氮硫掺杂石墨烯量子点荧光探针测定葡萄酒中铜离子的含量

铜是哺乳动物所需营养中的微量元素，每天摄入1.5 - 2.0 mg铜是必不可少的。但过量的摄入铜对人体会产生毒性，而且测定血清和尿液中的铜水平对于某些疾病的早期诊断是非常重要的，因此建立铜的定量分析方法尤为重要。本实验基于Cu²⁺对氮硫掺杂石墨烯量子点的较强的荧光猝灭作用，建立了一种快速、高灵敏检测Cu²⁺的方法，结果表明检测范围具有可调性，最低检出限为2.708 nmol/L。并通过变温实验和热力学计算探究了其猝灭机理为静态猝灭过程。

Research on the Interaction between Cupric Ions and Nitrogen Sulphur Doped Graphene Quantum Dots

Copper is a trace element in mammalian nutrition, and it is essential to daily intake of 1.5-2.0 mg of copper. However, excessive intake of copper can cause toxicity to the human body, so it is very important to quantitative analysis copper levels of serum and urine in early diagnosis of certain diseases. In this paper, based on the strong fluorescence quenching effect of Cu²⁺ on nitrogen-sulfur-doped graphene quantum dots, a rapid, highly sensitive and reliable method was established, the limit of determination is 2.708 nmol/L. Variable temperature experiments and thermodynamic calculations were explored to discuss the mechanism of fluorescence quenching, results show that the quenching process is static quenching process.