiller University Jena, Jena, Germany;2. Institute for Solid State Physics, Friedrich Schiller University Jena, Jena, Germany;3. Department of Pharmaceutical Technology and Biopharmacy, Friedrich Schiller University Jena, Jena, Germany;4. Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany |
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| Abstract: | ![]()
Combining near infrared (NIR) luminescence and magnetic resonance (MR) contrasts in a crystal host is highly desirable for contrast agents in biomedical imaging technology, as it will enable multimodal imaging processes. In the present work, biocompatible luminescent and paramagnetic fluorapatite (FAp) nanoparticles were prepared via doping with neodymium (Nd3+) and gadolinium (Gd3+), respectively. While Nd3+‐doped FAp (Nd:FAp) exhibits dopant concentration‐dependent photoluminescence (PL) in the NIR spectral region, Gd3+‐doped FAp (Gd:FAp) shows paramagnetic behavior and strong transverse relaxation effects resulting in MR contrastive properties. Remarkably, multimodal co‐doped FAp (Nd:Gd:FAp) nanoparticles combine both properties in 1 single crystal enabling luminescence as well as MR contrast. |
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| Keywords: | fluorapatite luminescence MRI rare‐earth elements |
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