| RP-HPLC法丙交酯纯度的定量测定 |
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| 引用本文： | 冯立栋,高战团,边新超,白骅,陈志明,陈学思.RP-HPLC法丙交酯纯度的定量测定[J].高分子材料科学与工程,2009(11). |
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| 作者姓名： | 冯立栋 高战团 边新超 白骅 陈志明 陈学思 |
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| 作者单位： | 浙江海正生物材料股份有限公司;中国科学院长春应用化学研究所;高分子物理与化学国家重点实验室; |
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| 基金项目： | 浙江省科技计划项目(2004C13020); 国家科技部攻关计划项目(2005BA314C); 国家发展改革委员会高新技术产业化项目(发改办高技2006(2352号)) |
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| 摘 要： | 建立了高效液相色谱(HPLC)测定丙交酯纯度的方法。解决了分析过程中丙交酯水解不稳定的问题。在HPLC分析过程中,无水的有机流动相不能实现丙交酯与其它杂质的分离,有机溶剂和水的混合溶液作流动相能有效改善丙交酯与其它杂质的分离效果。通过对实验条件的摸索,并对丙交酯水解动力学进行研究,发现丙交酯在选定的色谱条件下,在流动相中的水解反应具有准一级反应动力学的特征,由此可对丙交酯进行定量分析。实验表明,相对标准偏差RSD<1.0%,方法切实可行。
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| 关 键 词： | 丙交酯 定量 高效液相色谱 动力学 聚乳酸 |
Analytical Method of L-Lactide Purity Determination by RP-HPLC |
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| FENG Li-dong,GAO Zhan-tuan,BIAN Xin-chao, BAI Hua,CHEN Zhi-ming,CHEN Xue-si.Analytical Method of L-Lactide Purity Determination by RP-HPLC[J].Polymer Materials Science & Engineering,2009(11). |
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| Authors: | FENG Li-dong GAO Zhan-tuan BIAN Xin-chao BAI Hua CHEN Zhi-ming CHEN Xue-si |
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| Affiliation: | FENG Li-dong1,2,GAO Zhan-tuan1,BIAN Xin-chao1,2 BAI Hua1,CHEN Zhi-ming1,CHEN Xue-si1,2 (1.Zhejiang Hisun Biomaterials Co.,LTD,Taizhou 31800,China,2.State Key laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China) |
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| Abstract: | A new analytical method has been developed for determination of L-lactide purity by reverse phase HPLC(RP-HPLC).The unstable problem of the L-lactide hydrolysis was solved in the analytical process.L-lactide could not be separated from its impure mixture in anhydrous organic mobile phases,and the mobile phases of water and organic mixing solutions were used to realize the separation effectively.The L-lactide hydrolysis kinetics was proved as pseudo-first-order reaction in the mobile phase of the given RP-HP... |
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| Keywords: | L-lactide quantification RP-HPLC kinetics poly(L-lactic acid) |
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