超高压技术在蛋白质改性和活性肽制备中的应用研究进展

生物活性肽可以从植物、动物、海洋资源中获得，其具有多种生物活性，如抗高血压、抗氧化、抗血栓、降胆固醇、降血压、抗菌、免疫调节、细胞调节、结合矿物质等。提高蛋白质向多肽的转化率一直以来是多肽研究的难点之一，超高压技术是一种适合于规模化生产的新型非热加工物理技术，近年来被广泛地应用于蛋白质工程，超高压技术的应用改善了蛋白质的结构和功能特性，提高了生物活性肽提取、生产的效率。本文重点综述超高压技术在蛋白质改性和肽制备方面的应用，概述超高压制备生物活性肽的类型、来源和生物活性，以期为深入应用超高压技术辅助蛋白质改性和活性肽制备提供参考。

Progress in the Application of Ultra-High Pressure Technology in Protein Modification and Bioactive Peptide Preparation

Bioactive peptides can be obtained from plant, animal or marine sources. Bioactive peptides possess diverse biological activities such as antihypertension, antioxidant, antithrombosis, cholesterol-lowering, blood pressure-lowering, antibacterial, immune regulation, cell regulation, and mineral-binding properties. How to improve the conversion rate of proteins to peptides is always one of the difficulties in the research field of peptide. Ultra-high pressure technology is a novel non-thermal physical processing technology suitable for large-scale production, which has been widely used to the structural and functional characteristics of proteins, as well as the extraction and production efficiency of bioactive peptides. This review paper mainly focuses on the application of ultra-high pressure technology in protein modification and peptide preparation. The types, sources and biological activities of bioactive peptides prepared by ultra-high pressure technology are also summarized.