| 抗癌中药苦杏仁中金属元素含量测定研究 |
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| 引用本文： | 罗志冬,杨欣欣,包永睿,等. 抗癌中药苦杏仁中金属元素含量测定研究[J]. 辽宁化工, 2014, 0(2): 146-148 |
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| 作者姓名： | 罗志冬 杨欣欣 包永睿 等 |
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| 作者单位： | [1]东北制药集团股份有限公司,辽宁沈阳110027 [2]辽宁中医药大学药学院,辽宁大连116600 [3]辽宁省组分中药工程技术研究中心,辽宁大连116600 [4]中国医科大学,辽宁沈阳110001 |
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| 基金项目： | 国家“重大新药创制”科技重大专项,项目号：2010ZX09401-304-105C. |
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| 摘 要： | 对苦杏仁的化学成分、药理作用等进行了归纳总结,采用电感耦合等离子体质谱法,找出苦杏仁中与抗肿瘤功效相关的金属元素,初步探究其抗癌机制。实验结果表明,苦杏仁中含有较高含量的Mg、K、Ca、Fe、Zn等金属元素,通过文献调研,初步确定苦杏仁的抗癌机制与Mg、K、Ca、Fe、Zn等金属元素有关。
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| 关 键 词： | 苦杏仁 金属元素 ICP-MS |
Study on Determination of Metal Elements Content of Anticancer Traditional Chinese Medicine Bitter Almond |
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| Affiliation: | LUO Zhi-dong, YANG Xin-xin, BAO Yong-rui, MENG Xian-sheng, ZHU Rui-qin ( 1. Northeast Pharmaceutical Group Co.,Ltd., Liaoning Shenyang 110027, China; 2. Liaoning University of Traditional Chinese Medicine, Liaoning Dalian 116600, China;3. Liaoning Province Engineering Research Center of Chinese Medicine Ingredients, Liaoning Dalian 116600, China;4.China Medical University, Liaoning Shenyang 110001,China) |
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| Abstract: | Chemical composition and pharmacological effects of almond were summarized. Metal elements with antitumous effect in the almond were found out by using inductively coupled plasma mass spectrometry, and their anticancer mechanisms investigated. The results show that, bitter almond contains higher levels of Mg, K, Ca, Fe, Zn and other metal elements, they have antitumous effect. |
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| Keywords: | bitter almond metal elements ICP-MS |
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