液相色谱-高分辨质谱技术在兽药残留检测中的研究进展

随着社会经济的快速发展，人民生活水平不断提高，对动物源性食品的需求量也不断增加，动物源性食品中兽药残留问题也越来越受重视，对兽药残留的监督检验工作也提出了更高的要求。高分辨质谱具有极强的化合物检索能力，能够在无标准品的情况下实现多种兽药的非靶向筛查确证，很好地弥补了三重四极杆质谱检测宽泛性差、未知化合物筛查能力欠缺的缺点，是兽药残留风险监测和高通量筛查的重要技术手段。本文通过综述2018—2021年液相色谱-高分辨质谱技术在兽药残留检测领域中的应用情况，对高分辨质谱的优势和特点进行系统阐述。随着高分辨质谱仪的普及和检测技术的发展，高分辨质谱技术将可能作为常规检测方法被广泛应用于兽药残留检测领域。

Progress on Liquid Chromatography-High Resolution Mass Spectrometry in the Determination of Veterinary Drug Residues: A Review

With the rapid development of social economy and the continuous improvement of people’s living standards, the demand for foods of animal origin is also increasing. The problem of veterinary drug residues in foods of animal origin has attracted more and more attention. Meanwhile, higher requirements have been raised for the supervision and inspection of veterinary drug residues. High-resolution mass spectrometry (HRMS) is a powerful tool to retrieve compounds, which can enable the non-targeted screening and confirmation of a variety of veterinary drugs without the use of standards. HRMS is an important technical means for risk monitoring and high-throughput screening of veterinary drug residues, making up for the weaknesses of triple quadrupole mass spectrometry such as poor universality and no ability to screen unknown compounds. This review summarizes the application of liquid chromatography-high resolution mass spectrometry (LC-HRMS) in the field of veterinary drug residue detection from the year 2018 to 2021, and systematically demonstrates the advantages and characteristics of HRMS. With the popularization of HRMS and the development of detection technologies, HRMS will be widely used in the field of veterinary drug residue detection as a routine method.