Asymmetric synthesis of 4'-alpha-alkylcarbovir derivatives |
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Authors: | K Kato H Suzuki H Tanaka T Miyasaka |
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Affiliation: | School of Pharmaceutical Science, Toho University, Chiba, Japan. |
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Abstract: | Asymmetric synthesis of 4'-alpha-alkylcarbovir derivatives 3 were achieved based on Sakai's asymmetric alkylation of beta-keto esters. The key carbocyclic intermediate 12 was synthesized from 6 via an eleven-step sequence. Coupling of 12 with 2-amino-6-chloropurine followed by desilylation and subsequent hydrolysis gave the target compounds 3 in moderate yields. |
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