| 新型杀菌剂噻氟菌胺的合成研究 |
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| 引用本文： | 刘安昌,周青,沈乔.新型杀菌剂噻氟菌胺的合成研究[J].世界农药,2012,34(3):26-27. |
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| 作者姓名： | 刘安昌 周青 沈乔 |
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| 作者单位： | 武汉工程大学绿色化工过程省部共建教育部重点实验室湖北省新型反应器与绿色化学工艺重点实验室,武汉,430074 |
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| 摘 要： | 以三氟乙酰乙酸乙酯为原料,经氯气氯化得到2-氯-3-三氟乙酰乙酸乙酯,然后与硫代乙酰胺发生环化反应,反应产物水解得到2-甲基-4-三氟甲基-噻唑-5-甲酸.其经酰化后再以甲苯为溶剂,在碱性条件下与2,6-二溴4三氟甲氧基苯胺反应得到噻氟菌胺.总收率55.4％.
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| 关 键 词： | 噻氟菌胺 杀菌剂 合成 |
Study of Synthetic Process of Novel Fungicides Thifuzamide |
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| LIU An-chang
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ZHOU qing
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SHEN qiao.Study of Synthetic Process of Novel Fungicides Thifuzamide[J].World Pesticides,2012,34(3):26-27. |
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| Authors: | LIU An-chang ZHOU qing SHEN qiao |
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| Affiliation: | (Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology,Hubei,Wuhan,430074) |
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| Abstract: | 2-chloro-4,4,4-trifluoroacetoacetate was synthesized using trifluoro-acetoacetate as the primary material by bubbling chlorine,and then 2-methyl-4-(trifluoromethyl)-thiazole -5-carboxylic acid was prepared by the cyclization and hydrolysis reaction of 2-chloro -4,4,4-trifluoroacetoacetate and thioamide in acetonitrile solution.Then 2-methyl -4-(trifluoromethyl) thiazole -5-carboxylic acid reacted with thionyl chloride to give 2-methyl -4-(trifluoromethyl)thiazole -5-carboxylic acid chloride,and the compound was reacted with 2,6-dibromo-4-trifluoromethoxy aniline in toluene to give the thifuzamide in the yield of above 55.4%. |
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| Keywords: | thifuzamide fungicides synthesis |
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