| 桦褐孔菌多糖的抗肿瘤活性研究 |
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| 引用本文： | 陈义勇,顾小红,汤坚.桦褐孔菌多糖的抗肿瘤活性研究[J].食品与生物技术学报,2011,30(1):65-69. |
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| 作者姓名： | 陈义勇 顾小红 汤坚 |
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| 作者单位： | 1. 食品科学与技术国家重点实验室,江南大学,江苏,无锡,214122;常熟理工学院,生物与食品工程学院,江苏,常熟,215500
2. 食品科学与技术国家重点实验室,江南大学,江苏,无锡,214122 |
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| 摘 要： | 研究桦褐孔菌多糖对肿瘤细胞增殖的抑制和对荷瘤裸鼠的体内抑瘤作用。采用MTT法检测桦褐孔菌多糖对Jurkat和Daudi细胞增殖的影响,建立Jurkat荷瘤裸鼠模型,研究给药后对荷瘤裸鼠的抗肿瘤作用。表明桦褐孔菌多糖在体外具有直接杀死Jurkat和Daudi肿瘤细胞的作用,最高抑制率分别为62.29%和66.42%,具有良好的剂量-效应关系,同时具有显著的体内抗肿瘤活性,大小剂量对Jurkat荷瘤的抑制率分别为43.52%和57.48%,并且能显著提高裸鼠的脾脏指数,表明桦褐孔菌多糖具有显著的抗肿瘤活性和增强免疫功能。
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| 关 键 词： | 桦褐孔菌 多糖 抗肿瘤 |
Study on Anti-Tumor Activities of Polysaccharides from Inonotus obliquus |
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| CHEN Yi-yong,GU Xiao-hong and TANG Jian.Study on Anti-Tumor Activities of Polysaccharides from Inonotus obliquus[J].Journal of Food Science and Biotechnology,2011,30(1):65-69. |
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| Authors: | CHEN Yi-yong GU Xiao-hong and TANG Jian |
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| Affiliation: | CHEN Yi-yong1,2,GU Xiao-hong1,TANG Jian1(1.State Key Laboratory of Food Science & Technology,Jiangnan University,Wuxi 214122,China,2.School of Biology and Food Engineering,Changshu Institute of Technology,Changshu 215500,China) |
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| Abstract: | The research aimed to study the anti-tumor effect of polysaccharides from Inonotus obliquus(IOP)on tumor cell proliferation in vitro and on tumor-bearing nude mice in vivo.The effect of polysaccharides from Inonotus obliquus(IOP)on tumor Jurkat and Daudi cell proliferation was measured by MTT assay.The model of jurkat tumor-bearing nude was established.The anti-tumor effect of IOP on tumor-bearing nude mice in vivo was studied.The result showed that IOP could kill jurkat and daudi tumor cell directly in vit... |
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| Keywords: | Inonotus obliquus polysaccharide anti-tumor |
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