Multi-Slice DCE-MRI Data Using P760 Distinguishes Between Metastatic and Non-Metastatic Rodent Prostate Tumors |
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Authors: | Xiaobing Fan Milica Medved Sean Foxley Jonathan N River Marta Zamora Gregory S Karczmar Claire Corot Philippe Robert Philippe Bourrinet |
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Affiliation: | (1) Department of Radiology, University of Chicago, Chicago, IL 60637, USA;(2) Guerbet Laboratories, 95943 Roissy Charles De Gaulle, Cedex, France |
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Abstract: | An intermediate molecular weight contrast agent P760 was used to investigate the ability of multi-slice dynamic contrast-enhanced
MRI (DCE-MRI) to distinguish metastatic from non-metastatic rodent prostate tumors. Non-metastatic AT2.1 and metastatic AT3.1
prostate tumors originally derived from the Dunning prostate cancer model were implanted on the hind leg of Copenhagen rats.
Multi-sliced DCE-MRI data were acquired on a SIGNA 1.5 T scanner and analyzed using a recently developed empirical mathematical
model. The P760 multi-slice DCE-MRI data in combination with the empirical mathematical model successfully distinguished between
metastatic and non-metastatic rodent prostate tumors. Specifically, fitting the data with the empirical model showed that
metastatic tumors had significantly faster contrast media uptake (p<0.001) and slower washout rates (p<0.01) than non-metastatic tumors |
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Keywords: | Dynamic contrast enhanced MRI Prostate tumor P760 Rat |
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